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MRPS26 mitochondrial ribosomal protein S26 [ Homo sapiens (human) ]

Gene ID: 64949, updated on 7-Sep-2023


Official Symbol
MRPS26provided by HGNC
Official Full Name
mitochondrial ribosomal protein S26provided by HGNC
Primary source
See related
Ensembl:ENSG00000125901 MIM:611988; AllianceGenome:HGNC:14045
Gene type
protein coding
RefSeq status
Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
mS26; GI008; MRPS13; RPMS13; MRP-S13; MRP-S26; NY-BR-87; C20orf193; dJ534B8.3
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein. This gene lies adjacent to and downstream of the gonadotropin-releasing hormone precursor gene. [provided by RefSeq, Jul 2008]
Ubiquitous expression in kidney (RPKM 22.8), prostate (RPKM 22.4) and 25 other tissues See more
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Genomic context

See MRPS26 in Genome Data Viewer
Exon count:
Annotation release Status Assembly Chr Location
RS_2023_03 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (3046052..3048250)
RS_2023_03 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (3076798..3078996)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (3026698..3028896)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene VPS16 core subunit of CORVET and HOPS complexes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:2852243-2852874 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:2852875-2853504 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:2853505-2854136 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:2854137-2854766 Neighboring gene protein tyrosine phosphatase receptor type A Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:2903375-2903875 Neighboring gene Sharpr-MPRA regulatory region 1396 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr20:3007535-3008734 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:3039761-3040262 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:3040263-3040762 Neighboring gene gonadotropin releasing hormone 2 Neighboring gene uncharacterized LOC101929098 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:3053517-3054052 Neighboring gene CRISPRi-validated cis-regulatory element chr20.213 Neighboring gene oxytocin/neurophysin I prepropeptide Neighboring gene arginine vasopressin

Genomic regions, transcripts, and products


  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem


Products Interactant Other Gene Complex Source Pubs Description

General protein information

Preferred Names
small ribosomal subunit protein mS26; 28S ribosomal protein S26, mitochondrial
28S ribosomal protein S13, mitochondrial
mitochondrial small ribosomal subunit protein mS26
serologically defined breast cancer antigen NY-BR-87

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_030811.4NP_110438.1  small ribosomal subunit protein mS26

    See identical proteins and their annotated locations for NP_110438.1

    Status: REVIEWED

    Source sequence(s)
    BC013018, BI115733
    Consensus CDS
    Q96Q58, Q9BYN8
    ENSP00000369682.3, ENST00000380325.4
    Conserved Domains (1) summary
    MRP-S26; Mitochondrial ribosome subunit S26

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_03

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly


  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047440390.1XP_047296346.1  28S ribosomal protein S26, mitochondrial isoform X1

Alternate T2T-CHM13v2.0


  1. NC_060944.1 Alternate T2T-CHM13v2.0

    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054323885.1XP_054179860.1  28S ribosomal protein S26, mitochondrial isoform X1