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MRPL9 mitochondrial ribosomal protein L9 [ Homo sapiens (human) ]

Gene ID: 65005, updated on 7-Jun-2020

Summary

Official Symbol
MRPL9provided by HGNC
Official Full Name
mitochondrial ribosomal protein L9provided by HGNC
Primary source
HGNC:HGNC:14277
See related
Ensembl:ENSG00000143436 MIM:611824
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
L9mt
Summary
This is a nuclear gene encoding a protein component of the 39S subunit of the mitochondrial ribosome. Alternative splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 8. [provided by RefSeq, Jul 2014]
Expression
Ubiquitous expression in bone marrow (RPKM 15.0), lymph node (RPKM 13.3) and 25 other tissues See more
Orthologs

Genomic context

See MRPL9 in Genome Data Viewer
Location:
1q21.3
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (151759647..151763496, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (151732119..151736040, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 662, pseudogene Neighboring gene ribosomal protein S11 pseudogene 3 Neighboring gene ornithine decarboxylase antizyme 3 Neighboring gene tudor and KH domain containing Neighboring gene chloride nucleotide-sensitive channel 1A pseudogene Neighboring gene TDRKH antisense RNA 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
structural constituent of ribosome NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
mitochondrial translational elongation TAS
Traceable Author Statement
more info
 
mitochondrial translational termination TAS
Traceable Author Statement
more info
 
translation NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
mitochondrial inner membrane TAS
Traceable Author Statement
more info
 
mitochondrial large ribosomal subunit IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial ribosome NAS
Non-traceable Author Statement
more info
PubMed 
mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
39S ribosomal protein L9, mitochondrial
Names
mitochondrial large ribosomal subunit protein bL9m

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001300733.2NP_001287662.1  39S ribosomal protein L9, mitochondrial isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AW452832, BC004517, CF127136
    Consensus CDS
    CCDS72916.1
    UniProtKB/Swiss-Prot
    Q9BYD2
    UniProtKB/TrEMBL
    Q5SZR1
    Related
    ENSP00000357822.3, ENST00000368829.3
    Conserved Domains (1) summary
    pfam01281
    Location:95140
    Ribosomal_L9_N; Ribosomal protein L9, N-terminal domain
  2. NM_031420.4NP_113608.1  39S ribosomal protein L9, mitochondrial isoform 1

    See identical proteins and their annotated locations for NP_113608.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AW452832, BC004517
    Consensus CDS
    CCDS1003.1
    UniProtKB/Swiss-Prot
    Q9BYD2
    Related
    ENSP00000357823.3, ENST00000368830.8
    Conserved Domains (2) summary
    pfam01281
    Location:95140
    Ribosomal_L9_N; Ribosomal protein L9, N-terminal domain
    cl27213
    Location:91219
    Ribosomal_L9_C; Ribosomal protein L9, C-terminal domain

RNA

  1. NR_125331.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site at an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5' most expected start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK026363, BC004517
    Related
    ENST00000467306.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    151759647..151763496 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_921910.2 RNA Sequence

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