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Dlgap1 DLG associated protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 65040, updated on 22-Aug-2021

Summary

Official Symbol
Dlgap1provided by RGD
Official Full Name
DLG associated protein 1provided by RGD
Primary source
RGD:620223
See related
Ensembl:ENSRNOG00000016196
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Gkap; DAP-1; rGKAP; SAPAP1; GKAP/SAPAP1
Summary
binds the guanylate kinase-like domain of the PSD-95 family of synaptic ion channel clustering proteins; may play a role in protein-protein interactions at the synaptic junction [RGD, Feb 2006]
Expression
Biased expression in Brain (RPKM 171.0), Lung (RPKM 19.0) and 4 other tissues See more
Orthologs
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Genomic context

See Dlgap1 in Genome Data Viewer
Location:
9q38
Exon count:
22
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (109857500..110726817)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (118277046..119159807)

Chromosome 9 - NC_051344.1Genomic Context describing neighboring genes Neighboring gene zinc finger protein 161 Neighboring gene A-kinase anchor inhibitor 1 Neighboring gene dephospho-CoA kinase domain-containing protein pseudogene Neighboring gene uncharacterized LOC120094814 Neighboring gene uncharacterized LOC102555426 Neighboring gene uncharacterized LOC102555570 Neighboring gene uncharacterized LOC120094778 Neighboring gene uncharacterized LOC120094777 Neighboring gene TGFB-induced factor homeobox 1

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Component Evidence Code Pubs
is_active_in glutamatergic synapse IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
located_in postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 
located_in postsynaptic density IEA
Inferred from Electronic Annotation
more info
 
located_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynaptic density, intracellular component IDA
Inferred from Direct Assay
more info
PubMed 
located_in postsynaptic density, intracellular component IDA
Inferred from Direct Assay
more info
PubMed 
located_in postsynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in postsynaptic specialization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in synapse ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
disks large-associated protein 1
Names
PSD-95 binding protein
PSD-95/SAP90-binding protein 1
SAP90/PSD-95-associated protein 1
discs large homolog associated protein 1
guanylate kinase-associated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001304287.1NP_001291216.1  disks large-associated protein 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks three 5' exons, contains an alternate 5' terminal exon, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    JACYVU010000215
    UniProtKB/Swiss-Prot
    P97836
    Related
    ENSRNOP00000072852.1, ENSRNOT00000087592.1
    Conserved Domains (1) summary
    pfam03359
    Location:360692
    GKAP; Guanylate-kinase-associated protein (GKAP) protein
  2. NM_022946.3NP_075235.3  disks large-associated protein 1 isoform 1

    See identical proteins and their annotated locations for NP_075235.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    JACYVU010000215
    UniProtKB/TrEMBL
    G3V849
    Related
    ENSRNOP00000022351.7, ENSRNOT00000022351.7
    Conserved Domains (1) summary
    pfam03359
    Location:660992
    GKAP; Guanylate-kinase-associated protein (GKAP) protein

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051344.1 Reference mRatBN7.2 Primary Assembly

    Range
    109857500..110726817
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039084190.1XP_038940118.1  disks large-associated protein 1 isoform X3

    Conserved Domains (1) summary
    pfam03359
    Location:632964
    GKAP; Guanylate-kinase-associated protein (GKAP) protein
  2. XM_017596628.2XP_017452117.1  disks large-associated protein 1 isoform X1

    UniProtKB/TrEMBL
    G3V849
    Conserved Domains (1) summary
    pfam03359
    Location:660992
    GKAP; Guanylate-kinase-associated protein (GKAP) protein
  3. XM_039084189.1XP_038940117.1  disks large-associated protein 1 isoform X1

    Conserved Domains (1) summary
    pfam03359
    Location:660992
    GKAP; Guanylate-kinase-associated protein (GKAP) protein
  4. XM_039084188.1XP_038940116.1  disks large-associated protein 1 isoform X1

    Conserved Domains (1) summary
    pfam03359
    Location:660992
    GKAP; Guanylate-kinase-associated protein (GKAP) protein
  5. XM_017596627.2XP_017452116.1  disks large-associated protein 1 isoform X1

    UniProtKB/TrEMBL
    G3V849
    Conserved Domains (1) summary
    pfam03359
    Location:660992
    GKAP; Guanylate-kinase-associated protein (GKAP) protein
  6. XM_017596630.2XP_017452119.1  disks large-associated protein 1 isoform X2

  7. XM_039084191.1XP_038940119.1  disks large-associated protein 1 isoform X4

    Conserved Domains (1) summary
    pfam03359
    Location:622954
    GKAP; Guanylate-kinase-associated protein (GKAP) protein
  8. XM_039084192.1XP_038940120.1  disks large-associated protein 1 isoform X10

    Conserved Domains (1) summary
    pfam03359
    Location:341673
    GKAP; Guanylate-kinase-associated protein (GKAP) protein
  9. XM_008767429.3XP_008765651.1  disks large-associated protein 1 isoform X5

    Conserved Domains (1) summary
    pfam03359
    Location:379711
    GKAP; Guanylate-kinase-associated protein (GKAP) protein
  10. XM_039084193.1XP_038940121.1  disks large-associated protein 1 isoform X11

    Conserved Domains (1) summary
    pfam03359
    Location:334666
    GKAP; Guanylate-kinase-associated protein (GKAP) protein
  11. XM_008767430.3XP_008765652.1  disks large-associated protein 1 isoform X6

    See identical proteins and their annotated locations for XP_008765652.1

    UniProtKB/Swiss-Prot
    P97836
    Conserved Domains (1) summary
    pfam03359
    Location:362694
    GKAP; Guanylate-kinase-associated protein (GKAP) protein
  12. XM_017596631.2XP_017452120.1  disks large-associated protein 1 isoform X8

  13. XM_008767432.3XP_008765654.1  disks large-associated protein 1 isoform X7

    UniProtKB/Swiss-Prot
    P97836
    Conserved Domains (1) summary
    pfam03359
    Location:352684
    GKAP; Guanylate-kinase-associated protein (GKAP) protein
  14. XM_008767433.3XP_008765655.1  disks large-associated protein 1 isoform X9

    Conserved Domains (1) summary
    pfam03359
    Location:341673
    GKAP; Guanylate-kinase-associated protein (GKAP) protein
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