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ISL2 ISL LIM homeobox 2 [ Homo sapiens (human) ]

Gene ID: 64843, updated on 13-Mar-2020

Summary

Official Symbol
ISL2provided by HGNC
Official Full Name
ISL LIM homeobox 2provided by HGNC
Primary source
HGNC:HGNC:18524
See related
Ensembl:ENSG00000159556 MIM:609481
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Low expression observed in reference dataset See more
Orthologs

Genomic context

See ISL2 in Genome Data Viewer
Location:
15q24.3
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (76336773..76342475)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (76629065..76634817)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene electron transfer flavoprotein subunit alpha Neighboring gene CRISPRi-validated cis-regulatory element chr15.2471 Neighboring gene TYRO3P protein tyrosine kinase pseudogene Neighboring gene Sharpr-MPRA regulatory region 228 Neighboring gene tRNA-Lys (anticodon CTT) 16-1 Neighboring gene S-phase cyclin A associated protein in the ER Neighboring gene microRNA 3713

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10160

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
 
DNA-binding transcription factor activity, RNA polymerase II-specific ISM
Inferred from Sequence Model
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
axonogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of neuron differentiation IEA
Inferred from Electronic Annotation
more info
 
neuron development TAS
Traceable Author Statement
more info
PubMed 
neuron fate specification IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peripheral nervous system neuron development TAS
Traceable Author Statement
more info
PubMed 
regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
retinal ganglion cell axon guidance IEA
Inferred from Electronic Annotation
more info
 
spinal cord motor neuron cell fate specification IEA
Inferred from Electronic Annotation
more info
 
visceral motor neuron differentiation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nuclear chromatin ISA
Inferred from Sequence Alignment
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IC
Inferred by Curator
more info
PubMed 

General protein information

Preferred Names
insulin gene enhancer protein ISL-2
Names
ISL2 transcription factor, LIM/homeodomain, (islet-2)
islet-2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145805.3NP_665804.1  insulin gene enhancer protein ISL-2

    See identical proteins and their annotated locations for NP_665804.1

    Status: VALIDATED

    Source sequence(s)
    AC027243, BC012136, DB055557
    Consensus CDS
    CCDS10290.1
    UniProtKB/Swiss-Prot
    Q96A47
    Related
    ENSP00000290759.4, ENST00000290759.9
    Conserved Domains (3) summary
    cd09366
    Location:2781
    LIM1_Isl; The first LIM domain of Isl, a member of LHX protein family
    cd09471
    Location:89143
    LIM2_Isl2; The second LIM domain of Isl2
    smart00389
    Location:191247
    HOX; Homeodomain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    76336773..76342475
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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