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NABP1 nucleic acid binding protein 1 [ Homo sapiens (human) ]

Gene ID: 64859, updated on 5-Aug-2022

Summary

Official Symbol
NABP1provided by HGNC
Official Full Name
nucleic acid binding protein 1provided by HGNC
Primary source
HGNC:HGNC:26232
See related
Ensembl:ENSG00000173559 MIM:612103; AllianceGenome:HGNC:26232
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SSB2; OBFC2A; SOSS-B2; NABP1-OT1
Summary
Single-stranded DNA (ssDNA)-binding proteins, such as OBFC2A, are ubiquitous and essential for a variety of DNA metabolic processes, including replication, recombination, and detection and repair of damage (Richard et al., 2008 [PubMed 18449195]).[supplied by OMIM, Jun 2008]
Expression
Broad expression in appendix (RPKM 17.5), spleen (RPKM 12.9) and 21 other tissues See more
Orthologs
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Genomic context

See NABP1 in Genome Data Viewer
Location:
2q32.3
Exon count:
8
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (191678136..191686943)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (192167017..192175824)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (192542862..192551669)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124905959 Neighboring gene Sharpr-MPRA regulatory region 14503 Neighboring gene uncharacterized LOC124900605 Neighboring gene uncharacterized LOC124908062

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-analysis.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Clone Names

  • FLJ13624, FLJ22833, FLJ26671, MGC111163, DKFZp667M1322

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables single-stranded DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
part_of SOSS complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of SOSS complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of SOSS complex IPI
Inferred from Physical Interaction
more info
PubMed 
located_in chromosome, telomeric region ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in site of double-strand break IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
SOSS complex subunit B2
Names
NABP1 3'UTR overlapping transcript 1
lncRNA AK130181
oligonucleotide/oligosaccharide-binding fold containing 2A
oligonucleotide/oligosaccharide-binding fold-containing protein 2A
sensor of single-strand DNA complex subunit B2
sensor of ssDNA subunit B2
single-stranded DNA-binding protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001031716.5NP_001026886.1  SOSS complex subunit B2 isoform 1

    See identical proteins and their annotated locations for NP_001026886.1

    Status: VALIDATED

    Source sequence(s)
    AC114778
    Consensus CDS
    CCDS33352.1
    UniProtKB/Swiss-Prot
    Q96AH0, Q9H5X6
    Related
    ENSP00000403683.2, ENST00000425611.9
    Conserved Domains (1) summary
    cd04491
    Location:2299
    SoSSB_OBF; A subfamily of OB folds similar to the OB fold of the crenarchaeote Sulfolobus solfataricus single-stranded (ss) DNA-binding protein (SSoSSB). SSoSSB has a single OB fold, and it physically and functionally interacts with RNA polymerase. In vitro, SSoSSB ...
  2. NM_001254736.3NP_001241665.1  SOSS complex subunit B2 isoform 2

    See identical proteins and their annotated locations for NP_001241665.1

    Status: VALIDATED

    Source sequence(s)
    AC114778
    Consensus CDS
    CCDS58745.1
    UniProtKB/Swiss-Prot
    Q96AH0
    Related
    ENSP00000387243.1, ENST00000410026.7

RNA

  1. NR_045622.3 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC114778
    Related
    ENST00000307834.9
  2. NR_045623.3 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC114778

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    191678136..191686943
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047445531.1XP_047301487.1  SOSS complex subunit B2 isoform X1

  2. XM_047445532.1XP_047301488.1  SOSS complex subunit B2 isoform X1

    Related
    ENSP00000390901.1, ENST00000451500.5

RNA

  1. XR_007080680.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    192167017..192175824
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NR_131917.1: Suppressed sequence

    Description
    NR_131917.1: This RefSeq was removed because currently there is insufficient support for the transcript.