U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Dnaja1 DnaJ heat shock protein family (Hsp40) member A1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 65028, updated on 8-Dec-2022

Summary

Official Symbol
Dnaja1provided by RGD
Official Full Name
DnaJ heat shock protein family (Hsp40) member A1provided by RGD
Primary source
RGD:620942
See related
Ensembl:ENSRNOG00000007029 AllianceGenome:RGD:620942
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Hsj2
Summary
Enables ATPase activator activity. Predicted to be involved in several processes, including negative regulation of intracellular signal transduction; negative regulation of protein ubiquitination; and regulation of establishment of protein localization. Predicted to act upstream of or within several processes, including androgen receptor signaling pathway; flagellated sperm motility; and toxin transport. Predicted to be located in membrane and microtubule cytoskeleton. Predicted to be active in cytosol. Orthologous to human DNAJA1 (DnaJ heat shock protein family (Hsp40) member A1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Liver (RPKM 696.9), Kidney (RPKM 559.3) and 9 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Dnaja1 in Genome Data Viewer
Location:
5q22
Exon count:
10
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (55842414..55853326)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (57028467..57039378)

Chromosome 5 - NC_051340.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L24, pseudogene 4 Neighboring gene aprataxin Neighboring gene microRNA 207 Neighboring gene SMU1, DNA replication regulator and spliceosomal factor Neighboring gene beta-1,4-galactosyltransferase 1

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATPase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ATPase activator activity ISO
Inferred from Sequence Orthology
more info
 
enables ATPase activator activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables C3HC4-type RING finger domain binding ISO
Inferred from Sequence Orthology
more info
 
enables G protein-coupled receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables Hsp70 protein binding IEA
Inferred from Electronic Annotation
more info
 
enables Hsp70 protein binding ISO
Inferred from Sequence Orthology
more info
 
enables Hsp70 protein binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables Tat protein binding ISO
Inferred from Sequence Orthology
more info
 
enables chaperone binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables chaperone binding ISO
Inferred from Sequence Orthology
more info
 
enables chaperone binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables low-density lipoprotein particle receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
enables unfolded protein binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within androgen receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within flagellated sperm motility ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of JUN kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of JUN kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of establishment of protein localization to mitochondrion ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein folding IEA
Inferred from Electronic Annotation
more info
 
involved_in protein localization to mitochondrion ISO
Inferred from Sequence Orthology
more info
 
involved_in protein localization to mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein refolding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of protein transport ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of protein transport ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in response to heat IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within spermatogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within toxin transport ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in microtubule cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
dnaJ homolog subfamily A member 1
Names
DnaJ (Hsp40) homolog, subfamily A, member 1
DnaJ-like protein 2
HSJ-2
dnaJ-like protein 1
heat shock protein J2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022934.1NP_075223.1  dnaJ homolog subfamily A member 1

    See identical proteins and their annotated locations for NP_075223.1

    Status: PROVISIONAL

    Source sequence(s)
    U53922
    UniProtKB/Swiss-Prot
    P63036
    Related
    ENSRNOP00000010061.2, ENSRNOT00000010061.4
    Conserved Domains (1) summary
    PTZ00037
    Location:2394
    PTZ00037; DnaJ_C chaperone protein; Provisional

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051340.1 Reference mRatBN7.2 Primary Assembly

    Range
    55842414..55853326
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006238099.3XP_006238161.1  dnaJ homolog subfamily A member 1 isoform X1

    See identical proteins and their annotated locations for XP_006238161.1

    UniProtKB/Swiss-Prot
    P63036
    Related
    ENSRNOP00000079023.1, ENSRNOT00000095533.1
    Conserved Domains (1) summary
    PTZ00037
    Location:2394
    PTZ00037; DnaJ_C chaperone protein; Provisional