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Fat2 FAT atypical cadherin 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 65048, updated on 19-Apr-2019

Summary

Official Symbol
Fat2provided by RGD
Official Full Name
FAT atypical cadherin 2provided by RGD
Primary source
RGD:620656
See related
Ensembl:ENSRNOG00000012575
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Fath2
Summary
Drosophila and human homolog is a tumor suppressor gene [RGD, Feb 2006]
Annotation information
Annotation category: partial on reference assembly
Expression
Biased expression in Brain (RPKM 161.4) and Thymus (RPKM 46.5) See more
Orthologs

Genomic context

See Fat2 in Genome Data Viewer
Location:
10q22
Exon count:
23
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (40583025..40682598, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 10 NC_005109.3 (40421638..40513778, complement)

Chromosome 10 - NC_005109.4Genomic Context describing neighboring genes Neighboring gene solute carrier family 36 member 2 Neighboring gene solute carrier family 36 member 1 Neighboring gene 40S ribosomal protein S28 pseudogene Neighboring gene secreted protein acidic and cysteine rich

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell-substrate adhesion IEA
Inferred from Electronic Annotation
more info
 
cell-substrate adhesion ISO
Inferred from Sequence Orthology
more info
PubMed 
cell-substrate adhesion ISS
Inferred from Sequence or Structural Similarity
more info
 
epithelial cell migration IEA
Inferred from Electronic Annotation
more info
 
epithelial cell migration ISO
Inferred from Sequence Orthology
more info
PubMed 
epithelial cell migration ISS
Inferred from Sequence or Structural Similarity
more info
 
homophilic cell adhesion via plasma membrane adhesion molecules IDA
Inferred from Direct Assay
more info
PubMed 
homophilic cell adhesion via plasma membrane adhesion molecules IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
cell-cell adherens junction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell-cell adherens junction IEA
Inferred from Electronic Annotation
more info
 
cell-cell adherens junction ISO
Inferred from Sequence Orthology
more info
PubMed 
cell-cell adherens junction ISS
Inferred from Sequence or Structural Similarity
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
protocadherin Fat 2
Names
FAT tumor suppressor homolog 2
MEGF1
multiple EGF-like domains protein 1
multiple epidermal growth factor-like domains 1
multiple epidermal growth factor-like domains protein 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022954.1NP_075243.1  protocadherin Fat 2 precursor

    See identical proteins and their annotated locations for NP_075243.1

    Status: PROVISIONAL

    Source sequence(s)
    AB011527
    UniProtKB/Swiss-Prot
    O88277
    Related
    ENSRNOP00000055459.4, ENSRNOT00000058665.4
    Conserved Domains (6) summary
    cd11304
    Location:33283424
    Cadherin_repeat; Cadherin tandem repeat domain
    cd00054
    Location:39533986
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam00008
    Location:39924022
    EGF; EGF-like domain
    pfam00028
    Location:34333524
    Cadherin; Cadherin domain
    pfam02210
    Location:38023923
    Laminin_G_2; Laminin G domain
    cl09101
    Location:18771959
    E_set; Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005109.4 Reference Rnor_6.0 Primary Assembly

    Range
    40583025..40682598 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000078.1 Alternate Rn_Celera

    Range
    38701431..38790574 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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