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CDCP1 CUB domain containing protein 1 [ Homo sapiens (human) ]

Gene ID: 64866, updated on 17-May-2020

Summary

Official Symbol
CDCP1provided by HGNC
Official Full Name
CUB domain containing protein 1provided by HGNC
Primary source
HGNC:HGNC:24357
See related
Ensembl:ENSG00000163814 MIM:611735
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CD318; TRASK; SIMA135
Summary
This gene encodes a transmembrane protein which contains three extracellular CUB domains and acts as a substrate for Src family kinases. The protein plays a role in the tyrosine phosphorylation-dependent regulation of cellular events that are involved in tumor invasion and metastasis. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]
Expression
Broad expression in esophagus (RPKM 12.2), skin (RPKM 11.1) and 15 other tissues See more
Orthologs

Genomic context

See CDCP1 in Genome Data Viewer
Location:
3p21.31
Exon count:
9
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (45082277..45146422, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (45123766..45187914, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene zinc finger DHHC-type palmitoyltransferase 3 Neighboring gene exosome component 7 Neighboring gene C-type lectin domain family 3 member B Neighboring gene RNA, U5B small nuclear 3, pseudogene Neighboring gene ribosomal protein S24 pseudogene 8 Neighboring gene uncharacterized LOC101928636

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
extracellular region IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
CUB domain-containing protein 1
Names
membrane glycoprotein gp140
subtractive immunization M plus HEp3-associated 135 kDa protein
transmembrane and associated with src kinases

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022842.5NP_073753.3  CUB domain-containing protein 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_073753.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AY026461, AY167484
    Consensus CDS
    CCDS2727.1
    UniProtKB/Swiss-Prot
    Q9H5V8
    Related
    ENSP00000296129.1, ENST00000296129.6
    Conserved Domains (1) summary
    cl00049
    Location:225297
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
  2. NM_178181.2NP_835488.1  CUB domain-containing protein 1 isoform 2 precursor

    See identical proteins and their annotated locations for NP_835488.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) transcribes past a splice site that is used in variant 1. This results in a novel 3' coding region and 3' UTR, compared to variant 1. It encodes isoform 2 which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AY358779, BC021099
    Consensus CDS
    CCDS46812.1
    UniProtKB/Swiss-Prot
    Q9H5V8
    Related
    ENSP00000399342.2, ENST00000425231.2
    Conserved Domains (1) summary
    cl00049
    Location:225297
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    45082277..45146422 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024453718.1XP_024309486.1  CUB domain-containing protein 1 isoform X3

    Conserved Domains (1) summary
    cl00049
    Location:159231
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
  2. XM_017007070.1XP_016862559.1  CUB domain-containing protein 1 isoform X2

  3. XM_011534024.1XP_011532326.1  CUB domain-containing protein 1 isoform X1

    Conserved Domains (1) summary
    cl00049
    Location:224296
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
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