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MRPL38 mitochondrial ribosomal protein L38 [ Homo sapiens (human) ]

Gene ID: 64978, updated on 25-Oct-2020

Summary

Official Symbol
MRPL38provided by HGNC
Official Full Name
mitochondrial ribosomal protein L38provided by HGNC
Primary source
HGNC:HGNC:14033
See related
Ensembl:ENSG00000204316 MIM:611844
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
L38MT; RPML3; MRP-L3; HSPC262; MRP-L38
Summary
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in kidney (RPKM 16.0), testis (RPKM 15.9) and 25 other tissues See more
Orthologs

Genomic context

See MRPL38 in Genome Data Viewer
Location:
17q25.1
Exon count:
9
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (75898644..75904884, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (73894724..73901181, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene tripartite motif containing 47 Neighboring gene tripartite motif containing 65 Neighboring gene Sharpr-MPRA regulatory region 10813 Neighboring gene Fas binding factor 1 Neighboring gene acyl-CoA oxidase 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: FBF1

Homology

Clone Names

  • MGC4810, FLJ13996, KIAA1863

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
mitochondrial translational elongation TAS
Traceable Author Statement
more info
 
mitochondrial translational termination TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
mitochondrial inner membrane TAS
Traceable Author Statement
more info
 
mitochondrial large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrial large ribosomal subunit IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
39S ribosomal protein L38, mitochondrial
Names
mitochondrial large ribosomal subunit protein mL38

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032478.4NP_115867.2  39S ribosomal protein L38, mitochondrial precursor

    See identical proteins and their annotated locations for NP_115867.2

    Status: REVIEWED

    Source sequence(s)
    AC087289
    Consensus CDS
    CCDS11733.2
    UniProtKB/Swiss-Prot
    Q96DV4
    Related
    ENSP00000308275.3, ENST00000309352.3
    Conserved Domains (1) summary
    cd00866
    Location:171321
    PEBP_euk; PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in eukaryotes

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    75898644..75904884 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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