Format

Send to:

Choose Destination

PAPOLG poly(A) polymerase gamma [ Homo sapiens (human) ]

Gene ID: 64895, updated on 22-Aug-2020

Summary

Official Symbol
PAPOLGprovided by HGNC
Official Full Name
poly(A) polymerase gammaprovided by HGNC
Primary source
HGNC:HGNC:14982
See related
Ensembl:ENSG00000115421 MIM:616865
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a member of the poly(A) polymerase family which catalyzes template-independent extension of the 3' end of a DNA/RNA strand. This enzyme shares 60% identity to the well characterized poly(A) polymerase II (PAPII) at the amino acid level. These two enzymes have similar organization of structural and functional domains. This enzyme is exclusively localized in the nucleus and exhibits both nonspecific and CPSF (cleavage and polyadenylation specificity factor)/AAUAAA-dependent polyadenylation activity. This gene is located on chromosome 2 in contrast to the PAPII gene, which is located on chromosome 14. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in thyroid (RPKM 5.8), testis (RPKM 3.7) and 25 other tissues See more
Orthologs

Genomic context

See PAPOLG in Genome Data Viewer
Location:
2p16.1
Exon count:
22
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (60756248..60802086)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (60983365..61029221)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 612, pseudogene Neighboring gene ATPase Na+/K+ transporting subunit beta 3 pseudogene 1 Neighboring gene RNA, 7SL, cytoplasmic 632, pseudogene Neighboring gene long intergenic non-protein coding RNA 1185 Neighboring gene ribosomal protein L21 pseudogene 33

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci.
GeneReviews: Not available
Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat The poly(A) site in the HIV-1 5'-LTR is occluded in a Tat-dependent manner, suggesting a role for Tat in regulating this nucleotide signal PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ11805, FLJ12972, FLJ13482, FLJ14187, MGC133307, MGC133308

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
RNA binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IDA
Inferred from Direct Assay
more info
PubMed 
polynucleotide adenylyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
polynucleotide adenylyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
RNA polyadenylation IDA
Inferred from Direct Assay
more info
PubMed 
mRNA polyadenylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
 
membrane HDA PubMed 
nuclear body IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
poly(A) polymerase gamma
Names
PAP-gamma
SRP RNA 3' adenylating enzyme/pap2
SRP RNA 3'-adenylating enzyme
SRP RNA-adenylating enzyme
neo-PAP
neo-poly(A) polymerase
nuclear poly(A) polymerase gamma
polynucleotide adenylyltransferase gamma
signal recognition particle RNA-adenylating enzyme
NP_075045.2
XP_005264557.1
XP_005264558.1
XP_011531343.1
XP_016860212.1
XP_016860213.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022894.4NP_075045.2  poly(A) polymerase gamma

    See identical proteins and their annotated locations for NP_075045.2

    Status: REVIEWED

    Source sequence(s)
    AB209304, AC011245, AI419423, BC111701, DB082179
    Consensus CDS
    CCDS1863.1
    UniProtKB/Swiss-Prot
    Q9BWT3
    Related
    ENSP00000238714.3, ENST00000238714.8
    Conserved Domains (2) summary
    pfam04926
    Location:365503
    PAP_RNA-bind; Poly(A) polymerase predicted RNA binding domain
    pfam04928
    Location:20363
    PAP_central; Poly(A) polymerase central domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    60756248..60802086
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005264500.4XP_005264557.1  poly(A) polymerase gamma isoform X1

    See identical proteins and their annotated locations for XP_005264557.1

    UniProtKB/Swiss-Prot
    Q9BWT3
    Conserved Domains (3) summary
    PTZ00418
    Location:3554
    PTZ00418; Poly(A) polymerase; Provisional
    pfam04926
    Location:365504
    PAP_RNA-bind; Poly(A) polymerase predicted RNA binding domain
    pfam04928
    Location:20363
    PAP_central; Poly(A) polymerase central domain
  2. XM_017004723.2XP_016860212.1  poly(A) polymerase gamma isoform X3

    Conserved Domains (2) summary
    pfam04926
    Location:127266
    PAP_RNA-bind; Poly(A) polymerase predicted RNA binding domain
    cl11966
    Location:1125
    NT_Pol-beta-like; Nucleotidyltransferase (NT) domain of DNA polymerase beta and similar proteins
  3. XM_017004724.2XP_016860213.1  poly(A) polymerase gamma isoform X4

    Related
    ENSP00000405570.1, ENST00000412217.1
  4. XM_005264501.2XP_005264558.1  poly(A) polymerase gamma isoform X2

    See identical proteins and their annotated locations for XP_005264558.1

    Conserved Domains (2) summary
    pfam04926
    Location:321460
    PAP_RNA-bind; Poly(A) polymerase predicted RNA binding domain
    pfam04928
    Location:1319
    PAP_central; Poly(A) polymerase central domain
  5. XM_011533041.1XP_011531343.1  poly(A) polymerase gamma isoform X3

    Related
    ENST00000496283.5
    Conserved Domains (2) summary
    pfam04926
    Location:127266
    PAP_RNA-bind; Poly(A) polymerase predicted RNA binding domain
    cl11966
    Location:1125
    NT_Pol-beta-like; Nucleotidyltransferase (NT) domain of DNA polymerase beta and similar proteins
Support Center