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MARCKSL1 MARCKS like 1 [ Homo sapiens (human) ]

Gene ID: 65108, updated on 4-Oct-2020

Summary

Official Symbol
MARCKSL1provided by HGNC
Official Full Name
MARCKS like 1provided by HGNC
Primary source
HGNC:HGNC:7142
See related
Ensembl:ENSG00000175130 MIM:602940
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
F52; MLP; MRP; MLP1; MACMARCKS
Summary
This gene encodes a member of the myristoylated alanine-rich C-kinase substrate (MARCKS) family. Members of this family play a role in cytoskeletal regulation, protein kinase C signaling and calmodulin signaling. The encoded protein affects the formation of adherens junction. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene are located on the long arm of chromosomes 6 and 10. [provided by RefSeq, Jun 2012]
Expression
Broad expression in ovary (RPKM 132.8), brain (RPKM 127.5) and 24 other tissues See more
Orthologs

Genomic context

See MARCKSL1 in Genome Data Viewer
Location:
1p35.1
Exon count:
2
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (32333839..32336233, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (32799430..32801840, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene LCK proto-oncogene, Src family tyrosine kinase Neighboring gene histone deacetylase 1 Neighboring gene uncharacterized LOC105378629 Neighboring gene testis specific serine kinase 3 Neighboring gene family with sequence similarity 229 member A

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
actin binding IEA
Inferred from Electronic Annotation
more info
 
actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calmodulin binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
central nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome HDA PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
MARCKS-related protein
Names
MARCKS-like protein 1
mac-MARCKS
macrophage myristoylated alanine-rich C kinase substrate

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_023009.7NP_075385.1  MARCKS-related protein

    See identical proteins and their annotated locations for NP_075385.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and is protein coding.
    Source sequence(s)
    AI879076, BC007904, N70661
    Consensus CDS
    CCDS361.1
    UniProtKB/Swiss-Prot
    P49006
    Related
    ENSP00000362638.4, ENST00000329421.8
    Conserved Domains (1) summary
    pfam02063
    Location:5195
    MARCKS; MARCKS family

RNA

  1. NR_052852.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site compared to variant 1. This variant is represented as non-coding because it lacks an in-frame coding region compared to variant 1.
    Source sequence(s)
    AL109945, BC007904, DT218825

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    32333839..32336233 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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