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Htra1 HtrA serine peptidase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 65164, updated on 8-Apr-2026
Official Symbol
Htra1provided by RGD
Official Full Name
HtrA serine peptidase 1provided by RGD
Primary source
RGD:69235
See related
Ensembl:ENSRNOG00000020533 AllianceGenome:RGD:69235
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Prss11
Summary
Predicted to enable identical protein binding activity; molecular function activator activity; and serine-type endopeptidase activity. Involved in dentinogenesis; negative regulation of defense response to virus; and positive regulation of epithelial cell proliferation. Located in collagen-containing extracellular matrix. Human ortholog(s) of this gene implicated in CADASIL (multiple); gastrointestinal system cancer (multiple); hypertension; lung adenocarcinoma; and macular degeneration (multiple). Orthologous to human HTRA1 (HtrA serine peptidase 1). [provided by Alliance of Genome Resources, Apr 2025]
Expression
Biased expression in Adrenal (RPKM 413.0), Heart (RPKM 246.1) and 9 other tissues See more
Orthologs
all
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Try the new Transcripts and proteins table
See Htra1 in Genome Data Viewer
Location:
1q41
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (194928069..194977619)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (185497815..185547380)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (201499067..201548508)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene BTB domain containing 16 Neighboring gene pleckstrin homology domain containing A1 Neighboring gene uncharacterized LOC134485181 Neighboring gene deleted in malignant brain tumors 1 Neighboring gene similar to human chromosome 10 open reading frame 120

Go to nucleotide: Graphics FASTA GenBank

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Related articles in PubMed

  1. HtrA1, a potential predictor of response to cisplatin-based combination chemotherapy in gastric cancer. Catalano V, et al. Histopathology, 2011 Apr. PMID 21447133
  2. Identifying subtypes of patients with neovascular age-related macular degeneration by genotypic and cardiovascular risk characteristics. Feehan M, et al. BMC Med Genet, 2011 Jun 17. PMID 21682878, Free PMC Article
  3. Quantitative determination of high-temperature requirement protein A1 and its possible associated molecules during induced reparative dentin formation. Li X, et al. J Endod, 2012 Jun. PMID 22595117
  4. Association of genetic polymorphisms and age-related macular degeneration in Chinese population. Tian J, et al. Invest Ophthalmol Vis Sci, 2012 Jun 28. PMID 22618592
  5. [Interaction of susceptibility genes in patients with exudative age-related macular degeneration]. Liang X, et al. Zhonghua Yan Ke Za Zhi, 2012 Mar. PMID 22800422

See all (47) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Porphyromonas gingivalis-mediated disruption in spiral artery remodeling is associated with altered uterine NK cell populations and dysregulated IL-18 and Htra1.
    Title: Porphyromonas gingivalis-mediated disruption in spiral artery remodeling is associated with altered uterine NK cell populations and dysregulated IL-18 and Htra1.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC93339

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables molecular function activator activity ISO
Inferred from Sequence Orthology
more info
  
enables serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables serine-type peptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables serine-type peptidase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within chorionic trophoblast cell differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of BMP signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of defense response to virus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within placenta development ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of epithelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in programmed cell death IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis ISO
Inferred from Sequence Orthology
more info
  
involved_in proteolysis ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular matrix IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
Preferred Names
serine protease HTRA1
Names
high-temperature requirement A serine peptidase 1
protease serine 11
protease, serine, 11 (Igf binding)
serine protease 11
NP_113909.1

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031721.1 → NP_113909.1  serine protease HTRA1 precursor

    See identical proteins and their annotated locations for NP_113909.1

    Status: PROVISIONAL

    Source sequence(s)
    AF179370
    UniProtKB/Swiss-Prot
    Q9QZK5
    UniProtKB/TrEMBL
    A0A8L2QHG9
    Related
    ENSRNOP00000027860.3, ENSRNOT00000027860.6
    Conserved Domains (5) summary
    smart00121
    Location:37 → 111
    IB; Insulin growth factor-binding protein homologues
    smart00280
    Location:115 → 155
    KAZAL; Kazal type serine protease inhibitors
    COG0265
    Location:154 → 480
    DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
    cd00987
    Location:382 → 473
    PDZ_serine_protease; PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind ...
    pfam13365
    Location:204 → 342
    Trypsin_2; Trypsin-like peptidase domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    194928069..194977619
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9QZK5.1 GenPept UniProtKB/Swiss-Prot:Q9QZK5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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