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SPATA20 spermatogenesis associated 20 [ Homo sapiens (human) ]

Gene ID: 64847, updated on 23-Nov-2021

Summary

Official Symbol
SPATA20provided by HGNC
Official Full Name
spermatogenesis associated 20provided by HGNC
Primary source
HGNC:HGNC:26125
See related
Ensembl:ENSG00000006282 MIM:613939
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SSP411; Tisp78; HEL-S-98
Expression
Broad expression in testis (RPKM 59.2), thyroid (RPKM 34.4) and 25 other tissues See more
Orthologs
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Genomic context

See SPATA20 in Genome Data Viewer
Location:
17q21.33
Exon count:
17
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (50547174..50555852)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (48624535..48633213)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene MYCBP associated protein Neighboring gene uncharacterized LOC105371824 Neighboring gene epsin 3 Neighboring gene CACNA1G antisense RNA 1 Neighboring gene calcium voltage-gated channel subunit alpha1 G Neighboring gene uncharacterized LOC101927253

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ21347, FLJ21969, MGC111032, DKFZp686H1839

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
spermatogenesis-associated protein 20
Names
epididymis secretory protein Li 98
sperm protein SSP411
sperm-specific protein 411
transcript increased in spermiogenesis 78

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001258372.2NP_001245301.1  spermatogenesis-associated protein 20 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001245301.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 5' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    BC025255, BC111029, BM787432
    Consensus CDS
    CCDS58563.1
    UniProtKB/Swiss-Prot
    Q8TB22
    Related
    ENSP00000348878.4, ENST00000356488.8
    Conserved Domains (3) summary
    COG1331
    Location:57784
    YyaL; Uncharacterized conserved protein YyaL, SSP411 family, contains thoiredoxin and six-hairpin glycosidase-like domains [General function prediction only]
    pfam03190
    Location:62223
    Thioredox_DsbH; Protein of unknown function, DUF255
    cl23840
    Location:276395
    AGE; AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is ...
  2. NM_001258373.2NP_001245302.1  spermatogenesis-associated protein 20 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site and initiates translation at a downstream, in-frame start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus, compared to variant 1.
    Source sequence(s)
    BC025255, BC065526, DA295930
    Consensus CDS
    CCDS58564.1
    UniProtKB/Swiss-Prot
    Q8TB22
    Related
    ENSP00000483295.1, ENST00000619622.4
    Conserved Domains (3) summary
    COG1331
    Location:13740
    YyaL; Uncharacterized conserved protein YyaL, SSP411 family, contains thoiredoxin and six-hairpin glycosidase-like domains [General function prediction only]
    pfam03190
    Location:18179
    Thioredox_DsbH; Protein of unknown function, DUF255
    cl23840
    Location:232351
    AGE; AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is ...
  3. NM_022827.4NP_073738.2  spermatogenesis-associated protein 20 isoform 1 precursor

    See identical proteins and their annotated locations for NP_073738.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    BC025255, BM787432
    Consensus CDS
    CCDS11571.1
    UniProtKB/Swiss-Prot
    Q8TB22
    Related
    ENSP00000006658.6, ENST00000006658.11
    Conserved Domains (3) summary
    COG1331
    Location:73800
    YyaL; Uncharacterized conserved protein YyaL, SSP411 family, contains thoiredoxin and six-hairpin glycosidase-like domains [General function prediction only]
    pfam03190
    Location:78239
    Thioredox_DsbH; Protein of unknown function, DUF255
    cl23840
    Location:292411
    AGE; AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    50547174..50555852
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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