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INTS3 integrator complex subunit 3 [ Homo sapiens (human) ]

Gene ID: 65123, updated on 5-Jan-2025

Summary

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Official Symbol
INTS3provided by HGNC
Official Full Name
integrator complex subunit 3provided by HGNC
Primary source
HGNC:HGNC:26153
See related
Ensembl:ENSG00000143624 MIM:611347; AllianceGenome:HGNC:26153
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
INT3; SOSSA; SOSS-A; C1orf60; C1orf193
Summary
The protein encoded by this gene can form a complex with human single-strand DNA binding proteins 1 or 2 (hSSB1 and hSSB2) and other proteins to mediate genome stability and the DNA damage response. The encoded protein is also part of a multiprotein complex that interacts with the C-terminal domain of RNA polymerase II large subunit to help regulate processing of U1 and U2 small nuclear RNAs. [provided by RefSeq, May 2016]
Expression
Ubiquitous expression in testis (RPKM 20.6), ovary (RPKM 17.9) and 25 other tissues See more
Orthologs
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Genomic context

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See INTS3 in Genome Data Viewer
Location:
1q21.3
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (153728050..153774808)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (152865319..152912062)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (153700526..153747284)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene natriuretic peptide receptor 1 Neighboring gene microRNA 8083 Neighboring gene gem nuclear organelle associated protein 2 pseudogene 1 Neighboring gene RNA, 7SL, cytoplasmic 372, pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr1:153700292-153700463 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:153706223-153706722 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:153717251-153717990 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:153717991-153718730 Neighboring gene small nucleolar RNA U13 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:153748284-153748950 Neighboring gene solute carrier family 27 member 3 Neighboring gene uncharacterized LOC124904424 Neighboring gene uncharacterized LOC124904426

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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Related articles in PubMed

  1. The Integrator complex controls the termination of transcription at diverse classes of gene targets. Skaar JR, et al. Cell Res, 2015 Mar. PMID 25675981, Free PMC Article
  2. Structural basis for multifunctional roles of human Ints3 C-terminal domain. Li J, et al. J Biol Chem, 2021 Jan-Jun. PMID 33434574, Free PMC Article
  3. Subnuclear domain proteins in cancer cells support the functions of RUNX2 in the DNA damage response. Yang S, et al. J Cell Sci, 2015 Feb 15. PMID 25609707, Free PMC Article
  4. Biochemical characterization of INTS3 and C9ORF80, two subunits of hNABP1/2 heterotrimeric complex in nucleic acid binding. Vidhyasagar V, et al. Biochem J, 2018 Jan 2. PMID 29150435, Free PMC Article
  5. INTS3 controls the hSSB1-mediated DNA damage response. Skaar JR, et al. J Cell Biol, 2009 Oct 5. PMID 19786574, Free PMC Article

See all (85) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. INTS3, but not C9ORF80, affects the nucleic acid-binding ability of hNABP1 and hNABP2, indicating that INTS3 might regulate hNABP1/hNABP2 biological function, while the role of C9ORF80 remains unknown.
    Title: Biochemical characterization of INTS3 and C9ORF80, two subunits of hNABP1/2 heterotrimeric complex in nucleic acid binding.
  2. In response to the DNA damage response, INTS3-hSSB1-INTS6 complex relocates to the DNA damage sites.
    Title: A core hSSB1-INTS complex participates in the DNA damage response.
  3. INT3 plays a key role in the DNA damage response
    Title: Integrator3, a partner of single-stranded DNA-binding protein 1, participates in the DNA damage response.
  4. INTS3 controls the hSSB1-mediated DNA damage response.
    Title: INTS3 controls the hSSB1-mediated DNA damage response.
  5. INTS3 is part of an ssDNA-binding heterotrimeric complex, SOSS which is involved in the maintenance of genome stability.
    Title: SOSS complexes participate in the maintenance of genomic stability.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ21919, FLJ44849, DKFZp686E1950, DKFZp781I1253, DKFZp686O20115

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA damage response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in DNA repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in double-strand break repair via homologous recombination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in mitotic G2/M transition checkpoint IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in mitotic G2/M transition checkpoint IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription elongation by RNA polymerase II NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in response to ionizing radiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in snRNA processing IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in snRNA processing NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of SOSS complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of SOSS complex IPI
Inferred from Physical Interaction
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
part_of integrator complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of integrator complex NAS
Non-traceable Author Statement
more info
 PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus NAS
Non-traceable Author Statement
more info
 PubMed 
located_in site of double-strand break IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
integrator complex subunit 3
Names
SOSS complex subunit A
sensor of single-strand DNA complex subunit A
sensor of ssDNA subunit A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_050682.2 RefSeqGene

    Range
    5002..51760
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001324475.2 → NP_001311404.1  integrator complex subunit 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AK290025, AL513523, BX110564, CR749376
    Consensus CDS
    CCDS1052.1
    UniProtKB/Swiss-Prot
    A8K1W0, B4DQC8, B4E3U9, D3DV57, Q4G0E5, Q5VUQ5, Q5VUQ6, Q5VUR0, Q5VUR1, Q68DJ1, Q68E01, Q69YR5, Q6AI57, Q6DKG7, Q6MZQ4, Q6MZZ9, Q8NC46, Q8TB23, Q9H6S9
    Related
    ENSP00000404290.2, ENST00000435409.6
    Conserved Domains (1) summary
    pfam10189
    Location:270 → 494
    Ints3; Integrator complex subunit 3

  2. NM_023015.5 → NP_075391.3  integrator complex subunit 3

    See identical proteins and their annotated locations for NP_075391.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AL513523
    Consensus CDS
    CCDS1052.1
    UniProtKB/Swiss-Prot
    A8K1W0, B4DQC8, B4E3U9, D3DV57, Q4G0E5, Q5VUQ5, Q5VUQ6, Q5VUR0, Q5VUR1, Q68DJ1, Q68E01, Q69YR5, Q6AI57, Q6DKG7, Q6MZQ4, Q6MZZ9, Q8NC46, Q8TB23, Q9H6S9
    Related
    ENSP00000318641.2, ENST00000318967.7
    Conserved Domains (1) summary
    pfam10189
    Location:270 → 494
    Ints3; Integrator complex subunit 3

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    153728050..153774808
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NW_003315905.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    44751..91509
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    152865319..152912062
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q68E01.1 GenPept UniProtKB/Swiss-Prot:Q68E01

Gene LinkOut

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