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Bche butyrylcholinesterase [ Rattus norvegicus (Norway rat) ]

Gene ID: 65036, updated on 13-Aug-2019

Summary

Official Symbol
Bcheprovided by RGD
Official Full Name
butyrylcholinesteraseprovided by RGD
Primary source
RGD:619996
See related
Ensembl:ENSRNOG00000009826
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Expression
Biased expression in Heart (RPKM 176.5), Liver (RPKM 64.0) and 8 other tissues See more
Orthologs

Genomic context

See Bche in Genome Data Viewer
Location:
2q32
Exon count:
4
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (171104476..171196186, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 2 NC_005101.3 (190443044..190536106, complement)

Chromosome 2 - NC_005101.4Genomic Context describing neighboring genes Neighboring gene sucrase-isomaltase Neighboring gene SLIT and NTRK-like family, member 3 Neighboring gene similar to enolase 1, alpha non-neuron Neighboring gene schwannomin interacting protein 1 Neighboring gene aldose reductase-related protein 2-like

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
acetylcholinesterase activity IEA
Inferred from Electronic Annotation
more info
 
acetylcholinesterase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
choline binding IDA
Inferred from Direct Assay
more info
PubMed 
cholinesterase activity IDA
Inferred from Direct Assay
more info
PubMed 
cholinesterase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
identical protein binding IEA
Inferred from Electronic Annotation
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
PubMed 
Process Evidence Code Pubs
choline metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
learning IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of synaptic transmission IDA
Inferred from Direct Assay
more info
PubMed 
neuroblast differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to alkaloid IDA
Inferred from Direct Assay
more info
PubMed 
response to drug IDA
Inferred from Direct Assay
more info
PubMed 
response to folic acid IDA
Inferred from Direct Assay
more info
PubMed 
response to glucocorticoid IDA
Inferred from Direct Assay
more info
PubMed 
response to nutrient IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
PubMed 
endoplasmic reticulum lumen IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
nuclear envelope lumen IEA
Inferred from Electronic Annotation
more info
 
nuclear envelope lumen ISO
Inferred from Sequence Orthology
more info
PubMed 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022942.1NP_075231.1  cholinesterase precursor

    See identical proteins and their annotated locations for NP_075231.1

    Status: PROVISIONAL

    Source sequence(s)
    AF244349
    UniProtKB/TrEMBL
    Q9JKC1
    Related
    ENSRNOP00000013279.2, ENSRNOT00000013279.3
    Conserved Domains (3) summary
    COG0657
    Location:120272
    Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
    pfam00135
    Location:21545
    COesterase; Carboxylesterase family
    pfam08674
    Location:560594
    AChE_tetra; Acetylcholinesterase tetramerization domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005101.4 Reference Rnor_6.0 Primary Assembly

    Range
    171104476..171196186 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000070.1 Alternate Rn_Celera

    Range
    152547587..152638478 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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