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MRPL14 mitochondrial ribosomal protein L14 [ Homo sapiens (human) ]

Gene ID: 64928, updated on 1-Jun-2020

Summary

Official Symbol
MRPL14provided by HGNC
Official Full Name
mitochondrial ribosomal protein L14provided by HGNC
Primary source
HGNC:HGNC:14279
See related
Ensembl:ENSG00000180992 MIM:611827
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
L14mt; L32mt; MRPL32; RMPL32; RPML32; MRP-L14; MRP-L32
Summary
This nuclear gene encodes a protein component of the 39S subunit of the mitochondrial ribosome. A pseudogene of this gene is found on chromosome 17. [provided by RefSeq, Jan 2016]
Expression
Ubiquitous expression in lung (RPKM 21.5), liver (RPKM 14.0) and 25 other tissues See more
Orthologs

Genomic context

See MRPL14 in Genome Data Viewer
Location:
6p21.1
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (44113451..44127491, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (44081372..44095191, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101929705 Neighboring gene Sharpr-MPRA regulatory region 2143 Neighboring gene ribosomal protein L29 pseudogene 16 Neighboring gene transmembrane protein 63B Neighboring gene uncharacterized LOC107986599 Neighboring gene calpain 11

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies.
NHGRI GWA Catalog
Identification of cis- and trans-acting genetic variants explaining up to half the variation in circulating vascular endothelial growth factor levels.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC70566

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
structural constituent of ribosome IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
mitochondrial translational elongation TAS
Traceable Author Statement
more info
 
mitochondrial translational termination TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
mitochondrial inner membrane TAS
Traceable Author Statement
more info
 
mitochondrial large ribosomal subunit IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
39S ribosomal protein L14, mitochondrial
Names
39S ribosomal protein L32, mitochondrial
mitochondrial large ribosomal subunit protein uL14m

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001318767.1NP_001305696.1  39S ribosomal protein L14, mitochondrial isoform a precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice sites in the 5' UTR compared to variant 1. Variants 1, 2, and 3 encode the same isoform (a).
    Source sequence(s)
    AA887574, AL109615, BM013002, BM559405, BU597168
    Consensus CDS
    CCDS34460.1
    UniProtKB/Swiss-Prot
    Q6P1L8
    UniProtKB/TrEMBL
    A0A024RD78
    Conserved Domains (1) summary
    cl00328
    Location:33142
    Ribosomal_L14; Ribosomal protein L14p/L23e
  2. NM_001318768.1NP_001305697.1  39S ribosomal protein L14, mitochondrial isoform a precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 encode the same isoform (a).
    Source sequence(s)
    AA887574, AL109615, BM013002, CK823336
    Consensus CDS
    CCDS34460.1
    UniProtKB/Swiss-Prot
    Q6P1L8
    UniProtKB/TrEMBL
    A0A024RD78
    Conserved Domains (1) summary
    cl00328
    Location:33142
    Ribosomal_L14; Ribosomal protein L14p/L23e
  3. NM_001318769.1NP_001305698.1  39S ribosomal protein L14, mitochondrial isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and initiates translation at an alternate start codon compared to variant 1. The encoded isoform (b) has a longer N-terminus than isoform a.
    Source sequence(s)
    AA887574, AL109615, AL365192, BM013002, CF541260
    Conserved Domains (1) summary
    cl00328
    Location:43153
    Ribosomal_L14; Ribosomal protein L14p/L23e
  4. NM_001318770.1NP_001305699.1  39S ribosomal protein L14, mitochondrial isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and initiates translation at an alternate start codon compared to variant 1. The encoded isoform (c) has a longer N-terminus than isoform a.
    Source sequence(s)
    AA887574, AL109615, AL365192, BG545603, BM013002
    Conserved Domains (1) summary
    cl00328
    Location:85195
    Ribosomal_L14; Ribosomal protein L14p/L23e
  5. NM_001318771.1NP_001305700.1  39S ribosomal protein L14, mitochondrial isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks an exon in the 5' region and initiates translation at a downstream start codon compared to variant 1. The encoded isoform (d) has a shorter N-terminus than isoform a.
    Source sequence(s)
    AA887574, AL109615, BM013002, BM559405, BU753526
    Conserved Domains (1) summary
    cl00328
    Location:2108
    Ribosomal_L14; Ribosomal protein L14p/L23e
  6. NM_032111.4NP_115487.2  39S ribosomal protein L14, mitochondrial isoform a precursor

    See identical proteins and their annotated locations for NP_115487.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform a. Variants 1, 2, and 3 encode the same isoform (a).
    Source sequence(s)
    AA887574, AL109615, BM559405
    Consensus CDS
    CCDS34460.1
    UniProtKB/Swiss-Prot
    Q6P1L8
    UniProtKB/TrEMBL
    A0A024RD78
    Related
    ENSP00000361084.3, ENST00000372014.5
    Conserved Domains (1) summary
    cl00328
    Location:33142
    Ribosomal_L14; Ribosomal protein L14p/L23e

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    44113451..44127491 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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