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MRPS5 mitochondrial ribosomal protein S5 [ Homo sapiens (human) ]

Gene ID: 64969, updated on 7-Jun-2020

Summary

Official Symbol
MRPS5provided by HGNC
Official Full Name
mitochondrial ribosomal protein S5provided by HGNC
Primary source
HGNC:HGNC:14498
See related
Ensembl:ENSG00000144029 MIM:611972
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
S5mt; MRP-S5
Summary
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S5P family. Pseudogenes corresponding to this gene are found on chromosomes 4q, 5q, and 18q. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in kidney (RPKM 9.5), duodenum (RPKM 9.0) and 25 other tissues See more
Orthologs

Genomic context

See MRPS5 in Genome Data Viewer
Location:
2q11.1
Exon count:
13
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (95085369..95121808, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (95752952..95787754, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene mal, T cell differentiation protein Neighboring gene uncharacterized LOC105373488 Neighboring gene zinc finger protein 514 Neighboring gene zinc finger protein 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
mitochondrial translational elongation TAS
Traceable Author Statement
more info
 
mitochondrial translational termination TAS
Traceable Author Statement
more info
 
translation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
mitochondrial inner membrane TAS
Traceable Author Statement
more info
 
mitochondrial small ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrial small ribosomal subunit IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
28S ribosomal protein S5, mitochondrial
Names
mitochondrial 28S ribosomal protein S5
mitochondrial small ribosomal subunit protein uS5m

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001321995.1NP_001308924.1  28S ribosomal protein S5, mitochondrial isoform b

    Status: REVIEWED

    Source sequence(s)
    AC092835
    Conserved Domains (3) summary
    TIGR01021
    Location:138293
    rpsE_bact; ribosomal protein S5, bacterial/organelle type
    pfam00333
    Location:139204
    Ribosomal_S5; Ribosomal protein S5, N-terminal domain
    pfam03719
    Location:218286
    Ribosomal_S5_C; Ribosomal protein S5, C-terminal domain
  2. NM_001321996.2NP_001308925.1  28S ribosomal protein S5, mitochondrial isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3), along with variant 4, encodes isoform c.
    Source sequence(s)
    AC092835
    Conserved Domains (3) summary
    COG0098
    Location:26207
    RpsE; Ribosomal protein S5 [Translation, ribosomal structure and biogenesis]
    pfam00333
    Location:52117
    Ribosomal_S5; Ribosomal protein S5, N-terminal domain
    pfam03719
    Location:131199
    Ribosomal_S5_C; Ribosomal protein S5, C-terminal domain
  3. NM_001321997.1NP_001308926.1  28S ribosomal protein S5, mitochondrial isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4), along with variant 3, encodes isoform c.
    Source sequence(s)
    AC092835
    Conserved Domains (3) summary
    COG0098
    Location:26207
    RpsE; Ribosomal protein S5 [Translation, ribosomal structure and biogenesis]
    pfam00333
    Location:52117
    Ribosomal_S5; Ribosomal protein S5, N-terminal domain
    pfam03719
    Location:131199
    Ribosomal_S5_C; Ribosomal protein S5, C-terminal domain
  4. NM_031902.5NP_114108.1  28S ribosomal protein S5, mitochondrial isoform a

    See identical proteins and their annotated locations for NP_114108.1

    Status: REVIEWED

    Source sequence(s)
    AC092835
    Consensus CDS
    CCDS2010.1
    UniProtKB/Swiss-Prot
    P82675
    Related
    ENSP00000272418.2, ENST00000272418.7
    Conserved Domains (1) summary
    cl27712
    Location:221373
    Ribosomal_S5; Ribosomal protein S5, N-terminal domain

RNA

  1. NR_136152.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC092835
  2. NR_136153.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC092835

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    95085369..95121808 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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