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TUT1 terminal uridylyl transferase 1, U6 snRNA-specific [ Homo sapiens (human) ]

Gene ID: 64852, updated on 21-Dec-2019

Summary

Official Symbol
TUT1provided by HGNC
Official Full Name
terminal uridylyl transferase 1, U6 snRNA-specificprovided by HGNC
Primary source
HGNC:HGNC:26184
See related
Ensembl:ENSG00000149016 Ensembl:ENSG00000255508 MIM:610641
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PAPD2; RBM21; TENT1; URLC6; TUTase; STARPAP
Summary
This gene encodes a nucleotidyl transferase that functions as both a terminal uridylyltransferase and a nuclear poly(A) polymerase. The encoded enzyme specifically adds and removes nucleotides from the 3' end of small nuclear RNAs and select mRNAs and may function in controlling gene expression and cell proliferation.[provided by RefSeq, Apr 2009]
Expression
Ubiquitous expression in testis (RPKM 10.1), spleen (RPKM 7.4) and 25 other tissues See more
Orthologs

Genomic context

See TUT1 in Genome Data Viewer
Location:
11q12.3
Exon count:
9
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (62575052..62591523, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (62341431..62359109, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene AHNAK nucleoprotein Neighboring gene eukaryotic translation elongation factor 1 gamma Neighboring gene microRNA 6747 Neighboring gene metastasis associated 1 family member 2 Neighboring gene EMAP like 3 Neighboring gene retinal outer segment membrane protein 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Expression of HIV-1 Tat upregulates the abundance of terminal uridylyl transferase 1 (TUT1) in the nucleoli of Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: EEF1G

Homology

Clone Names

  • FLJ21850, FLJ22267, FLJ22347, MGC131987, MGC149809

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
RNA uridylyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
mRNA 3'-UTR binding IDA
Inferred from Direct Assay
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
polynucleotide adenylyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
NOT histone mRNA catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
mRNA polyadenylation IDA
Inferred from Direct Assay
more info
PubMed 
mRNA polyadenylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
pre-mRNA cleavage required for polyadenylation IDA
Inferred from Direct Assay
more info
PubMed 
snRNA processing IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
 
colocalizes_with mRNA cleavage and polyadenylation specificity factor complex IDA
Inferred from Direct Assay
more info
PubMed 
nuclear speck IDA
Inferred from Direct Assay
more info
PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
speckle targeted PIP5K1A-regulated poly(A) polymerase
Names
PAP-associated domain-containing 2
RNA uridylyltransferase
RNA-binding motif protein 21
RNA-binding protein 21
TUTase 6
U6 snRNA-specific terminal uridylyltransferase 1
U6-TUTase
nuclear speckle targeted phosphatidylinositol 4-phosphate 5-kinase type I-alpha regulated-poly(A) polymerase
nuclear speckle-targeted PIPK1A-regulated-poly(A) polymerase
poly(A) polymerase associated domain containing 2
star-PAP
up-regulated in lung cancer 6
NP_001354835.1
NP_073741.3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001367906.1NP_001354835.1  speckle targeted PIP5K1A-regulated poly(A) polymerase isoform 2

    Status: REVIEWED

    Source sequence(s)
    AP002990
    Related
    ENSP00000456163.1, ENST00000496634.2
  2. NM_022830.3NP_073741.3  speckle targeted PIP5K1A-regulated poly(A) polymerase isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AP002990
    Consensus CDS
    CCDS8021.2
    Related
    ENSP00000419607.1, ENST00000476907.6

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    62575052..62591523 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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