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Rtn4r reticulon 4 receptor [ Mus musculus (house mouse) ]

Gene ID: 65079, updated on 8-Dec-2018

Summary

Official Symbol
Rtn4rprovided by MGI
Official Full Name
reticulon 4 receptorprovided by MGI
Primary source
MGI:MGI:2136886
See related
Ensembl:ENSMUSG00000043811
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NgR; NgR1; NOGOR
Expression
Broad expression in cortex adult (RPKM 55.4), frontal lobe adult (RPKM 33.2) and 15 other tissues See more
Orthologs

Genomic context

See Rtn4r in Genome Data Viewer
Location:
16; 16 A3
Exon count:
2
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 16 NC_000082.6 (18127706..18152408)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 16 NC_000082.5 (18127799..18152501)

Chromosome 16 - NC_000082.6Genomic Context describing neighboring genes Neighboring gene DiGeorge syndrome critical region gene 6 Neighboring gene proline dehydrogenase Neighboring gene microRNA 6366 Neighboring gene predicted gene, 34679

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

  • PluriNetWork, organism-specific biosystem (from WikiPathways)
    PluriNetWork, organism-specific biosystemThe aim of the PluriNetWork is to give an overview of specific mechanisms associated with pluripotency in mouse. Each node represents a gene and its corresponding protein product. As stated, we inten...
  • Spinal Cord Injury, organism-specific biosystem (from WikiPathways)
    Spinal Cord Injury, organism-specific biosystemThis pathway provides an overview of cell types, therapeutic targets, drugs, new proposed targets and pathways implicated in spinal cord injury. Spinal cord injury is a complex multi-step process tha...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
chondroitin sulfate binding IDA
Inferred from Direct Assay
more info
PubMed 
ganglioside GM1 binding ISO
Inferred from Sequence Orthology
more info
 
ganglioside GT1b binding ISO
Inferred from Sequence Orthology
more info
 
heparin binding IDA
Inferred from Direct Assay
more info
PubMed 
neuregulin receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
signaling receptor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
axonogenesis IDA
Inferred from Direct Assay
more info
PubMed 
cell surface receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
corpus callosum development IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of axon extension IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of axon regeneration IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of neuron projection development IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
 
neuronal signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of Rho protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
anchored component of external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
anchored component of membrane IEA
Inferred from Electronic Annotation
more info
 
axonal growth cone IDA
Inferred from Direct Assay
more info
PubMed 
cell projection IEA
Inferred from Electronic Annotation
more info
 
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
cell surface ISO
Inferred from Sequence Orthology
more info
 
dendritic shaft IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
growth cone IDA
Inferred from Direct Assay
more info
PubMed 
integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
membrane IEA
Inferred from Electronic Annotation
more info
 
membrane raft ISO
Inferred from Sequence Orthology
more info
 
neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
presynapse ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
reticulon-4 receptor
Names
nogo66 receptor-1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022982.3NP_075358.1  reticulon-4 receptor precursor

    See identical proteins and their annotated locations for NP_075358.1

    Status: VALIDATED

    Source sequence(s)
    AC087064, AC118542
    Consensus CDS
    CCDS37279.1
    UniProtKB/Swiss-Prot
    Q99PI8
    Related
    ENSMUSP00000062924.5, ENSMUST00000059589.5
    Conserved Domains (4) summary
    cd00116
    Location:90166
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:6082
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:156195
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:131190
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000082.6 Reference GRCm38.p4 C57BL/6J

    Range
    18127706..18152408
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCm38.p4 129S1/SvImJ

Genomic

  1. NT_187007.1 Reference GRCm38.p4 129S1/SvImJ

    Range
    385195..410057
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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