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MRPS15 mitochondrial ribosomal protein S15 [ Homo sapiens (human) ]

Gene ID: 64960, updated on 25-Jan-2022


Official Symbol
MRPS15provided by HGNC
Official Full Name
mitochondrial ribosomal protein S15provided by HGNC
Primary source
See related
Ensembl:ENSG00000116898 MIM:611979; AllianceGenome:HGNC:14504
Gene type
protein coding
RefSeq status
Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DC37; S15mt; RPMS15; MPR-S15
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S15P family. The encoded protein is more than two times the size of its E. coli counterpart, with the 12S rRNA binding sites conserved. Between human and mouse, the encoded protein is the least conserved among small subunit ribosomal proteins. Pseudogenes corresponding to this gene are found on chromosomes 15q and 19q. [provided by RefSeq, Jul 2008]
Broad expression in testis (RPKM 75.5), fat (RPKM 37.0) and 25 other tissues See more
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Genomic context

See MRPS15 in Genome Data Viewer
Exon count:
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (36455718..36464384, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (36921319..36929985, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA, H/ACA box 63C Neighboring gene organic solute carrier partner 1 Neighboring gene uncharacterized LOC107984940 Neighboring gene Sharpr-MPRA regulatory region 11440 Neighboring gene colony stimulating factor 3 receptor Neighboring gene Sharpr-MPRA regulatory region 4345

Genomic regions, transcripts, and products


  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem


Products Interactant Other Gene Complex Source Pubs Description

General gene information



Clone Names

  • FLJ11564

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables structural constituent of ribosome ISS
Inferred from Sequence or Structural Similarity
more info
enables structural constituent of ribosome NAS
Non-traceable Author Statement
more info
Process Evidence Code Pubs
involved_in mitochondrial translation ISS
Inferred from Sequence or Structural Similarity
more info
involved_in translation NAS
Non-traceable Author Statement
more info
Component Evidence Code Pubs
located_in mitochondrial inner membrane TAS
Traceable Author Statement
more info
part_of mitochondrial small ribosomal subunit IDA
Inferred from Direct Assay
more info
located_in mitochondrion IDA
Inferred from Direct Assay
more info
located_in nucleolus IDA
Inferred from Direct Assay
more info
located_in nucleoplasm IDA
Inferred from Direct Assay
more info

General protein information

Preferred Names
28S ribosomal protein S15, mitochondrial
mitochondrial small ribosomal subunit protein uS15m

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031280.4NP_112570.2  28S ribosomal protein S15, mitochondrial

    See identical proteins and their annotated locations for NP_112570.2

    Status: REVIEWED

    Source sequence(s)
    AC119675, AK315441, BC031336, BM048518, BU927793, CF123360
    Consensus CDS
    ENSP00000362208.5, ENST00000373116.6
    Conserved Domains (1) summary
    Ribosomal_S15; Ribosomal protein S15

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly


  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    36455718..36464384 complement
    GenBank, FASTA, Sequence Viewer (Graphics)
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