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NABP1 nucleic acid binding protein 1 [ Homo sapiens (human) ]

Gene ID: 64859, updated on 13-Mar-2020

Summary

Official Symbol
NABP1provided by HGNC
Official Full Name
nucleic acid binding protein 1provided by HGNC
Primary source
HGNC:HGNC:26232
See related
Ensembl:ENSG00000173559 MIM:612103
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SSB2; OBFC2A; SOSS-B2
Summary
Single-stranded DNA (ssDNA)-binding proteins, such as OBFC2A, are ubiquitous and essential for a variety of DNA metabolic processes, including replication, recombination, and detection and repair of damage (Richard et al., 2008 [PubMed 18449195]).[supplied by OMIM, Jun 2008]
Expression
Broad expression in appendix (RPKM 17.5), spleen (RPKM 12.9) and 21 other tissues See more
Orthologs

Genomic context

See NABP1 in Genome Data Viewer
Location:
2q32.3
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (191678072..191690667)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (192542798..192553248)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985833 Neighboring gene CRISPRi-validated cis-regulatory element chr2.5925 Neighboring gene NABP1 3'UTR overlapping transcript 1 Neighboring gene uncharacterized LOC105373811 Neighboring gene uncharacterized LOC105373812

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Phenotypes

NHGRI GWAS Catalog

Description
Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-analysis.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Clone Names

  • FLJ13624, FLJ22833, MGC111163, DKFZp667M1322

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
single-stranded DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
DNA repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to DNA damage stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
double-strand break repair via homologous recombination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
double-strand break repair via homologous recombination IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitotic cell cycle checkpoint IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitotic cell cycle checkpoint IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to ionizing radiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to ionizing radiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
snRNA transcription by RNA polymerase II TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
SOSS complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
SOSS complex IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
nuclear chromosome, telomeric region IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear chromosome, telomeric region ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
SOSS complex subunit B2
Names
oligonucleotide/oligosaccharide-binding fold containing 2A
oligonucleotide/oligosaccharide-binding fold-containing protein 2A
sensor of single-strand DNA complex subunit B2
sensor of ssDNA subunit B2
single-stranded DNA-binding protein 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001031716.4NP_001026886.1  SOSS complex subunit B2 isoform 1

    See identical proteins and their annotated locations for NP_001026886.1

    Status: VALIDATED

    Source sequence(s)
    AC114778
    Consensus CDS
    CCDS33352.1
    UniProtKB/Swiss-Prot
    Q96AH0
    Related
    ENSP00000403683.2, ENST00000425611.7
    Conserved Domains (1) summary
    cd04491
    Location:2299
    SoSSB_OBF; SoSSB_OBF: A subfamily of OB folds similar to the OB fold of the crenarchaeote Sulfolobus solfataricus single-stranded (ss) DNA-binding protein (SSoSSB). SSoSSB has a single OB fold, and it physically and functionally interacts with RNA polymerase. In ...
  2. NM_001254736.2NP_001241665.1  SOSS complex subunit B2 isoform 2

    See identical proteins and their annotated locations for NP_001241665.1

    Status: VALIDATED

    Source sequence(s)
    AC114778
    Consensus CDS
    CCDS58745.1
    UniProtKB/Swiss-Prot
    Q96AH0
    Related
    ENSP00000387243.1, ENST00000410026.6

RNA

  1. NR_045622.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC114778
  2. NR_045623.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC114778

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    191678072..191690667
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_022837.1: Suppressed sequence

    Description
    NM_022837.1: This RefSeq was permanently suppressed because it is a nonsense-mediated decay (NMD) candidate.
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