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CENPH centromere protein H [ Homo sapiens (human) ]

Gene ID: 64946, updated on 7-Jun-2020

Summary

Official Symbol
CENPHprovided by HGNC
Official Full Name
centromere protein Hprovided by HGNC
Primary source
HGNC:HGNC:17268
See related
Ensembl:ENSG00000153044 MIM:605607
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Centromere and kinetochore proteins play a critical role in centromere structure, kinetochore formation, and sister chromatid separation. The protein encoded by this gene colocalizes with inner kinetochore plate proteins CENP-A and CENP-C in both interphase and metaphase. It localizes outside of centromeric heterochromatin, where CENP-B is localized, and inside the kinetochore corona, where CENP-E is localized during prometaphase. It is thought that this protein can bind to itself, as well as to CENP-A, CENP-B or CENP-C. Multimers of the protein localize constitutively to the inner kinetochore plate and play an important role in the organization and function of the active centromere-kinetochore complex. [provided by RefSeq, Jul 2008]
Expression
Broad expression in testis (RPKM 14.9), bone marrow (RPKM 9.5) and 20 other tissues See more
Orthologs

Genomic context

See CENPH in Genome Data Viewer
Location:
5q13.2
Exon count:
9
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (69189583..69210357)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (68485375..68506184)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112267932 Neighboring gene cyclin B1 Neighboring gene Sharpr-MPRA regulatory region 51 Neighboring gene mitochondrial ribosomal protein S36 Neighboring gene cyclin dependent kinase 7 Neighboring gene coiled-coil domain containing 125

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vpr vpr HIV-1 Vpr and p300/HAT co-localizes with CENP-A and CENP-H proteins in the centromere and arm region of chromosome PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
kinetochore binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
kinetochore binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
CENP-A containing nucleosome assembly TAS
Traceable Author Statement
more info
 
chromosome segregation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
kinetochore assembly IEA
Inferred from Electronic Annotation
more info
 
kinetochore organization TAS
Traceable Author Statement
more info
PubMed 
mitotic spindle organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
condensed chromosome kinetochore IEA
Inferred from Electronic Annotation
more info
 
cytosol TAS
Traceable Author Statement
more info
 
kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
kinetochore IDA
Inferred from Direct Assay
more info
PubMed 
kinetochore IMP
Inferred from Mutant Phenotype
more info
PubMed 
kinetochore NAS
Non-traceable Author Statement
more info
PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
centromere protein H
Names
CENP-H
interphase centromere complex protein 35
kinetochore protein CENP-H

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022909.4NP_075060.1  centromere protein H

    See identical proteins and their annotated locations for NP_075060.1

    Status: REVIEWED

    Source sequence(s)
    AC022107
    Consensus CDS
    CCDS3998.1
    UniProtKB/Swiss-Prot
    Q9H3R5
    UniProtKB/TrEMBL
    A0A0S2Z5T0
    Related
    ENSP00000283006.2, ENST00000283006.7
    Conserved Domains (2) summary
    pfam05837
    Location:126239
    CENP-H; Centromere protein H (CENP-H)
    cl25731
    Location:42208
    PRK10246; exonuclease subunit SbcC; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    69189583..69210357
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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