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Pik3c3 phosphatidylinositol 3-kinase, catalytic subunit type 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 65052, updated on 2-Oct-2018

Summary

Official Symbol
Pik3c3provided by RGD
Official Full Name
phosphatidylinositol 3-kinase, catalytic subunit type 3provided by RGD
Primary source
RGD:620899
See related
Ensembl:ENSRNOG00000017840
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
activation and intracellular signaling mediates leukotriene B4-induced chemotaxis, generation of reactive oxygen species, and degranulation [RGD, Feb 2006]
Expression
Biased expression in Thymus (RPKM 128.6), Kidney (RPKM 122.0) and 9 other tissues See more
Orthologs

Genomic context

See Pik3c3 in Genome Data Viewer
Location:
18p12
Exon count:
25
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (22964121..23047896)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 18 NC_005117.3 (22694862..22778628)

Chromosome 18 - NC_005117.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102546931 Neighboring gene similar to L-lactate dehydrogenase A chain (LDH-A) (LDH muscle subunit) (LDH-M) Neighboring gene uncharacterized LOC108348763 Neighboring gene similar to heat shock protein 8

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
1-phosphatidylinositol-3-kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
1-phosphatidylinositol-3-kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
1-phosphatidylinositol-3-kinase activity ISO
Inferred from Sequence Orthology
more info
 
ATP binding IEA
Inferred from Electronic Annotation
more info
 
kinase activity ISO
Inferred from Sequence Orthology
more info
 
phosphatidylinositol 3-kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
autophagosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
autophagosome assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
autophagosome assembly ISO
Inferred from Sequence Orthology
more info
 
autophagy ISO
Inferred from Sequence Orthology
more info
 
autophagy of peroxisome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell division IEA
Inferred from Electronic Annotation
more info
 
cellular response to glucose starvation ISO
Inferred from Sequence Orthology
more info
 
cellular response to glucose starvation ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to starvation ISO
Inferred from Sequence Orthology
more info
 
early endosome to late endosome transport ISO
Inferred from Sequence Orthology
more info
 
early endosome to late endosome transport ISS
Inferred from Sequence or Structural Similarity
more info
 
endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endosome organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
macroautophagy ISO
Inferred from Sequence Orthology
more info
 
macroautophagy ISS
Inferred from Sequence or Structural Similarity
more info
 
phosphatidylinositol phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatidylinositol-3-phosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatidylinositol-3-phosphate biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
phosphatidylinositol-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatidylinositol-mediated signaling IDA
Inferred from Direct Assay
more info
PubMed 
protein lipidation IEA
Inferred from Electronic Annotation
more info
 
protein lipidation ISO
Inferred from Sequence Orthology
more info
 
protein localization to phagophore assembly site IEA
Inferred from Electronic Annotation
more info
 
protein localization to phagophore assembly site ISO
Inferred from Sequence Orthology
more info
 
protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
protein processing IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cytokinesis ISO
Inferred from Sequence Orthology
more info
 
regulation of cytokinesis ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of protein secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to leucine IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
autolysosome IEA
Inferred from Electronic Annotation
more info
 
autolysosome ISO
Inferred from Sequence Orthology
more info
 
axoneme ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular_component ND
No biological Data available
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IEA
Inferred from Electronic Annotation
more info
 
endosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
late endosome ISO
Inferred from Sequence Orthology
more info
 
late endosome ISS
Inferred from Sequence or Structural Similarity
more info
 
membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
midbody ISO
Inferred from Sequence Orthology
more info
 
midbody ISS
Inferred from Sequence or Structural Similarity
more info
 
peroxisome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phagocytic vesicle IEA
Inferred from Electronic Annotation
more info
 
phagocytic vesicle ISO
Inferred from Sequence Orthology
more info
 
phagophore assembly site IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatidylinositol 3-kinase complex, class III ISO
Inferred from Sequence Orthology
more info
 
phosphatidylinositol 3-kinase complex, class III ISS
Inferred from Sequence or Structural Similarity
more info
 
phosphatidylinositol 3-kinase complex, class III, type I IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatidylinositol 3-kinase complex, class III, type II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
phosphatidylinositol 3-kinase catalytic subunit type 3
Names
PI-3K Vps34p
PI3-kinase type 3
PI3K type 3
catalytic phosphatidylinositol 3-kinase 3
phosphoinositide-3-kinase, class 3
ptdIns-3-kinase type 3
NP_075247.1
XP_006254550.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022958.2NP_075247.1  phosphatidylinositol 3-kinase catalytic subunit type 3

    See identical proteins and their annotated locations for NP_075247.1

    Status: PROVISIONAL

    Source sequence(s)
    BC061981
    UniProtKB/Swiss-Prot
    O88763
    Related
    ENSRNOP00000060791.2, ENSRNOT00000066816.2
    Conserved Domains (3) summary
    cd08397
    Location:26186
    C2_PI3K_class_III; C2 domain present in class III phosphatidylinositol 3-kinases (PI3Ks)
    cd00870
    Location:283503
    PI3Ka_III; Phosphoinositide 3-kinase (PI3K) class III, accessory domain (PIK domain); PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3Ks class III ...
    cd00896
    Location:539883
    PI3Kc_III; Catalytic domain of Class III Phosphoinositide 3-kinase

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005117.4 Reference Rnor_6.0 Primary Assembly

    Range
    22964121..23047896
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006254488.3XP_006254550.1  phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X1

    Conserved Domains (3) summary
    cd08397
    Location:26186
    C2_PI3K_class_III; C2 domain present in class III phosphatidylinositol 3-kinases (PI3Ks)
    cd00870
    Location:283502
    PI3Ka_III; Phosphoinositide 3-kinase (PI3K) class III, accessory domain (PIK domain); PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3Ks class III ...
    cd00896
    Location:538882
    PI3Kc_III; Catalytic domain of Class III Phosphoinositide 3-kinase

Alternate Rn_Celera

Genomic

  1. AC_000086.1 Alternate Rn_Celera

    Range
    21624416..21707267
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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