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ISL2 ISL LIM homeobox 2 [ Homo sapiens (human) ]

Gene ID: 64843, updated on 11-Jun-2021

Summary

Official Symbol
ISL2provided by HGNC
Official Full Name
ISL LIM homeobox 2provided by HGNC
Primary source
HGNC:HGNC:18524
See related
Ensembl:ENSG00000159556 MIM:609481
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See ISL2 in Genome Data Viewer
Location:
15q24.3
Exon count:
6
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (76336773..76342475)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (76629114..76634816)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene electron transfer flavoprotein subunit alpha Neighboring gene CRISPRi-validated cis-regulatory element chr15.2471 Neighboring gene TYRO3P protein tyrosine kinase pseudogene Neighboring gene Sharpr-MPRA regulatory region 228 Neighboring gene tRNA-Lys (anticodon CTT) 16-1 Neighboring gene S-phase cyclin A associated protein in the ER Neighboring gene microRNA 3713

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10160

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
 
enables cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sequence-specific double-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in axonogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of neuron differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in neuron development TAS
Traceable Author Statement
more info
PubMed 
involved_in neuron fate specification IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in peripheral nervous system neuron development TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in retinal ganglion cell axon guidance IEA
Inferred from Electronic Annotation
more info
 
involved_in spinal cord motor neuron cell fate specification IEA
Inferred from Electronic Annotation
more info
 
involved_in visceral motor neuron differentiation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in chromatin ISA
Inferred from Sequence Alignment
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IC
Inferred by Curator
more info
PubMed 

General protein information

Preferred Names
insulin gene enhancer protein ISL-2
Names
ISL2 transcription factor, LIM/homeodomain, (islet-2)
islet-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145805.3NP_665804.1  insulin gene enhancer protein ISL-2

    See identical proteins and their annotated locations for NP_665804.1

    Status: VALIDATED

    Source sequence(s)
    AC027243, BC012136, DB055557
    Consensus CDS
    CCDS10290.1
    UniProtKB/Swiss-Prot
    Q96A47
    Related
    ENSP00000290759.4, ENST00000290759.9
    Conserved Domains (3) summary
    cd09366
    Location:2781
    LIM1_Isl; The first LIM domain of Isl, a member of LHX protein family
    cd09471
    Location:89143
    LIM2_Isl2; The second LIM domain of Isl2
    smart00389
    Location:191247
    HOX; Homeodomain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    76336773..76342475
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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