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MRPL1 mitochondrial ribosomal protein L1 [ Homo sapiens (human) ]

Gene ID: 65008, updated on 3-May-2020

Summary

Official Symbol
MRPL1provided by HGNC
Official Full Name
mitochondrial ribosomal protein L1provided by HGNC
Primary source
HGNC:HGNC:14275
See related
Ensembl:ENSG00000169288 MIM:611821
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
L1MT; BM022; MRP-L1
Summary
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the L1 ribosomal protein family. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in kidney (RPKM 8.5), heart (RPKM 8.4) and 25 other tissues See more
Orthologs

Genomic context

See MRPL1 in Genome Data Viewer
Location:
4q21.1
Exon count:
10
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (77862680..77952790)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (78783805..78873944)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377297 Neighboring gene CCR4-NOT transcription complex subunit 6 like Neighboring gene uncharacterized LOC102724916 Neighboring gene serine and arginine rich splicing factor 10 pseudogene Neighboring gene high mobility group box 1 pseudogene 44

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ96680

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
structural constituent of ribosome IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
maturation of LSU-rRNA IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrial translational elongation TAS
Traceable Author Statement
more info
 
mitochondrial translational termination TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
90S preribosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
large ribosomal subunit IEA
Inferred from Electronic Annotation
more info
 
mitochondrial inner membrane TAS
Traceable Author Statement
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
39S ribosomal protein L1, mitochondrial
Names
mitochondrial large ribosomal subunit protein uL1m

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020236.4NP_064621.3  39S ribosomal protein L1, mitochondrial precursor

    See identical proteins and their annotated locations for NP_064621.3

    Status: REVIEWED

    Source sequence(s)
    BC014356, BU675164
    Consensus CDS
    CCDS3583.2
    UniProtKB/Swiss-Prot
    Q9BYD6
    Related
    ENSP00000315017.8, ENST00000315567.13
    Conserved Domains (1) summary
    TIGR01170
    Location:97240
    rplA_mito; ribosomal protein uL1, mitochondrial

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    77862680..77952790
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_001741317.1 RNA Sequence

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