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WNK1 WNK lysine deficient protein kinase 1 [ Homo sapiens (human) ]

Gene ID: 65125, updated on 27-Nov-2024

Summary

Official Symbol
WNK1provided by HGNC
Official Full Name
WNK lysine deficient protein kinase 1provided by HGNC
Primary source
HGNC:HGNC:14540
See related
Ensembl:ENSG00000060237 MIM:605232; AllianceGenome:HGNC:14540
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KDP; PSK; p65; HSN2; HSAN2; PRKWNK1; PPP1R167
Summary
This gene encodes a member of the WNK subfamily of serine/threonine protein kinases. The encoded protein may be a key regulator of blood pressure by controlling the transport of sodium and chloride ions. Mutations in this gene have been associated with pseudohypoaldosteronism type II and hereditary sensory neuropathy type II. Alternatively spliced transcript variants encoding different isoforms have been described but the full-length nature of all of them has yet to be determined.[provided by RefSeq, May 2010]
Expression
Ubiquitous expression in kidney (RPKM 30.2), fat (RPKM 24.6) and 25 other tissues See more
Orthologs
NEW
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Try the new Transcript table

Genomic context

See WNK1 in Genome Data Viewer
Location:
12p13.33
Exon count:
31
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (752579..911452)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (748443..907208)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (861745..1020618)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4103 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5779 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5780 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5781 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4104 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4105 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr12:754531-755730 Neighboring gene Sharpr-MPRA regulatory region 6322 Neighboring gene ninjurin 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:775809-776308 Neighboring gene NINJ2 antisense RNA 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:780043-780251 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5782 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5783 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5784 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5785 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5786 Neighboring gene uncharacterized LOC101929432 Neighboring gene long intergenic non-protein coding RNA 2455 Neighboring gene CRISPRi-validated cis-regulatory element chr12.51 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5787 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5788 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5789 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5790 Neighboring gene H3K27ac hESC enhancers GRCh37_chr12:861758-862476 and GRCh37_chr12:862477-863195 Neighboring gene RNA, U4atac small nuclear 16, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5791 Neighboring gene OCT4-H3K27ac hESC enhancer GRCh37_chr12:917646-918146 Neighboring gene OCT4-H3K27ac hESC enhancer GRCh37_chr12:918147-918647 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5792 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr12:1023012-1024211 Neighboring gene uncharacterized LOC124902855 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:1058032-1058690 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:1058691-1059349 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:1067429-1067930 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:1067931-1068430 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr12:1083331-1083878 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:1092618-1092819 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:1099220-1099782 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4110 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:1100344-1100905 Neighboring gene Sharpr-MPRA regulatory region 6010 Neighboring gene RAD52 homolog, DNA repair protein Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:1115216-1115716 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:1115717-1116217 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:1181067-1181567 Neighboring gene ELKS/RAB6-interacting/CAST family member 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5795 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr12:1224566-1225765 Neighboring gene uncharacterized LOC124902857

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk.
EBI GWAS Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of WNK lysine deficient protein kinase 1 (WNK1) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed
Knockdown of WNK lysine deficient protein kinase 1 (WNK1) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • KIAA0344, MGC163339, MGC163341

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 3-phosphoinositide-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables AMP-activated protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables Rho-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables eukaryotic translation initiation factor 2alpha kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H2AS121 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H2AT120 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H2AXS139 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H2BS14 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H2BS36 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3S10 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3S28 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3S57 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3T11 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3T3 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3T45 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H3T6 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables histone H4S1 kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables molecular condensate scaffold activity IDA
Inferred from Direct Assay
more info
PubMed 
enables phosphatase binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activator activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
PubMed 
enables ribosomal protein S6 kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in DNA damage response IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in T cell receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in cell volume homeostasis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular hyperosmotic response IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to chemokine IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in chemokine (C-C motif) ligand 21 signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
 
involved_in heart development IEA
Inferred from Electronic Annotation
more info
 
involved_in intracellular chloride ion homeostasis IEA
Inferred from Electronic Annotation
more info
 
involved_in intracellular signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in intracellular signal transduction TAS
Traceable Author Statement
more info
PubMed 
involved_in lymphocyte migration into lymph node ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in membraneless organelle assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in monoatomic cation homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in monoatomic ion transport ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within negative regulation of GTPase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of autophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cell-cell adhesion mediated by integrin IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of heterotypic cell-cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of leukocyte cell-cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of pancreatic juice secretion IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of protein localization to plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of protein ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of sodium ion transport ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in neuron development NAS
Non-traceable Author Statement
more info
PubMed 
involved_in peptidyl-serine phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
acts_upstream_of_or_within peptidyl-threonine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of peptidyl-threonine phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in peptidyl-threonine phosphorylation TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of T cell chemotaxis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of mitotic cytokinesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of systemic arterial blood pressure IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of termination of RNA polymerase II transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in potassium ion homeostasis IEA
Inferred from Electronic Annotation
more info
 
involved_in protein insertion into ER membrane by stop-transfer membrane-anchor sequence IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of mRNA export from nucleus IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of regulation of monoatomic cation transmembrane transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of sodium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of sodium ion transport ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in sodium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in intracellular membraneless organelle IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in mitotic spindle IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein-containing complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
serine/threonine-protein kinase WNK1
Names
erythrocyte 65 kDa protein
prostate-derived sterile 20-like kinase
protein kinase with no lysine 1
protein phosphatase 1, regulatory subunit 167
serine/threonine-protein kinase WNK1 1
serine/threonine-protein kinase WNK1 2
NP_001171914.1
NP_055638.2
NP_061852.3
NP_998820.3
XP_006719066.1
XP_011519299.1
XP_011519300.1
XP_011519301.1
XP_011519302.1
XP_011519303.1
XP_011519304.1
XP_011519305.1
XP_011519308.1
XP_011519309.1
XP_011519310.1
XP_011519311.1
XP_016875323.1
XP_016875324.1
XP_016875325.1
XP_016875326.1
XP_016875327.1
XP_047285330.1
XP_047285331.1
XP_047285332.1
XP_047285333.1
XP_047285334.1
XP_047285335.1
XP_047285336.1
XP_047285337.1
XP_047285338.1
XP_047285339.1
XP_047285340.1
XP_047285341.1
XP_047285342.1
XP_047285343.1
XP_047285344.1
XP_047285345.1
XP_047285346.1
XP_047285347.1
XP_047285348.1
XP_047285349.1
XP_047285350.1
XP_047285351.1
XP_047285352.1
XP_047285353.1
XP_047285354.1
XP_047285355.1
XP_047285356.1
XP_047285357.1
XP_047285358.1
XP_047285359.1
XP_054228909.1
XP_054228910.1
XP_054228911.1
XP_054228912.1
XP_054228913.1
XP_054228914.1
XP_054228915.1
XP_054228916.1
XP_054228917.1
XP_054228918.1
XP_054228919.1
XP_054228920.1
XP_054228921.1
XP_054228922.1
XP_054228923.1
XP_054228924.1
XP_054228925.1
XP_054228926.1
XP_054228927.1
XP_054228928.1
XP_054228929.1
XP_054228930.1
XP_054228931.1
XP_054228932.1
XP_054228933.1
XP_054228934.1
XP_054228935.1
XP_054228936.1
XP_054228937.1
XP_054228938.1
XP_054228939.1
XP_054228940.1
XP_054228941.1
XP_054228942.1
XP_054228943.1
XP_054228944.1
XP_054228945.1
XP_054228946.1
XP_054228947.1
XP_054228948.1
XP_054228949.1
XP_054228950.1
XP_054228951.1
XP_054228952.1
XP_054228953.1
XP_054228954.1
XP_054228955.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_007984.3 RefSeqGene

    Range
    4521..163394
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_247

mRNA and Protein(s)

  1. NM_001184985.2NP_001171914.1  serine/threonine-protein kinase WNK1 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) has multiple differences in the coding region but maintains the reading frame compared to variant 1. This variant represents the exon combination of the dorsal root ganglia and sciatic nerve variant described in Figure 2F of PubMed ID 18521183. This variant encodes isoform 4, which is longer than isoform 1.
    Source sequence(s)
    AC004765, AC004803
    UniProtKB/Swiss-Prot
    Q9H4A3
    Related
    ENSP00000444465.1, ENST00000537687.5
    Conserved Domains (3) summary
    smart00220
    Location:226479
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14030
    Location:195483
    STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
    pfam12202
    Location:500537
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
  2. NM_014823.3NP_055638.2  serine/threonine-protein kinase WNK1 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses two alternative splice sites and lacks two exons in the coding region compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1.
    Source sequence(s)
    AB002342, AC004765, AC004803, AI074334, AJ296290, BC141881, BX644268, CD629562, DA720959
    Consensus CDS
    CCDS53731.1
    UniProtKB/TrEMBL
    F5GWT4
    Related
    ENSP00000441972.1, ENST00000535572.5
    Conserved Domains (3) summary
    smart00220
    Location:226479
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14030
    Location:195483
    STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
    pfam12202
    Location:500537
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
  3. NM_018979.4NP_061852.3  serine/threonine-protein kinase WNK1 isoform 1

    See identical proteins and their annotated locations for NP_061852.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the most common isoform (1), as indicated in PubMed ID 18521183.
    Source sequence(s)
    AB002342, AC004765, AC004803, AI074334, AJ296290, BC141881, BX644268, CD629562, DA720959
    Consensus CDS
    CCDS8506.1
    UniProtKB/Swiss-Prot
    A1L4B0, C5HTZ5, C5HTZ6, C5HTZ7, H6WZW3, O15052, P54963, Q4VBX9, Q6IFS5, Q86WL5, Q8N673, Q96CZ6, Q9H4A3, Q9P1S9
    Related
    ENSP00000313059.6, ENST00000315939.11
    Conserved Domains (3) summary
    smart00220
    Location:226479
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14030
    Location:195483
    STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
    pfam12202
    Location:500537
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
  4. NM_213655.5NP_998820.3  serine/threonine-protein kinase WNK1 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has multiple differences in the coding region but maintains the reading frame compared to variant 1. This variant represents the exon combination of the brain and spinal cord variant described in Figure 2F of PubMed ID 18521183. This variant encodes isoform 3, which is longer than isoform 1.
    Source sequence(s)
    AC004765, AC004803
    Consensus CDS
    CCDS73419.1
    UniProtKB/Swiss-Prot
    Q9H4A3
    Related
    ENSP00000341292.5, ENST00000340908.9
    Conserved Domains (3) summary
    smart00220
    Location:226479
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14030
    Location:195483
    STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
    pfam12202
    Location:500537
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    752579..911452
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011520997.4XP_011519299.1  serine/threonine-protein kinase WNK1 isoform X1

    Related
    ENSP00000433548.3, ENST00000530271.6
    Conserved Domains (3) summary
    smart00220
    Location:226479
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14030
    Location:195483
    STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
    pfam12202
    Location:500537
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
  2. XM_011521000.3XP_011519302.1  serine/threonine-protein kinase WNK1 isoform X4

    Conserved Domains (3) summary
    smart00220
    Location:226479
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14030
    Location:195483
    STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
    pfam12202
    Location:500537
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
  3. XM_011520999.3XP_011519301.1  serine/threonine-protein kinase WNK1 isoform X3

    Conserved Domains (3) summary
    smart00220
    Location:226479
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14030
    Location:195483
    STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
    pfam12202
    Location:500537
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
  4. XM_047429374.1XP_047285330.1  serine/threonine-protein kinase WNK1 isoform X5

  5. XM_011521001.3XP_011519303.1  serine/threonine-protein kinase WNK1 isoform X6

    Conserved Domains (3) summary
    smart00220
    Location:226479
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14030
    Location:195483
    STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
    pfam12202
    Location:500537
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
  6. XM_047429375.1XP_047285331.1  serine/threonine-protein kinase WNK1 isoform X7

  7. XM_047429376.1XP_047285332.1  serine/threonine-protein kinase WNK1 isoform X9

  8. XM_011521003.3XP_011519305.1  serine/threonine-protein kinase WNK1 isoform X10

    Conserved Domains (3) summary
    smart00220
    Location:226479
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14030
    Location:195483
    STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
    pfam12202
    Location:500537
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
  9. XM_011520998.3XP_011519300.1  serine/threonine-protein kinase WNK1 isoform X2

    Conserved Domains (3) summary
    smart00220
    Location:226479
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14030
    Location:195483
    STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
    pfam12202
    Location:500537
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
  10. XM_011521002.3XP_011519304.1  serine/threonine-protein kinase WNK1 isoform X8

    Conserved Domains (3) summary
    smart00220
    Location:226479
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14030
    Location:195483
    STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
    pfam12202
    Location:500537
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
  11. XM_047429377.1XP_047285333.1  serine/threonine-protein kinase WNK1 isoform X12

  12. XM_047429380.1XP_047285336.1  serine/threonine-protein kinase WNK1 isoform X17

  13. XM_047429383.1XP_047285339.1  serine/threonine-protein kinase WNK1 isoform X20

  14. XM_047429388.1XP_047285344.1  serine/threonine-protein kinase WNK1 isoform X25

  15. XM_047429393.1XP_047285349.1  serine/threonine-protein kinase WNK1 isoform X33

  16. XM_047429389.1XP_047285345.1  serine/threonine-protein kinase WNK1 isoform X27

  17. XM_017019837.2XP_016875326.1  serine/threonine-protein kinase WNK1 isoform X34

    Conserved Domains (3) summary
    smart00220
    Location:226479
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14030
    Location:195483
    STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
    pfam12202
    Location:500537
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
  18. XM_047429400.1XP_047285356.1  serine/threonine-protein kinase WNK1 isoform X44

  19. XM_047429395.1XP_047285351.1  serine/threonine-protein kinase WNK1 isoform X37

  20. XM_006719003.3XP_006719066.1  serine/threonine-protein kinase WNK1 isoform X11

    Conserved Domains (2) summary
    PHA03247
    Location:15721866
    PHA03247; large tegument protein UL36; Provisional
    cd14030
    Location:195483
    STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
  21. XM_047429378.1XP_047285334.1  serine/threonine-protein kinase WNK1 isoform X13

  22. XM_047429382.1XP_047285338.1  serine/threonine-protein kinase WNK1 isoform X19

  23. XM_047429384.1XP_047285340.1  serine/threonine-protein kinase WNK1 isoform X21

  24. XM_017019834.2XP_016875323.1  serine/threonine-protein kinase WNK1 isoform X26

  25. XM_047429390.1XP_047285346.1  serine/threonine-protein kinase WNK1 isoform X28

  26. XM_017019838.2XP_016875327.1  serine/threonine-protein kinase WNK1 isoform X36

  27. XM_047429401.1XP_047285357.1  serine/threonine-protein kinase WNK1 isoform X45

  28. XM_047429402.1XP_047285358.1  serine/threonine-protein kinase WNK1 isoform X46

  29. XM_011521006.3XP_011519308.1  serine/threonine-protein kinase WNK1 isoform X14

    Conserved Domains (3) summary
    smart00220
    Location:226479
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14030
    Location:195483
    STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
    pfam12202
    Location:500537
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
  30. XM_047429381.1XP_047285337.1  serine/threonine-protein kinase WNK1 isoform X18

  31. XM_047429379.1XP_047285335.1  serine/threonine-protein kinase WNK1 isoform X16

  32. XM_047429385.1XP_047285341.1  serine/threonine-protein kinase WNK1 isoform X22

  33. XM_017019835.2XP_016875324.1  serine/threonine-protein kinase WNK1 isoform X29

  34. XM_047429394.1XP_047285350.1  serine/threonine-protein kinase WNK1 isoform X35

  35. XM_047429391.1XP_047285347.1  serine/threonine-protein kinase WNK1 isoform X31

  36. XM_047429397.1XP_047285353.1  serine/threonine-protein kinase WNK1 isoform X39

  37. XM_011521008.3XP_011519310.1  serine/threonine-protein kinase WNK1 isoform X40

    Conserved Domains (3) summary
    smart00220
    Location:226479
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14030
    Location:195483
    STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
    pfam12202
    Location:500537
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
  38. XM_047429398.1XP_047285354.1  serine/threonine-protein kinase WNK1 isoform X42

  39. XM_011521007.3XP_011519309.1  serine/threonine-protein kinase WNK1 isoform X15

    Conserved Domains (3) summary
    smart00220
    Location:226479
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14030
    Location:195483
    STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
    pfam12202
    Location:500537
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
  40. XM_047429386.1XP_047285342.1  serine/threonine-protein kinase WNK1 isoform X23

  41. XM_047429387.1XP_047285343.1  serine/threonine-protein kinase WNK1 isoform X24

  42. XM_017019836.2XP_016875325.1  serine/threonine-protein kinase WNK1 isoform X30

  43. XM_047429396.1XP_047285352.1  serine/threonine-protein kinase WNK1 isoform X38

  44. XM_047429392.1XP_047285348.1  serine/threonine-protein kinase WNK1 isoform X32

  45. XM_011521009.3XP_011519311.1  serine/threonine-protein kinase WNK1 isoform X41

    Conserved Domains (3) summary
    smart00220
    Location:226479
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14030
    Location:195483
    STKc_WNK1; Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1
    pfam12202
    Location:500537
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
  46. XM_047429399.1XP_047285355.1  serine/threonine-protein kinase WNK1 isoform X43

  47. XM_047429403.1XP_047285359.1  serine/threonine-protein kinase WNK1 isoform X47

    Related
    ENSP00000502415.1, ENST00000675631.1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    748443..907208
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054372934.1XP_054228909.1  serine/threonine-protein kinase WNK1 isoform X1

  2. XM_054372937.1XP_054228912.1  serine/threonine-protein kinase WNK1 isoform X4

  3. XM_054372936.1XP_054228911.1  serine/threonine-protein kinase WNK1 isoform X3

  4. XM_054372938.1XP_054228913.1  serine/threonine-protein kinase WNK1 isoform X5

  5. XM_054372939.1XP_054228914.1  serine/threonine-protein kinase WNK1 isoform X6

  6. XM_054372940.1XP_054228915.1  serine/threonine-protein kinase WNK1 isoform X7

  7. XM_054372942.1XP_054228917.1  serine/threonine-protein kinase WNK1 isoform X9

  8. XM_054372943.1XP_054228918.1  serine/threonine-protein kinase WNK1 isoform X10

  9. XM_054372935.1XP_054228910.1  serine/threonine-protein kinase WNK1 isoform X2

  10. XM_054372941.1XP_054228916.1  serine/threonine-protein kinase WNK1 isoform X8

  11. XM_054372945.1XP_054228920.1  serine/threonine-protein kinase WNK1 isoform X12

  12. XM_054372950.1XP_054228925.1  serine/threonine-protein kinase WNK1 isoform X17

  13. XM_054372953.1XP_054228928.1  serine/threonine-protein kinase WNK1 isoform X20

  14. XM_054372958.1XP_054228933.1  serine/threonine-protein kinase WNK1 isoform X25

  15. XM_054372966.1XP_054228941.1  serine/threonine-protein kinase WNK1 isoform X33

  16. XM_054372960.1XP_054228935.1  serine/threonine-protein kinase WNK1 isoform X27

  17. XM_054372967.1XP_054228942.1  serine/threonine-protein kinase WNK1 isoform X34

  18. XM_054372977.1XP_054228952.1  serine/threonine-protein kinase WNK1 isoform X44

  19. XM_054372970.1XP_054228945.1  serine/threonine-protein kinase WNK1 isoform X37

  20. XM_054372944.1XP_054228919.1  serine/threonine-protein kinase WNK1 isoform X11

  21. XM_054372946.1XP_054228921.1  serine/threonine-protein kinase WNK1 isoform X13

  22. XM_054372952.1XP_054228927.1  serine/threonine-protein kinase WNK1 isoform X19

  23. XM_054372954.1XP_054228929.1  serine/threonine-protein kinase WNK1 isoform X21

  24. XM_054372959.1XP_054228934.1  serine/threonine-protein kinase WNK1 isoform X26

  25. XM_054372961.1XP_054228936.1  serine/threonine-protein kinase WNK1 isoform X28

  26. XM_054372969.1XP_054228944.1  serine/threonine-protein kinase WNK1 isoform X36

  27. XM_054372978.1XP_054228953.1  serine/threonine-protein kinase WNK1 isoform X45

  28. XM_054372979.1XP_054228954.1  serine/threonine-protein kinase WNK1 isoform X46

  29. XM_054372947.1XP_054228922.1  serine/threonine-protein kinase WNK1 isoform X14

  30. XM_054372951.1XP_054228926.1  serine/threonine-protein kinase WNK1 isoform X18

  31. XM_054372949.1XP_054228924.1  serine/threonine-protein kinase WNK1 isoform X16

  32. XM_054372955.1XP_054228930.1  serine/threonine-protein kinase WNK1 isoform X22

  33. XM_054372962.1XP_054228937.1  serine/threonine-protein kinase WNK1 isoform X29

  34. XM_054372968.1XP_054228943.1  serine/threonine-protein kinase WNK1 isoform X35

  35. XM_054372964.1XP_054228939.1  serine/threonine-protein kinase WNK1 isoform X31

  36. XM_054372972.1XP_054228947.1  serine/threonine-protein kinase WNK1 isoform X39

  37. XM_054372973.1XP_054228948.1  serine/threonine-protein kinase WNK1 isoform X40

  38. XM_054372975.1XP_054228950.1  serine/threonine-protein kinase WNK1 isoform X42

  39. XM_054372948.1XP_054228923.1  serine/threonine-protein kinase WNK1 isoform X15

  40. XM_054372956.1XP_054228931.1  serine/threonine-protein kinase WNK1 isoform X23

  41. XM_054372957.1XP_054228932.1  serine/threonine-protein kinase WNK1 isoform X24

  42. XM_054372963.1XP_054228938.1  serine/threonine-protein kinase WNK1 isoform X30

  43. XM_054372971.1XP_054228946.1  serine/threonine-protein kinase WNK1 isoform X38

  44. XM_054372965.1XP_054228940.1  serine/threonine-protein kinase WNK1 isoform X32

  45. XM_054372974.1XP_054228949.1  serine/threonine-protein kinase WNK1 isoform X41

  46. XM_054372976.1XP_054228951.1  serine/threonine-protein kinase WNK1 isoform X43

  47. XM_054372980.1XP_054228955.1  serine/threonine-protein kinase WNK1 isoform X47