Format

Send to:

Choose Destination

Rtn4r reticulon 4 receptor [ Mus musculus (house mouse) ]

Gene ID: 65079, updated on 5-Jan-2022

Summary

Official Symbol
Rtn4rprovided by MGI
Official Full Name
reticulon 4 receptorprovided by MGI
Primary source
MGI:MGI:2136886
See related
Ensembl:ENSMUSG00000043811
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NgR; NgR1; NOGOR
Summary
Enables chondroitin sulfate binding activity; heparin binding activity; and neuregulin receptor activity. Involved in several processes, including corpus callosum development; negative regulation of neuron projection development; and neuronal signal transduction. Acts upstream of or within axonogenesis. Located in several cellular components, including axonal growth cone; dendritic shaft; and neuronal cell body. Is integral component of plasma membrane. Is expressed in several structures, including cardiovascular system; forelimb bud; intestine; male reproductive gland or organ; and nervous system. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human RTN4R (reticulon 4 receptor). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Broad expression in cortex adult (RPKM 55.4), frontal lobe adult (RPKM 33.2) and 15 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Rtn4r in Genome Data Viewer
Location:
16; 16 A3
Exon count:
2
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (17945506..17970272)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (18127642..18152408)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 16 NC_000082.5 (18127799..18152501)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene DiGeorge syndrome critical region gene 6 Neighboring gene proline dehydrogenase Neighboring gene predicted gene, 52241 Neighboring gene predicted gene, 53937 Neighboring gene microRNA 6366

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables Roundabout binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables chondroitin sulfate binding IDA
Inferred from Direct Assay
more info
PubMed 
enables ganglioside GM1 binding ISO
Inferred from Sequence Orthology
more info
 
enables ganglioside GT1b binding ISO
Inferred from Sequence Orthology
more info
 
enables heparin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables heparin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables neuregulin receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in anchored component of external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in anchored component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in axonal growth cone IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in dendritic shaft IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in growth cone IDA
Inferred from Direct Assay
more info
PubMed 
located_in integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
 
located_in neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
reticulon-4 receptor
Names
nogo66 receptor-1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022982.3NP_075358.1  reticulon-4 receptor precursor

    See identical proteins and their annotated locations for NP_075358.1

    Status: VALIDATED

    Source sequence(s)
    AC087064, AC118542
    Consensus CDS
    CCDS37279.1
    UniProtKB/Swiss-Prot
    Q99PI8
    Related
    ENSMUSP00000062924.6, ENSMUST00000059589.6
    Conserved Domains (4) summary
    cd00116
    Location:90166
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:6082
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:156195
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:131190
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    17945506..17970272
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center