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MRPS9 mitochondrial ribosomal protein S9 [ Homo sapiens (human) ]

Gene ID: 64965, updated on 1-Jun-2020

Summary

Official Symbol
MRPS9provided by HGNC
Official Full Name
mitochondrial ribosomal protein S9provided by HGNC
Primary source
HGNC:HGNC:14501
See related
Ensembl:ENSG00000135972 MIM:611975
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
S9mt; RPMS9; MRP-S9
Summary
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in heart (RPKM 14.5), testis (RPKM 14.4) and 25 other tissues See more
Orthologs

Genomic context

See MRPS9 in Genome Data Viewer
Location:
2q12.1
Exon count:
12
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (105037469..105099960)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (105654483..105716418)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene VISTA enhancer hs990 Neighboring gene MRPS9 antisense RNA 2 Neighboring gene Sharpr-MPRA regulatory region 1600 Neighboring gene VISTA enhancer hs868 Neighboring gene uncharacterized LOC105373527 Neighboring gene MRPS9 antisense RNA 1 Neighboring gene long intergenic non-protein coding RNA 1918

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Rev rev HIV-1 Rev is identified to have a physical interaction with mitochondrial ribosomal protein S9 (MRPS9) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
DNA damage response, detection of DNA damage NAS
Non-traceable Author Statement
more info
PubMed 
mitochondrial translational elongation TAS
Traceable Author Statement
more info
 
mitochondrial translational termination TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
mitochondrial inner membrane TAS
Traceable Author Statement
more info
 
mitochondrial small ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrial small ribosomal subunit ISS
Inferred from Sequence or Structural Similarity
more info
 
mitochondrial small ribosomal subunit NAS
Non-traceable Author Statement
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
 
nucleolus IDA
Inferred from Direct Assay
more info
 
small ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
28S ribosomal protein S9, mitochondrial
Names
mitochondrial small ribosomal subunit protein uS9m

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_182640.3NP_872578.1  28S ribosomal protein S9, mitochondrial

    See identical proteins and their annotated locations for NP_872578.1

    Status: REVIEWED

    Source sequence(s)
    BC036575, BC057240, DT217261
    Consensus CDS
    CCDS2065.1
    UniProtKB/Swiss-Prot
    P82933
    Related
    ENSP00000258455.3, ENST00000258455.8
    Conserved Domains (1) summary
    pfam00380
    Location:274396
    Ribosomal_S9; Ribosomal protein S9/S16

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    105037469..105099960
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011511644.2XP_011509946.1  28S ribosomal protein S9, mitochondrial isoform X1

    Conserved Domains (1) summary
    pfam00380
    Location:150272
    Ribosomal_S9; Ribosomal protein S9/S16

RNA

  1. XR_001738903.2 RNA Sequence

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