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SLC2A3 solute carrier family 2 member 3 [ Homo sapiens (human) ]

Gene ID: 6515, updated on 1-Jun-2020

Summary

Official Symbol
SLC2A3provided by HGNC
Official Full Name
solute carrier family 2 member 3provided by HGNC
Primary source
HGNC:HGNC:11007
See related
Ensembl:ENSG00000059804 MIM:138170
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GLUT3
Expression
Biased expression in bone marrow (RPKM 183.0), placenta (RPKM 54.5) and 11 other tissues See more
Orthologs

Genomic context

See SLC2A3 in Genome Data Viewer
Location:
12p13.31
Exon count:
10
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (7919230..7936187, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (8071824..8088895, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene solute carrier family 2 member 14 Neighboring gene myosin light chain 9 pseudogene Neighboring gene Nanog homeobox pseudogene 1 Neighboring gene CRISPRi-validated cis-regulatory element chr12.441 Neighboring gene CRISPRi-validated cis-regulatory element chr12.444

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of solute carrier family 2 (facilitated glucose transporter), member 3 (SLC2A3) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ90380

Gene Ontology Provided by GOA

Function Evidence Code Pubs
glucose binding IDA
Inferred from Direct Assay
more info
PubMed 
glucose transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
L-ascorbic acid metabolic process TAS
Traceable Author Statement
more info
 
carbohydrate metabolic process NAS
Non-traceable Author Statement
more info
PubMed 
glucose transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
glucose transmembrane transport TAS
Traceable Author Statement
more info
 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cell projection IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome HDA PubMed 
ficolin-1-rich granule membrane TAS
Traceable Author Statement
more info
 
integral component of membrane IDA
Inferred from Direct Assay
more info
PubMed 
integral component of plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
perikaryon IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
secretory granule membrane TAS
Traceable Author Statement
more info
 
specific granule membrane TAS
Traceable Author Statement
more info
 
tertiary granule membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
solute carrier family 2, facilitated glucose transporter member 3
Names
GLUT-3
glucose transporter type 3, brain
solute carrier family 2 (facilitated glucose transporter), member 3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006931.3NP_008862.1  solute carrier family 2, facilitated glucose transporter member 3

    See identical proteins and their annotated locations for NP_008862.1

    Status: VALIDATED

    Source sequence(s)
    AC007536
    Consensus CDS
    CCDS8586.1
    UniProtKB/Swiss-Prot
    P11169
    Related
    ENSP00000075120.7, ENST00000075120.12
    Conserved Domains (1) summary
    pfam00083
    Location:15465
    Sugar_tr; Sugar (and other) transporter

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    7919230..7936187 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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