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INTS3 integrator complex subunit 3 [ Homo sapiens (human) ]

Gene ID: 65123, updated on 1-Aug-2020

Summary

Official Symbol
INTS3provided by HGNC
Official Full Name
integrator complex subunit 3provided by HGNC
Primary source
HGNC:HGNC:26153
See related
Ensembl:ENSG00000143624 MIM:611347
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
INT3; SOSSA; SOSS-A; C1orf60; C1orf193
Summary
The protein encoded by this gene can form a complex with human single-strand DNA binding proteins 1 or 2 (hSSB1 and hSSB2) and other proteins to mediate genome stability and the DNA damage response. The encoded protein is also part of a multiprotein complex that interacts with the C-terminal domain of RNA polymerase II large subunit to help regulate processing of U1 and U2 small nuclear RNAs. [provided by RefSeq, May 2016]
Expression
Ubiquitous expression in testis (RPKM 20.6), ovary (RPKM 17.9) and 25 other tissues See more
Orthologs

Genomic context

See INTS3 in Genome Data Viewer
Location:
1q21.3
Exon count:
30
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (153728050..153774808)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (153700526..153746555)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene natriuretic peptide receptor 1 Neighboring gene microRNA 8083 Neighboring gene gem nuclear organelle associated protein 2 pseudogene 1 Neighboring gene RNA, 7SL, cytoplasmic 372, pseudogene Neighboring gene solute carrier family 27 member 3 Neighboring gene immunoglobulin superfamily DCC subclass member 3 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ21919, FLJ44849, DKFZp686E1950, DKFZp781I1253, DKFZp686O20115

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
DNA repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to DNA damage stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitotic cell cycle checkpoint IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to ionizing radiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
snRNA processing IDA
Inferred from Direct Assay
more info
PubMed 
snRNA transcription by RNA polymerase II TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
SOSS complex IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
integrator complex IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
integrator complex subunit 3
Names
SOSS complex subunit A
sensor of single-strand DNA complex subunit A
sensor of ssDNA subunit A

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_050682.1 RefSeqGene

    Range
    5018..51759
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001324475.2NP_001311404.1  integrator complex subunit 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AK290025, AL513523, BX110564, CR749376
    Consensus CDS
    CCDS1052.1
    UniProtKB/Swiss-Prot
    Q68E01
    Related
    ENSP00000404290.2, ENST00000435409.6
    Conserved Domains (1) summary
    pfam10189
    Location:270494
    Ints3; Integrator complex subunit 3
  2. NM_023015.5NP_075391.3  integrator complex subunit 3

    See identical proteins and their annotated locations for NP_075391.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AL513523
    Consensus CDS
    CCDS1052.1
    UniProtKB/Swiss-Prot
    Q68E01
    Related
    ENSP00000318641.2, ENST00000318967.7
    Conserved Domains (1) summary
    pfam10189
    Location:270494
    Ints3; Integrator complex subunit 3

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    153728050..153774808
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NW_003315905.1 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    44751..91509
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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