Format

Send to:

Choose Destination

SKP1 S-phase kinase associated protein 1 [ Homo sapiens (human) ]

Gene ID: 6500, updated on 1-Jun-2020

Summary

Official Symbol
SKP1provided by HGNC
Official Full Name
S-phase kinase associated protein 1provided by HGNC
Primary source
HGNC:HGNC:10899
See related
Ensembl:ENSG00000113558 MIM:601434
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OCP2; p19A; EMC19; SKP1A; OCP-II; TCEB1L
Summary
This gene encodes a component of SCF complexes, which are composed of this protein, cullin 1, a ring-box protein, and one member of the F-box family of proteins. This protein binds directly to the F-box motif found in F-box proteins. SCF complexes are involved in the regulated ubiquitination of specific protein substrates, which targets them for degradation by the proteosome. Specific F-box proteins recognize different target protein(s), and many specific SCF substrates have been identified including regulators of cell cycle progression and development. Studies have also characterized the protein as an RNA polymerase II elongation factor. Alternative splicing of this gene results in two transcript variants. A related pseudogene has been identified on chromosome 7. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in brain (RPKM 102.0), thyroid (RPKM 75.8) and 25 other tissues See more
Orthologs

Genomic context

See SKP1 in Genome Data Viewer
Location:
5q31.1
Exon count:
5
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (134148935..134177033, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (133492082..133512724, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105379185 Neighboring gene short transmembrane mitochondrial protein 1-like Neighboring gene transcription factor 7 Neighboring gene protein phosphatase 2 catalytic subunit alpha Neighboring gene microRNA 3661 Neighboring gene cyclin dependent kinase like 3 Neighboring gene ribosomal protein S13 pseudogene 6

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vpu vpu HIV-1 Vpu is identified to have a physical interaction with S-phase kinase-associated protein 1 (SKP1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC34403

Gene Ontology Provided by GOA

Function Evidence Code Pubs
beta-catenin binding IDA
Inferred from Direct Assay
more info
PubMed 
cullin family protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cullin family protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding IPI
Inferred from Physical Interaction
more info
PubMed 
contributes_to ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
Fc-epsilon receptor signaling pathway TAS
Traceable Author Statement
more info
 
G2/M transition of mitotic cell cycle TAS
Traceable Author Statement
more info
 
NIK/NF-kappaB signaling TAS
Traceable Author Statement
more info
 
SCF complex assembly TAS
Traceable Author Statement
more info
 
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process TAS
Traceable Author Statement
more info
 
T cell receptor signaling pathway TAS
Traceable Author Statement
more info
 
Wnt signaling pathway TAS
Traceable Author Statement
more info
 
cellular iron ion homeostasis TAS
Traceable Author Statement
more info
 
histone H2A monoubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
interleukin-1-mediated signaling pathway TAS
Traceable Author Statement
more info
 
maintenance of protein location in nucleus IPI
Inferred from Physical Interaction
more info
PubMed 
negative regulation of G2/M transition of mitotic cell cycle TAS
Traceable Author Statement
more info
 
post-translational protein modification TAS
Traceable Author Statement
more info
 
protein polyubiquitination TAS
Traceable Author Statement
more info
 
protein ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
regulation of mitotic cell cycle phase transition TAS
Traceable Author Statement
more info
 
stimulatory C-type lectin receptor signaling pathway TAS
Traceable Author Statement
more info
 
stress-activated MAPK cascade TAS
Traceable Author Statement
more info
 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Cul7-RING ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with PcG protein complex IDA
Inferred from Direct Assay
more info
PubMed 
SCF ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
PubMed 
cell IEA
Inferred from Electronic Annotation
more info
 
centrosome IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
S-phase kinase-associated protein 1
Names
OCP-2
RNA polymerase II elongation factor-like protein OCP2
SIII
cyclin A/CDK2-associated p19
cyclin-A/CDK2-associated protein p19
organ of Corti protein 2
organ of Corti protein II
p19skp1
transcription elongation factor B polypeptide 1-like
NP_008861.2
NP_733779.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006930.3NP_008861.2  S-phase kinase-associated protein 1 isoform a

    See identical proteins and their annotated locations for NP_008861.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript variant but encodes the shorter isoform (a).
    Source sequence(s)
    AI025746, AI028694, BC025673, BC065730, BI670085, BQ632052
    Consensus CDS
    CCDS4172.1
    UniProtKB/Swiss-Prot
    P63208
    Related
    ENSP00000429472.1, ENST00000522552.5
    Conserved Domains (3) summary
    smart00512
    Location:1112
    Skp1; Found in Skp1 protein family
    COG5201
    Location:1153
    SKP1; SCF ubiquitin ligase, SKP1 component [Posttranslational modification, protein turnover, chaperones]
    pfam01466
    Location:86153
    Skp1; Skp1 family, dimerization domain
  2. NM_170679.3NP_733779.1  S-phase kinase-associated protein 1 isoform b

    See identical proteins and their annotated locations for NP_733779.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) utilizes an alternate splice site in the 3' coding region, compared to variant 1. This results in a frameshift and slightly longer protein (isoform b), compared to isoform a.
    Source sequence(s)
    AC011336, AI025746, AI028694, BC065730, BQ632052, Z47087
    Consensus CDS
    CCDS4171.1
    UniProtKB/Swiss-Prot
    P63208
    Related
    ENSP00000231487.8, ENST00000353411.10
    Conserved Domains (2) summary
    pfam01466
    Location:113160
    Skp1; Skp1 family, dimerization domain
    cd18322
    Location:4127
    BTB_POZ_SKP1; BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in S-phase kinase-associated protein 1 (SKP1) and similar proteins

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    134148935..134177033 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center