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Rsad2 radical S-adenosyl methionine domain containing 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 65190, updated on 5-Jun-2021

Summary

Official Symbol
Rsad2provided by RGD
Official Full Name
radical S-adenosyl methionine domain containing 2provided by RGD
Primary source
RGD:620495
See related
Ensembl:ENSRNOG00000007539
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Vig1; Best5
Summary
protein involved in bone formation [RGD, Feb 2006]
Expression
Biased expression in Spleen (RPKM 1011.4), Heart (RPKM 128.5) and 2 other tissues See more
Orthologs
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Genomic context

See Rsad2 in Genome Data Viewer
Location:
6q16
Exon count:
7
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (43046514..43059737, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (45655947..45669083, complement)

Chromosome 6 - NC_051341.1Genomic Context describing neighboring genes Neighboring gene similar to D-3-phosphoglycerate dehydrogenase (3-PGDH) Neighboring gene ring finger protein 144A Neighboring gene cytidine/uridine monophosphate kinase 2 Neighboring gene uncharacterized LOC108351213

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 4 iron, 4 sulfur cluster binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables 4 iron, 4 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
 
enables 4 iron, 4 sulfur cluster binding ISO
Inferred from Sequence Orthology
more info
 
enables 4 iron, 4 sulfur cluster binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables lyase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables molecular_function ND
No biological Data available
more info
 
enables protein self-association IEA
Inferred from Electronic Annotation
more info
 
enables protein self-association ISO
Inferred from Sequence Orthology
more info
 
enables protein self-association ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in CD4-positive, alpha-beta T cell activation ISO
Inferred from Sequence Orthology
more info
 
involved_in CD4-positive, alpha-beta T cell activation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in CD4-positive, alpha-beta T cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in CD4-positive, alpha-beta T cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in CD4-positive, alpha-beta T cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in defense response to virus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in defense response to virus IEA
Inferred from Electronic Annotation
more info
 
involved_in defense response to virus ISO
Inferred from Sequence Orthology
more info
 
involved_in defense response to virus ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of protein secretion IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of protein secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of viral genome replication IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of viral genome replication ISO
Inferred from Sequence Orthology
more info
 
involved_in ossification IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of T-helper 2 cell cytokine production IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of T-helper 2 cell cytokine production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of T-helper 2 cell cytokine production ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of toll-like receptor 7 signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of toll-like receptor 7 signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of toll-like receptor 7 signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of toll-like receptor 9 signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of toll-like receptor 9 signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of toll-like receptor 9 signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of ossification IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to virus ISO
Inferred from Sequence Orthology
more info
 
involved_in response to virus ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in fibrillar center IEA
Inferred from Electronic Annotation
more info
 
located_in fibrillar center ISO
Inferred from Sequence Orthology
more info
 
located_in lipid droplet IEA
Inferred from Electronic Annotation
more info
 
located_in lipid droplet ISO
Inferred from Sequence Orthology
more info
 
located_in lipid droplet ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial outer membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
radical S-adenosyl methionine domain-containing protein 2
Names
bone-expressed sequence tag 5 protein
viperin
virus inhibitory protein, endoplasmic reticulum-associated, interferon-inducible

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_138881.2NP_620236.1  radical S-adenosyl methionine domain-containing protein 2

    See identical proteins and their annotated locations for NP_620236.1

    Status: PROVISIONAL

    Source sequence(s)
    JACYVU010000164
    UniProtKB/Swiss-Prot
    O70600
    Related
    ENSRNOP00000010092.7, ENSRNOT00000010092.7
    Conserved Domains (2) summary
    cd01335
    Location:77254
    Radical_SAM; Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster. ...
    TIGR04278
    Location:11360
    viperin; antiviral radical SAM protein viperin

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051341.1 Reference mRatBN7.2 Primary Assembly

    Range
    43046514..43059737 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039112917.1XP_038968845.1  radical S-adenosyl methionine domain-containing protein 2 isoform X1

    Conserved Domains (1) summary
    TIGR04278
    Location:13308
    viperin; antiviral radical SAM protein viperin
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