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CENPH centromere protein H [ Homo sapiens (human) ]

Gene ID: 64946, updated on 3-May-2025
Official Symbol
CENPHprovided by HGNC
Official Full Name
centromere protein Hprovided by HGNC
Primary source
HGNC:HGNC:17268
See related
Ensembl:ENSG00000153044 MIM:605607; AllianceGenome:HGNC:17268
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Centromere and kinetochore proteins play a critical role in centromere structure, kinetochore formation, and sister chromatid separation. The protein encoded by this gene colocalizes with inner kinetochore plate proteins CENP-A and CENP-C in both interphase and metaphase. It localizes outside of centromeric heterochromatin, where CENP-B is localized, and inside the kinetochore corona, where CENP-E is localized during prometaphase. It is thought that this protein can bind to itself, as well as to CENP-A, CENP-B or CENP-C. Multimers of the protein localize constitutively to the inner kinetochore plate and play an important role in the organization and function of the active centromere-kinetochore complex. [provided by RefSeq, Jul 2008]
Expression
Broad expression in testis (RPKM 14.9), bone marrow (RPKM 9.5) and 20 other tissues See more
Orthologs
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See CENPH in Genome Data Viewer
Location:
5q13.2
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (69189583..69210357)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (70012189..70032958)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (68485410..68506184)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA U13 Neighboring gene uncharacterized LOC112267932 Neighboring gene cyclin B1 Neighboring gene Sharpr-MPRA regulatory region 51 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22641 Neighboring gene Sharpr-MPRA regulatory region 69 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:68515812-68516436 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:68530435-68530963 Neighboring gene alpha-ketoglutarate dehydrogenase subunit 4 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:68532675-68533175 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:68545886-68546386 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:68546387-68546887 Neighboring gene cyclin dependent kinase 7 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:68561629-68562129 Neighboring gene coiled-coil domain containing 125

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Vpr vpr HIV-1 Vpr and p300/HAT co-localizes with CENP-A and CENP-H proteins in the centromere and arm region of chromosome PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables kinetochore binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables kinetochore binding IDA
Inferred from Direct Assay
more info
PubMed 
enables kinetochore binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in chromosome segregation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in chromosome segregation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in kinetochore assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in kinetochore organization TAS
Traceable Author Statement
more info
PubMed 
involved_in mitotic spindle organization IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in chromosome IDA
Inferred from Direct Assay
more info
 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
part_of inner kinetochore IPI
Inferred from Physical Interaction
more info
PubMed 
is_active_in kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in kinetochore IDA
Inferred from Direct Assay
more info
PubMed 
located_in kinetochore IEA
Inferred from Electronic Annotation
more info
 
located_in kinetochore IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in kinetochore NAS
Non-traceable Author Statement
more info
PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus NAS
Non-traceable Author Statement
more info
PubMed 
Preferred Names
centromere protein H
Names
CENP-H
interphase centromere complex protein 35
kinetochore protein CENP-H

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022909.4NP_075060.1  centromere protein H

    See identical proteins and their annotated locations for NP_075060.1

    Status: REVIEWED

    Source sequence(s)
    AC022107
    Consensus CDS
    CCDS3998.1
    UniProtKB/Swiss-Prot
    A8K3Y1, Q9H3R5
    UniProtKB/TrEMBL
    A0A0S2Z5T0, B3KVZ3
    Related
    ENSP00000283006.2, ENST00000283006.7
    Conserved Domains (2) summary
    pfam05837
    Location:126239
    CENP-H; Centromere protein H (CENP-H)
    cl25731
    Location:42208
    PRK10246; exonuclease subunit SbcC; Provisional

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    69189583..69210357
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    70012189..70032958
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)