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MRPL32 mitochondrial ribosomal protein L32 [ Homo sapiens (human) ]

Gene ID: 64983, updated on 19-Sep-2024

Summary

Official Symbol
MRPL32provided by HGNC
Official Full Name
mitochondrial ribosomal protein L32provided by HGNC
Primary source
HGNC:HGNC:14035
See related
Ensembl:ENSG00000106591 MIM:611839; AllianceGenome:HGNC:14035
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
L32mt; bL32m; HSPC283; MRP-L32; bMRP-59b
Summary
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the L32 ribosomal protein family. A pseudogene corresponding to this gene is found on chromosome Xp. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in adrenal (RPKM 30.6), kidney (RPKM 28.9) and 25 other tissues See more
Orthologs
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Genomic context

See MRPL32 in Genome Data Viewer
Location:
7p14.1
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (42932376..42937857)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (43090506..43095986)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (42971975..42977456)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:42950498-42951195 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:42951196-42951892 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25904 Neighboring gene serine-threonine kinase receptor-associated protein-like Neighboring gene chromosome 7 open reading frame 25 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25905 Neighboring gene proteasome 20S subunit alpha 2 Neighboring gene uncharacterized LOC105375253 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25906 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25907 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:43086257-43086757 Neighboring gene Sharpr-MPRA regulatory region 4044 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:43098985-43099585 Neighboring gene uncharacterized LOC107986790 Neighboring gene Sharpr-MPRA regulatory region 5110

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
 
enables structural constituent of ribosome NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in mitochondrial translation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in translation NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
large ribosomal subunit protein bL32m
Names
39S ribosomal protein L32, mitochondrial
mitochondrial large ribosomal subunit protein bL32m
NP_114109.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031903.3NP_114109.1  large ribosomal subunit protein bL32m precursor

    See identical proteins and their annotated locations for NP_114109.1

    Status: REVIEWED

    Source sequence(s)
    AC010132
    Consensus CDS
    CCDS5468.1
    UniProtKB/Swiss-Prot
    Q96Q68, Q9BYC8, Q9P098
    UniProtKB/TrEMBL
    A4D1V4
    Related
    ENSP00000223324.2, ENST00000223324.3
    Conserved Domains (1) summary
    pfam01783
    Location:79126
    Ribosomal_L32p; Ribosomal L32p protein family

RNA

  1. NR_156497.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AB049649, AC010132, AW379023, BM833110, BU687817

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    42932376..42937857
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    43090506..43095986
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)