Zfp110 zinc finger protein 110 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Zfp110provided by MGI
Official Full Name: zinc finger protein 110provided by MGI
Primary source: MGI:MGI:1890378
See related: Ensembl:ENSMUSG00000058638 AllianceGenome:MGI:1890378
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: NRIF; Nrif1; 2900024E01Rik
Summary: Enables neurotrophin p75 receptor binding activity. Involved in neuron apoptotic process and regulation of JNK cascade. Acts upstream of or within extrinsic apoptotic signaling pathway and retinal cell apoptotic process. Located in cytoplasm and nucleus. Is expressed in early conceptus; eye; genitourinary system; and liver. Orthologous to human ZNF274 (zinc finger protein 274). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in testis adult (RPKM 14.6), bladder adult (RPKM 7.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 A1; 7 7.66 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (12565225..12584513)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (12834761..12850586)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data show that in vitro down regulation of NRIF expression decreased the mRNA for two main cholesterogenic enzymes, 3-hydroxy-3-methylglutaryl-coenzyme A reductase and 7-dehydrocholesterol reductase.
Title: NRIF is a regulator of neuronal cholesterol biosynthesis genes.
NRIF gene expression gradually decreassedas development progressed.
Title: Characterization of NADE, NRIF and SC-1 gene expression during mouse neurogenesis.
These results establish neurotrophin receptor interacting factor (NRIF) as an essential component of the p75 apoptotic pathway.
Title: Neurotrophin receptor interacting factor (NRIF) is an essential mediator of apoptotic signaling by the p75 neurotrophin receptor.
Data demonstrate that NRIF is a substrate for TRAF6-mediated K63 polyubiquitination and that this modification is necessary for its nuclear translocation.
Title: TRAF6-mediated ubiquitination regulates nuclear translocation of NRIF, the p75 receptor interactor.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH137568 (e-PCR)
- UniSTS:219655

N28112 (e-PCR)
- UniSTS:125500

AJ242914 (e-PCR)
- UniSTS:163407

RH125054 (e-PCR)
- UniSTS:161876

AW547636 (e-PCR)
- UniSTS:208063

Homology

Homologs of the Zfp110 gene: The Zfp110 gene is conserved in human, chimpanzee, Rhesus monkey, cow, and rat.
Orthologs from Annotation Pipeline: 170 organisms have orthologs with human gene Zfp110
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables neurotrophin p75 receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within extrinsic apoptotic signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of JNK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within retinal cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: neurotrophin receptor-interacting factor 1

Names: neurotrophin receptor interacting factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001360576.1 → NP_001347505.1 neurotrophin receptor-interacting factor 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.

Source sequence(s)

AC107704

Consensus CDS

CCDS20814.1

UniProtKB/TrEMBL

A0A0R4J249

Conserved Domains (7) summary

smart00349
Location:18 → 77

KRAB; krueppel associated box

sd00017
Location:746 → 766

ZF_C2H2; C2H2 Zn finger [structural motif]

sd00019
Location:663 → 682

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:772 → 794

zf-C2H2; Zinc finger, C2H2 type

pfam01352
Location:283 → 324

KRAB; KRAB box

pfam02023
Location:159 → 246

SCAN; SCAN domain

pfam13465
Location:786 → 811

zf-H2C2_2; Zinc-finger double domain
NM_022981.5 → NP_075357.4 neurotrophin receptor-interacting factor 1

See identical proteins and their annotated locations for NP_075357.4

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.

Source sequence(s)

AC107704, AK013583, CN707582

Consensus CDS

CCDS20814.1

UniProtKB/Swiss-Prot

Q923B3

UniProtKB/TrEMBL

A0A0R4J249

Related

ENSMUSP00000004614.9, ENSMUST00000004614.15

Conserved Domains (7) summary

smart00349
Location:18 → 77

KRAB; krueppel associated box

sd00017
Location:746 → 766

ZF_C2H2; C2H2 Zn finger [structural motif]

sd00019
Location:663 → 682

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:772 → 794

zf-C2H2; Zinc finger, C2H2 type

pfam01352
Location:283 → 324

KRAB; KRAB box

pfam02023
Location:159 → 246

SCAN; SCAN domain

pfam13465
Location:786 → 811

zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

12565225..12584513

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036153328.1 → XP_036009221.1 neurotrophin receptor-interacting factor 1 isoform X1

Conserved Domains (6) summary

sd00017
Location:714 → 734

ZF_C2H2; C2H2 Zn finger [structural motif]

sd00019
Location:631 → 650

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:740 → 762

zf-C2H2; Zinc finger, C2H2 type

pfam01352
Location:251 → 292

KRAB; KRAB box

pfam02023
Location:127 → 209

SCAN; SCAN domain

pfam13465
Location:754 → 779

zf-H2C2_2; Zinc-finger double domain
XM_036153329.1 → XP_036009222.1 neurotrophin receptor-interacting factor 1 isoform X2

Conserved Domains (6) summary

sd00017
Location:668 → 688

ZF_C2H2; C2H2 Zn finger [structural motif]

sd00019
Location:585 → 604

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:694 → 716

zf-C2H2; Zinc finger, C2H2 type

pfam01352
Location:205 → 246

KRAB; KRAB box

pfam02023
Location:81 → 163

SCAN; SCAN domain

pfam13465
Location:708 → 733

zf-H2C2_2; Zinc-finger double domain