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MRPL34 mitochondrial ribosomal protein L34 [ Homo sapiens (human) ]

Gene ID: 64981, updated on 21-Dec-2019

Summary

Official Symbol
MRPL34provided by HGNC
Official Full Name
mitochondrial ribosomal protein L34provided by HGNC
Primary source
HGNC:HGNC:14488
See related
Ensembl:ENSG00000130312 MIM:611840
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
L34mt
Summary
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in kidney (RPKM 30.6), duodenum (RPKM 18.7) and 25 other tissues See more
Orthologs

Genomic context

See MRPL34 in Genome Data Viewer
Location:
19p13.11
Exon count:
3
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (17302807..17306843)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (17413616..17417652)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene BRISC and BRCA1 A complex member 1 Neighboring gene ankyrin repeat and LEM domain containing 1 Neighboring gene abhydrolase domain containing 8 Neighboring gene DET1 and DDB1 associated 1 Neighboring gene anoctamin 8 Neighboring gene GTP binding protein 3, mitochondrial

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC2633, MGC24974

Gene Ontology Provided by GOA

Function Evidence Code Pubs
structural constituent of ribosome NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
mitochondrial translational elongation TAS
Traceable Author Statement
more info
 
mitochondrial translational termination TAS
Traceable Author Statement
more info
 
translation NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
mitochondrial inner membrane TAS
Traceable Author Statement
more info
 
mitochondrial large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrial large ribosomal subunit IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial ribosome NAS
Non-traceable Author Statement
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
39S ribosomal protein L34, mitochondrial
Names
MRP-L34
mitochondrial large ribosomal subunit protein bL34m

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_023937.4NP_076426.1  39S ribosomal protein L34, mitochondrial

    See identical proteins and their annotated locations for NP_076426.1

    Status: REVIEWED

    Source sequence(s)
    AC010463
    Consensus CDS
    CCDS12356.1
    UniProtKB/Swiss-Prot
    Q9BQ48
    UniProtKB/TrEMBL
    A0A024R7J4
    Related
    ENSP00000252602.1, ENST00000252602.1
    Conserved Domains (1) summary
    pfam00468
    Location:5091
    Ribosomal_L34; Ribosomal protein L34

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    17302807..17306843
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011528189.2XP_011526491.1  39S ribosomal protein L34, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_011526491.1

    UniProtKB/Swiss-Prot
    Q9BQ48
    UniProtKB/TrEMBL
    A0A024R7J4
    Related
    ENSP00000471820.1, ENST00000594999.1
    Conserved Domains (1) summary
    pfam00468
    Location:5091
    Ribosomal_L34; Ribosomal protein L34
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