U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Zfp110 zinc finger protein 110 [ Mus musculus (house mouse) ]

Gene ID: 65020, updated on 8-May-2024

Summary

Official Symbol
Zfp110provided by MGI
Official Full Name
zinc finger protein 110provided by MGI
Primary source
MGI:MGI:1890378
See related
Ensembl:ENSMUSG00000058638 AllianceGenome:MGI:1890378
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NRIF; Nrif1; 2900024E01Rik
Summary
Enables neurotrophin p75 receptor binding activity. Involved in neuron apoptotic process and regulation of JNK cascade. Acts upstream of or within extrinsic apoptotic signaling pathway and retinal cell apoptotic process. Located in cytoplasm and nucleus. Is expressed in early conceptus; eye; genitourinary system; and liver. Orthologous to human ZNF274 (zinc finger protein 274). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 14.6), bladder adult (RPKM 7.7) and 28 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Zfp110 in Genome Data Viewer
Location:
7 A1; 7 7.66 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (12565225..12584513)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (12834761..12850586)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene zinc finger and SCAN domain containing 18 Neighboring gene zinc finger protein 329 pseudogene Neighboring gene STARR-seq mESC enhancer starr_18057 Neighboring gene zinc finger protein 329 Neighboring gene predicted gene, 45971 Neighboring gene STARR-positive B cell enhancer ABC_E6510 Neighboring gene zinc finger protein 128

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables neurotrophin p75 receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
neurotrophin receptor-interacting factor 1
Names
neurotrophin receptor interacting factor

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360576.1NP_001347505.1  neurotrophin receptor-interacting factor 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AC107704
    Consensus CDS
    CCDS20814.1
    UniProtKB/Swiss-Prot
    Q8BS00, Q923B3, Q9D6I6, Q9QZ07
    UniProtKB/TrEMBL
    A0A0R4J249
    Conserved Domains (7) summary
    smart00349
    Location:1877
    KRAB; krueppel associated box
    sd00017
    Location:746766
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:663682
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:772794
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:283324
    KRAB; KRAB box
    pfam02023
    Location:159246
    SCAN; SCAN domain
    pfam13465
    Location:786811
    zf-H2C2_2; Zinc-finger double domain
  2. NM_022981.5NP_075357.4  neurotrophin receptor-interacting factor 1

    See identical proteins and their annotated locations for NP_075357.4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AC107704, AK013583, CN707582
    Consensus CDS
    CCDS20814.1
    UniProtKB/Swiss-Prot
    Q8BS00, Q923B3, Q9D6I6, Q9QZ07
    UniProtKB/TrEMBL
    A0A0R4J249
    Related
    ENSMUSP00000004614.9, ENSMUST00000004614.15
    Conserved Domains (7) summary
    smart00349
    Location:1877
    KRAB; krueppel associated box
    sd00017
    Location:746766
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:663682
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:772794
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:283324
    KRAB; KRAB box
    pfam02023
    Location:159246
    SCAN; SCAN domain
    pfam13465
    Location:786811
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    12565225..12584513
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036153328.1XP_036009221.1  neurotrophin receptor-interacting factor 1 isoform X1

    UniProtKB/Swiss-Prot
    Q8BS00, Q923B3, Q9D6I6, Q9QZ07
    Conserved Domains (6) summary
    sd00017
    Location:714734
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:631650
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:740762
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:251292
    KRAB; KRAB box
    pfam02023
    Location:127209
    SCAN; SCAN domain
    pfam13465
    Location:754779
    zf-H2C2_2; Zinc-finger double domain
  2. XM_036153329.1XP_036009222.1  neurotrophin receptor-interacting factor 1 isoform X2

    Conserved Domains (6) summary
    sd00017
    Location:668688
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:585604
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:694716
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:205246
    KRAB; KRAB box
    pfam02023
    Location:81163
    SCAN; SCAN domain
    pfam13465
    Location:708733
    zf-H2C2_2; Zinc-finger double domain