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Aqp9 aquaporin 9 [ Rattus norvegicus (Norway rat) ]

Gene ID: 65054, updated on 26-Jan-2021

Summary

Official Symbol
Aqp9provided by RGD
Official Full Name
aquaporin 9provided by RGD
Primary source
RGD:68433
See related
Ensembl:ENSRNOG00000061883
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
solute channel involved in passage of carbamides, polyols, purines, and pyrimidines [RGD, Feb 2006]
Expression
Biased expression in Liver (RPKM 685.9) and Testes (RPKM 41.9) See more
Orthologs
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Genomic context

See Aqp9 in Genome Data Viewer
Location:
8q24
Exon count:
12
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (71797231..71837485, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (77559621..77599781, complement)

Chromosome 8 - NC_051343.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120094202 Neighboring gene lipase C, hepatic type Neighboring gene similar to HS1-associating protein X-1 (HAX-1) (HS1-binding protein) Neighboring gene aldehyde dehydrogenase 1 family, member A2 Neighboring gene RNA polymerase II subunit M

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Homology

Clone Names

  • MGC93419

Gene Ontology Provided by RGD

Function Evidence Code Pubs
glycerol channel activity ISO
Inferred from Sequence Orthology
more info
 
glycerol channel activity ISS
Inferred from Sequence or Structural Similarity
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
purine nucleobase transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
pyrimidine nucleobase transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
urea channel activity ISO
Inferred from Sequence Orthology
more info
 
urea channel activity ISS
Inferred from Sequence or Structural Similarity
more info
 
urea transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
water channel activity IDA
Inferred from Direct Assay
more info
PubMed 
water channel activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
amine transport ISO
Inferred from Sequence Orthology
more info
 
canalicular bile acid transport IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to cAMP ISO
Inferred from Sequence Orthology
more info
 
glycerol transport ISO
Inferred from Sequence Orthology
more info
 
glycerol transport ISS
Inferred from Sequence or Structural Similarity
more info
 
polyol transport ISO
Inferred from Sequence Orthology
more info
 
purine nucleobase transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
purine nucleobase transport ISO
Inferred from Sequence Orthology
more info
 
pyrimidine nucleobase transport ISO
Inferred from Sequence Orthology
more info
 
pyrimidine-containing compound transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
response to mercury ion ISO
Inferred from Sequence Orthology
more info
 
response to organic substance ISO
Inferred from Sequence Orthology
more info
 
urea transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
urea transmembrane transport ISS
Inferred from Sequence or Structural Similarity
more info
 
water transport IDA
Inferred from Direct Assay
more info
PubMed 
water transport ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
basolateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
integral component of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
integral component of plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
PubMed 
intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
aquaporin-9
Names
AQP-9
aquaglyceroporin-9
neutral solute channel aquaporin 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022960.2NP_075249.1  aquaporin-9

    See identical proteins and their annotated locations for NP_075249.1

    Status: PROVISIONAL

    Source sequence(s)
    BC085731
    UniProtKB/Swiss-Prot
    P56627
    Related
    ENSRNOP00000069377.1, ENSRNOT00000087980.1
    Conserved Domains (1) summary
    cl00200
    Location:4266
    MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051343.1 Reference mRatBN7.2 Primary Assembly

    Range
    71797231..71837485 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039082097.1XP_038938025.1  aquaporin-9 isoform X1

  2. XM_006243362.2XP_006243424.1  aquaporin-9 isoform X1

    See identical proteins and their annotated locations for XP_006243424.1

    UniProtKB/Swiss-Prot
    P56627
    Conserved Domains (1) summary
    cl00200
    Location:4266
    MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...
  3. XM_039082095.1XP_038938023.1  aquaporin-9 isoform X1

  4. XM_039082099.1XP_038938027.1  aquaporin-9 isoform X1

  5. XM_039082100.1XP_038938028.1  aquaporin-9 isoform X1

  6. XM_039082096.1XP_038938024.1  aquaporin-9 isoform X1

  7. XM_008766336.3XP_008764558.1  aquaporin-9 isoform X1

    See identical proteins and their annotated locations for XP_008764558.1

    UniProtKB/Swiss-Prot
    P56627
    Conserved Domains (1) summary
    cl00200
    Location:4266
    MIP; Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal ...
  8. XM_039082098.1XP_038938026.1  aquaporin-9 isoform X1

  9. XM_039082101.1XP_038938029.1  aquaporin-9 isoform X2

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