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Stk3 serine/threonine kinase 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 65189, updated on 18-Apr-2019

Summary

Official Symbol
Stk3provided by RGD
Official Full Name
serine/threonine kinase 3provided by RGD
Primary source
RGD:68412
See related
Ensembl:ENSRNOG00000011278
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
MST2
Summary
has serine/threonine kinase activity; catalyzes the phosphorylation of thyroid transcription factor-1 [RGD, Feb 2006]
Expression
Biased expression in Kidney (RPKM 64.2), Adrenal (RPKM 61.7) and 9 other tissues See more
Orthologs

Genomic context

See Stk3 in Genome Data Viewer
Location:
7q22
Exon count:
14
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (73617926..73883896, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 7 NC_005106.3 (73793705..74055204, complement)

Chromosome 7 - NC_005106.4Genomic Context describing neighboring genes Neighboring gene NIPA-like domain containing 2 Neighboring gene uncharacterized LOC102553465 Neighboring gene potassium voltage-gated channel, modifier subfamily S, member 2 Neighboring gene hypothetical LOC100361374 Neighboring gene odd-skipped related transciption factor 2

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from BioSystems

  • Hippo signaling, organism-specific biosystem (from KEGG)
    Hippo signaling, organism-specific biosystemFunctional set; Cellular processes; Cell signaling
  • Hippo signaling, conserved biosystem (from KEGG)
    Hippo signaling, conserved biosystemFunctional set; Cellular processes; Cell signaling
  • Hippo signaling pathway, organism-specific biosystem (from KEGG)
    Hippo signaling pathway, organism-specific biosystemHippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor S...
  • Hippo signaling pathway, conserved biosystem (from KEGG)
    Hippo signaling pathway, conserved biosystemHippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor S...
  • Hippo signaling pathway -multiple species, organism-specific biosystem (from KEGG)
    Hippo signaling pathway -multiple species, organism-specific biosystemHippo signaling pathways control diverse aspects of cell proliferation, survival, and morphogenesis in eukaryotes. The core organization of these networks is conserved over a billion years of evoluti...
  • Hippo signaling pathway -multiple species, conserved biosystem (from KEGG)
    Hippo signaling pathway -multiple species, conserved biosystemHippo signaling pathways control diverse aspects of cell proliferation, survival, and morphogenesis in eukaryotes. The core organization of these networks is conserved over a billion years of evoluti...
  • MAPK signaling pathway, organism-specific biosystem (from KEGG)
    MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
  • MAPK signaling pathway, organism-specific biosystem (from WikiPathways)
    MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
  • MAPK signaling pathway, conserved biosystem (from KEGG)
    MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Signaling by Hippo, organism-specific biosystem (from REACTOME)
    Signaling by Hippo, organism-specific biosystemcomputationally inferred pathway (not manually curated)

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
ATP binding ISO
Inferred from Sequence Orthology
more info
PubMed 
identical protein binding IEA
Inferred from Electronic Annotation
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
PubMed 
magnesium ion binding IEA
Inferred from Electronic Annotation
more info
 
magnesium ion binding ISO
Inferred from Sequence Orthology
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein kinase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
protein kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
activation of protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
cell differentiation involved in embryonic placenta development IEA
Inferred from Electronic Annotation
more info
 
cell differentiation involved in embryonic placenta development ISO
Inferred from Sequence Orthology
more info
PubMed 
central nervous system development IEA
Inferred from Electronic Annotation
more info
 
central nervous system development ISO
Inferred from Sequence Orthology
more info
PubMed 
endocardium development IEA
Inferred from Electronic Annotation
more info
 
endocardium development ISO
Inferred from Sequence Orthology
more info
PubMed 
hepatocyte apoptotic process IEA
Inferred from Electronic Annotation
more info
 
hepatocyte apoptotic process ISO
Inferred from Sequence Orthology
more info
PubMed 
hippo signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
hippo signaling IEA
Inferred from Electronic Annotation
more info
 
hippo signaling ISO
Inferred from Sequence Orthology
more info
PubMed 
hippo signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of canonical Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
negative regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of organ growth IEA
Inferred from Electronic Annotation
more info
 
negative regulation of organ growth ISO
Inferred from Sequence Orthology
more info
PubMed 
neural tube formation IEA
Inferred from Electronic Annotation
more info
 
neural tube formation ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of JNK cascade IEA
Inferred from Electronic Annotation
more info
 
positive regulation of JNK cascade ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors IEA
Inferred from Electronic Annotation
more info
 
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of fat cell differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of fat cell differentiation ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of protein binding IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein binding ISO
Inferred from Sequence Orthology
more info
PubMed 
positive regulation of protein kinase B signaling IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein kinase B signaling ISO
Inferred from Sequence Orthology
more info
PubMed 
primitive hemopoiesis IEA
Inferred from Electronic Annotation
more info
 
primitive hemopoiesis ISO
Inferred from Sequence Orthology
more info
PubMed 
protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
protein phosphorylation ISO
Inferred from Sequence Orthology
more info
PubMed 
protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
protein stabilization IEA
Inferred from Electronic Annotation
more info
 
protein stabilization ISO
Inferred from Sequence Orthology
more info
PubMed 
regulation of cell differentiation involved in embryonic placenta development IEA
Inferred from Electronic Annotation
more info
 
regulation of cell differentiation involved in embryonic placenta development ISO
Inferred from Sequence Orthology
more info
PubMed 
signal transduction by protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
stress-activated protein kinase signaling cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
PubMed 
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
protein-containing complex IEA
Inferred from Electronic Annotation
more info
 
protein-containing complex ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
serine/threonine-protein kinase 3
Names
MST-2
STE20-like kinase MST2
mammalian STE20-like protein kinase 2
serine/threonine kinase 3 (STE20 homolog, yeast)
NP_113923.1
XP_008763680.1
XP_008763681.1
XP_008763682.1
XP_008763684.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031735.1NP_113923.1  serine/threonine-protein kinase 3

    See identical proteins and their annotated locations for NP_113923.1

    Status: PROVISIONAL

    Source sequence(s)
    AJ001529
    UniProtKB/Swiss-Prot
    O54748
    Related
    ENSRNOP00000062778.1, ENSRNOT00000065722.3
    Conserved Domains (3) summary
    cd06612
    Location:23278
    STKc_MST1_2; Catalytic domain of the Serine/Threonine Kinases, Mammalian STe20-like protein kinase 1 and 2
    smart00220
    Location:27278
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam11629
    Location:437484
    Mst1_SARAH; C terminal SARAH domain of Mst1

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005106.4 Reference Rnor_6.0 Primary Assembly

    Range
    73617926..73883896 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008765462.2XP_008763684.1  serine/threonine-protein kinase 3 isoform X4

    Conserved Domains (3) summary
    smart00220
    Location:27167
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam11629
    Location:326373
    Mst1_SARAH; C terminal SARAH domain of Mst1
    cl21453
    Location:23167
    PKc_like; Protein Kinases, catalytic domain
  2. XM_008765459.2XP_008763681.1  serine/threonine-protein kinase 3 isoform X2

    Conserved Domains (2) summary
    cd06612
    Location:23278
    STKc_MST1_2; Catalytic domain of the Serine/Threonine Kinases, Mammalian STe20-like protein kinase 1 and 2
    smart00220
    Location:27278
    S_TKc; Serine/Threonine protein kinases, catalytic domain
  3. XM_008765458.2XP_008763680.1  serine/threonine-protein kinase 3 isoform X1

    Conserved Domains (2) summary
    cd06612
    Location:23278
    STKc_MST1_2; Catalytic domain of the Serine/Threonine Kinases, Mammalian STe20-like protein kinase 1 and 2
    smart00220
    Location:27278
    S_TKc; Serine/Threonine protein kinases, catalytic domain
  4. XM_008765460.2XP_008763682.1  serine/threonine-protein kinase 3 isoform X3

    Conserved Domains (2) summary
    cd06612
    Location:1205
    STKc_MST1_2; Catalytic domain of the Serine/Threonine Kinases, Mammalian STe20-like protein kinase 1 and 2
    smart00220
    Location:1205
    S_TKc; Serine/Threonine protein kinases, catalytic domain

Alternate Rn_Celera

Genomic

  1. AC_000075.1 Alternate Rn_Celera

    Range
    63152608..63416831 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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