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CDK15 cyclin dependent kinase 15 [ Homo sapiens (human) ]

Gene ID: 65061, updated on 25-Nov-2021

Summary

Official Symbol
CDK15provided by HGNC
Official Full Name
cyclin dependent kinase 15provided by HGNC
Primary source
HGNC:HGNC:14434
See related
Ensembl:ENSG00000138395 MIM:616147
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PFTK2; ALS2CR7; PFTAIRE2
Expression
Biased expression in ovary (RPKM 1.2), gall bladder (RPKM 0.5) and 13 other tissues See more
Orthologs
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Genomic context

See CDK15 in Genome Data Viewer
Location:
2q33.1
Exon count:
23
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (201790324..201895550)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (202671152..202760273)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 651, pseudogene Neighboring gene MAGUK p55 scaffold protein 4 Neighboring gene alsin Rho guanine nucleotide exchange factor ALS2 Neighboring gene ribosomal protein S2 pseudogene 16 Neighboring gene UBE2V1 pseudogene 11 Neighboring gene RNA, U6 small nuclear 440, pseudogene Neighboring gene Sharpr-MPRA regulatory region 8332

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables cyclin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables cyclin-dependent protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine/threonine/tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of transcription involved in G1/S transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
cyclin-dependent kinase 15
Names
PFTAIRE protein kinase 2
amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 7
amyotrophic lateral sclerosis 2 chromosomal region candidate gene 7 protein
cell division protein kinase 15
serine/threonine protein kinase
serine/threonine-protein kinase ALS2CR7
serine/threonine-protein kinase PFTAIRE-2
NP_001248364.1
NP_001248365.1
NP_001353315.1
NP_631897.1
XP_005246839.1
XP_011509952.1
XP_011509954.1
XP_011509956.1
XP_011509957.1
XP_011509958.1
XP_011509959.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001261435.1NP_001248364.1  cyclin-dependent kinase 15 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest protein (isoform 1).
    Source sequence(s)
    AC007242, AC007358, BX647394, DA050598
    Consensus CDS
    CCDS58747.1
    UniProtKB/Swiss-Prot
    Q96Q40
    Related
    ENSP00000406472.2, ENST00000450471.6
    Conserved Domains (2) summary
    PLN00009
    Location:103390
    PLN00009; cyclin-dependent kinase A; Provisional
    cd07870
    Location:102387
    STKc_PFTAIRE2; Catalytic domain of the Serine/Threonine Kinase, PFTAIRE-2 kinase
  2. NM_001261436.1NP_001248365.1  cyclin-dependent kinase 15 isoform 2

    See identical proteins and their annotated locations for NP_001248365.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' coding region and UTR compared to variant 1. The resulting protein (isoform 2) is shorter and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    BC038807, DA050598
    Consensus CDS
    CCDS58746.1
    UniProtKB/Swiss-Prot
    Q96Q40
    Related
    ENSP00000412775.1, ENST00000434439.1
    Conserved Domains (2) summary
    PLN00009
    Location:103390
    PLN00009; cyclin-dependent kinase A; Provisional
    cd07870
    Location:102387
    STKc_PFTAIRE2; Catalytic domain of the Serine/Threonine Kinase, PFTAIRE-2 kinase
  3. NM_001366386.2NP_001353315.1  cyclin-dependent kinase 15 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC007242, AC007358
    Related
    ENSP00000498608.2, ENST00000652192.3
    Conserved Domains (1) summary
    cd07870
    Location:102387
    STKc_PFTAIRE2; Catalytic domain of the Serine/Threonine Kinase, PFTAIRE-2 kinase
  4. NM_139158.2NP_631897.1  cyclin-dependent kinase 15 isoform 3

    See identical proteins and their annotated locations for NP_631897.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has an alternate in-frame 5' exon and initiates translation at an upstream AUG compared to variant 1. This results in a shorter protein (isoform 3) with a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AB053308, AC007242, AC007358
    Consensus CDS
    CCDS2350.1
    UniProtKB/Swiss-Prot
    Q96Q40
    Related
    ENSP00000260967.2, ENST00000260967.6
    Conserved Domains (2) summary
    PLN00009
    Location:52339
    PLN00009; cyclin-dependent kinase A; Provisional
    cd07870
    Location:51336
    STKc_PFTAIRE2; Catalytic domain of the Serine/Threonine Kinase, PFTAIRE-2 kinase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    201790324..201895550
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005246782.4XP_005246839.1  cyclin-dependent kinase 15 isoform X3

    See identical proteins and their annotated locations for XP_005246839.1

    UniProtKB/Swiss-Prot
    Q96Q40
    Related
    ENSP00000386901.3, ENST00000410091.7
    Conserved Domains (2) summary
    PLN00009
    Location:52339
    PLN00009; cyclin-dependent kinase A; Provisional
    cd07870
    Location:51336
    STKc_PFTAIRE2; Catalytic domain of the Serine/Threonine Kinase, PFTAIRE-2 kinase
  2. XM_011511652.1XP_011509954.1  cyclin-dependent kinase 15 isoform X4

    Conserved Domains (2) summary
    smart00220
    Location:103338
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:102367
    PKc_like; Protein Kinases, catalytic domain
  3. XM_011511650.2XP_011509952.1  cyclin-dependent kinase 15 isoform X2

    Conserved Domains (2) summary
    PLN00009
    Location:103390
    PLN00009; cyclin-dependent kinase A; Provisional
    cd07870
    Location:102387
    STKc_PFTAIRE2; Catalytic domain of the Serine/Threonine Kinase, PFTAIRE-2 kinase
  4. XM_011511654.2XP_011509956.1  cyclin-dependent kinase 15 isoform X5

    Conserved Domains (1) summary
    cl21453
    Location:102338
    PKc_like; Protein Kinases, catalytic domain
  5. XM_011511656.2XP_011509958.1  cyclin-dependent kinase 15 isoform X6

    See identical proteins and their annotated locations for XP_011509958.1

    Conserved Domains (1) summary
    cl21453
    Location:1207
    PKc_like; Protein Kinases, catalytic domain
  6. XM_011511655.2XP_011509957.1  cyclin-dependent kinase 15 isoform X6

    See identical proteins and their annotated locations for XP_011509957.1

    Conserved Domains (1) summary
    cl21453
    Location:1207
    PKc_like; Protein Kinases, catalytic domain
  7. XM_011511657.2XP_011509959.1  cyclin-dependent kinase 15 isoform X7

    Conserved Domains (1) summary
    cl21453
    Location:12197
    PKc_like; Protein Kinases, catalytic domain

RNA

  1. XR_922990.1 RNA Sequence

  2. XR_922991.2 RNA Sequence

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