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MRPS11 mitochondrial ribosomal protein S11 [ Homo sapiens (human) ]

Gene ID: 64963, updated on 7-Jun-2020

Summary

Official Symbol
MRPS11provided by HGNC
Official Full Name
mitochondrial ribosomal protein S11provided by HGNC
Primary source
HGNC:HGNC:14050
See related
Ensembl:ENSG00000181991 MIM:611977
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HCC-2; S11mt; MRP-S11
Summary
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that contains a high level of sequence similarity with ribosomal protein S11P family members. A pseudogene corresponding to this gene is found on chromosome 20. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2016]
Expression
Ubiquitous expression in thyroid (RPKM 4.3), brain (RPKM 3.6) and 25 other tissues See more
Orthologs

Genomic context

See MRPS11 in Genome Data Viewer
Location:
15q25.3
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (88467708..88480776)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (89010684..89021861)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene VISTA enhancer hs2510 Neighboring gene mitochondrial ribosomal protein L46 Neighboring gene DET1 partner of COP1 E3 ubiquitin ligase Neighboring gene long intergenic non-protein coding RNA 1586 Neighboring gene apoptosis enhancing nuclease

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ22512, FLJ23406

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
mRNA 5'-UTR binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
small ribosomal subunit rRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
structural constituent of ribosome ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Process Evidence Code Pubs
DNA damage response, detection of DNA damage NAS
Non-traceable Author Statement
more info
PubMed 
maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrial translation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
mitochondrial translational elongation TAS
Traceable Author Statement
more info
 
mitochondrial translational termination TAS
Traceable Author Statement
more info
 
ribosomal small subunit assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
translation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytosolic small ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrial inner membrane TAS
Traceable Author Statement
more info
 
mitochondrial small ribosomal subunit IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial small ribosomal subunit ISS
Inferred from Sequence or Structural Similarity
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
28S ribosomal protein S11, mitochondrial
Names
cervical cancer proto-oncogene 2 protein
mitochondrial small ribosomal subunit protein uS11m

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001321970.2NP_001308899.1  28S ribosomal protein S11, mitochondrial isoform c

    Status: REVIEWED

    Source sequence(s)
    AC013489, BC012489
    UniProtKB/Swiss-Prot
    P82912
    Conserved Domains (2) summary
    cl00332
    Location:84192
    Ribosomal_S11; Ribosomal protein S11
    cl26081
    Location:29103
    Pribosyltran_N; N-terminal domain of ribose phosphate pyrophosphokinase
  2. NM_001321972.2NP_001308901.1  28S ribosomal protein S11, mitochondrial isoform d

    Status: REVIEWED

    Source sequence(s)
    AC013489, AC142401
    UniProtKB/Swiss-Prot
    P82912
    Conserved Domains (1) summary
    cl00332
    Location:50158
    Ribosomal_S11; Ribosomal protein S11
  3. NM_001321973.2NP_001308902.1  28S ribosomal protein S11, mitochondrial isoform e

    Status: REVIEWED

    Source sequence(s)
    AB049944, AC013489, BM966864, CD172722
    UniProtKB/Swiss-Prot
    P82912
  4. NM_001321974.2NP_001308903.1  28S ribosomal protein S11, mitochondrial isoform f

    Status: REVIEWED

    Source sequence(s)
    AB049944, AC013489, CD172722
    UniProtKB/Swiss-Prot
    P82912
    Related
    ENST00000560850.1
  5. NM_001321976.2NP_001308905.1  28S ribosomal protein S11, mitochondrial isoform g

    Status: REVIEWED

    Source sequence(s)
    AC013489, AC142401, CD172722
    UniProtKB/Swiss-Prot
    P82912
  6. NM_022839.5NP_073750.2  28S ribosomal protein S11, mitochondrial isoform a

    See identical proteins and their annotated locations for NP_073750.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) is the predominant variant and it encodes isoform a.
    Source sequence(s)
    AB049944, AC013489
    Consensus CDS
    CCDS10342.1
    UniProtKB/Swiss-Prot
    P82912
    Related
    ENSP00000317376.4, ENST00000325844.9
    Conserved Domains (2) summary
    cl00332
    Location:85193
    Ribosomal_S11; Ribosomal protein S11
    cl26081
    Location:30104
    Pribosyltran_N; N-terminal domain of ribose phosphate pyrophosphokinase
  7. NM_176805.4NP_789775.1  28S ribosomal protein S11, mitochondrial isoform b

    See identical proteins and their annotated locations for NP_789775.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame internal segment of coding sequence, compared to variant 1, which causes the predicted protein (isoform b) to be shorter than isoform a. The predicted ORF of this rare transcript has not been experimentally confirmed.
    Source sequence(s)
    AB049944, AC013489, BC009451
    Consensus CDS
    CCDS10343.1
    UniProtKB/Swiss-Prot
    P82912
    Related
    ENSP00000318054.7, ENST00000353598.6
    Conserved Domains (1) summary
    cl00332
    Location:74160
    Ribosomal_S11; Ribosomal protein S11

RNA

  1. NR_135915.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC013489, DA803430
  2. NR_135917.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AB049944, AC013489, AC142401
  3. NR_135918.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AB049944, AC013489, AC142401, BE621879

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    88467708..88480776
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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