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MRPL11 mitochondrial ribosomal protein L11 [ Homo sapiens (human) ]

Gene ID: 65003, updated on 9-Jan-2019

Summary

Official Symbol
MRPL11provided by HGNC
Official Full Name
mitochondrial ribosomal protein L11provided by HGNC
Primary source
HGNC:HGNC:14042
See related
Ensembl:ENSG00000174547 MIM:611826
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
L11MT; CGI-113; MRP-L11
Summary
This nuclear gene encodes a 39S subunit component of the mitochondial ribosome. Alternative splicing results in multiple transcript variants. Pseudogenes for this gene are found on chromosomes 5 and 12. [provided by RefSeq, May 2014]
Expression
Ubiquitous expression in colon (RPKM 11.1), bone marrow (RPKM 8.6) and 25 other tissues See more
Orthologs

Genomic context

See MRPL11 in Genome Data Viewer
Location:
11q13.2
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 11 NC_000011.10 (66435075..66438860, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (66202550..66206310, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene RNA, U1 small nuclear 84, pseudogene Neighboring gene neuronal PAS domain protein 4 Neighboring gene chromosome 5 open reading frame 63 pseudogene Neighboring gene uncharacterized LOC101928069 Neighboring gene pellino E3 ubiquitin protein ligase family member 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

NHGRI GWAS Catalog

Description
Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Rev rev HIV-1 Rev is identified to have a physical interaction with mitochondrial ribosomal protein L11 (MRPL11) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
nucleocapsid gag HIV-1 NC is identified to have a physical interaction with mitochondrial ribosomal protein L11 (MRPL11) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Mitochondrial translation, organism-specific biosystem (from REACTOME)
    Mitochondrial translation, organism-specific biosystemOf the roughly 1000 human mitochondrial proteins only 13 proteins, all of them hydrophobic inner membrane proteins that are components of the oxidative phosphorylation apparatus, are encoded in the m...
  • Mitochondrial translation elongation, organism-specific biosystem (from REACTOME)
    Mitochondrial translation elongation, organism-specific biosystemTranslation elongation proceeds by cycles of aminoacyl-tRNAs binding, peptide bond formation, and displacement of deacylated tRNAs (reviewed in Christian and Spremulli 2012). In each cycle an aminoac...
  • Mitochondrial translation initiation, organism-specific biosystem (from REACTOME)
    Mitochondrial translation initiation, organism-specific biosystemTranslation initiates with the mitochondrial mRNA binding the 28S subunit:MTIF3 (28S subunit:IF-3Mt, 28S subunit:IF3mt) complex together with MTIF2:GTP (IF-2Mt:GTP, IF2mt:GTP) (reviewed in Christian ...
  • Mitochondrial translation termination, organism-specific biosystem (from REACTOME)
    Mitochondrial translation termination, organism-specific biosystemTranslation is terminated when MTRF1L:GTP (MTRF1a:GTP) recognizes a UAA or UAG termination codon in the mRNA at the A site of the ribosome (Soleimanpour-Lichaei et al. 2007, reviewed in Richter et al...
  • Organelle biogenesis and maintenance, organism-specific biosystem (from REACTOME)
    Organelle biogenesis and maintenance, organism-specific biosystemThis module describes the biogenesis of organelles. Organelles are subcellular structures of distinctive morphology and function. The organelles of human cells include: mitochondria, endoplasmic reti...
  • Ribosome, organism-specific biosystem (from KEGG)
    Ribosome, organism-specific biosystem
    Ribosome
  • Ribosome, conserved biosystem (from KEGG)
    Ribosome, conserved biosystem
    Ribosome

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC111024

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
large ribosomal subunit rRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
rRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
structural constituent of ribosome NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
mitochondrial translational elongation TAS
Traceable Author Statement
more info
 
mitochondrial translational termination TAS
Traceable Author Statement
more info
 
ribosomal large subunit assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
translation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
translation NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrial inner membrane TAS
Traceable Author Statement
more info
 
mitochondrial large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrial large ribosomal subunit IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial ribosome NAS
Non-traceable Author Statement
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
39S ribosomal protein L11, mitochondrial
Names
mitochondrial large ribosomal subunit protein uL11m

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016050.5NP_057134.1  39S ribosomal protein L11, mitochondrial isoform a

    See identical proteins and their annotated locations for NP_057134.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AK290084, AL519939, BU597133, BU678208
    Consensus CDS
    CCDS8139.1
    UniProtKB/Swiss-Prot
    Q9Y3B7
    Related
    ENSP00000308897.7, ENST00000310999.11
    Conserved Domains (1) summary
    cd00349
    Location:20155
    Ribosomal_L11; Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal ...
  2. NM_170738.3NP_733934.1  39S ribosomal protein L11, mitochondrial isoform b

    See identical proteins and their annotated locations for NP_733934.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, which results in an isoform (b) that lacks an internal segment of sequence, compared to isoform a.
    Source sequence(s)
    AL519939, BC108277, BU597133, BU678208
    Consensus CDS
    CCDS44655.1
    UniProtKB/Swiss-Prot
    Q9Y3B7
    Related
    ENSP00000415356.2, ENST00000430466.6
    Conserved Domains (1) summary
    cd00349
    Location:16129
    Ribosomal_L11; Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal ...
  3. NM_170739.3NP_733935.1  39S ribosomal protein L11, mitochondrial isoform c

    See identical proteins and their annotated locations for NP_733935.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) includes an additional exon compared to variant 1, which results in a frameshift. It encodes an isoform (c) that is shorter and has a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AK290084, AL519939, BQ020382, BU597133, BU678208
    Consensus CDS
    CCDS8140.1
    UniProtKB/Swiss-Prot
    Q9Y3B7
    Related
    ENSP00000329630.4, ENST00000329819.4
    Conserved Domains (1) summary
    smart00649
    Location:20156
    RL11; Ribosomal protein L11/L12

RNA

  1. NR_120588.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site at an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AP002748
  2. NR_120589.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) uses an alternate splice site at the 5' terminal exon, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.
    Source sequence(s)
    AP002748

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p12 Primary Assembly

    Range
    66435075..66438860 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017018135.2XP_016873624.1  39S ribosomal protein L11, mitochondrial isoform X2

  2. XM_024448661.1XP_024304429.1  39S ribosomal protein L11, mitochondrial isoform X1

    Conserved Domains (1) summary
    smart00649
    Location:20156
    RL11; Ribosomal protein L11/L12
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