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ST3GAL4 ST3 beta-galactoside alpha-2,3-sialyltransferase 4 [ Homo sapiens (human) ]

Gene ID: 6484, updated on 8-Jul-2018
Official Symbol
ST3GAL4provided by HGNC
Official Full Name
ST3 beta-galactoside alpha-2,3-sialyltransferase 4provided by HGNC
Primary source
HGNC:HGNC:10864
See related
Ensembl:ENSG00000110080 MIM:104240; Vega:OTTHUMG00000165830
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
STZ; SAT3; ST-4; CGS23; SIAT4; NANTA3; SIAT4C; ST3GalIV; ST3GalA.2; gal-NAc6S
Summary
This gene encodes a member of the glycosyltransferase 29 family, a group of enzymes involved in protein glycosylation. The encoded protein is targeted to Golgi membranes but may be proteolytically processed and secreted. The gene product may also be involved in the increased expression of sialyl Lewis X antigen seen in inflammatory responses. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Expression
Broad expression in adrenal (RPKM 20.2), ovary (RPKM 18.9) and 23 other tissues See more
Orthologs
See ST3GAL4 in Genome Data Viewer
Location:
11q24.2
Exon count:
17
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 11 NC_000011.10 (126355645..126414641)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (126225540..126284536)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized HP11014 Neighboring gene TIR domain containing adaptor protein Neighboring gene decapping enzyme, scavenger Neighboring gene G-quadruplex forming sequence containing lncRNA Neighboring gene kirre like nephrin family adhesion molecule 3 Neighboring gene uncharacterized LOC101929427 Neighboring gene uncharacterized LOC105369561

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Biological, clinical and population relevance of 95 loci for blood lipids.
NHGRI GWA Catalog
Discovery and refinement of loci associated with lipid levels.
NHGRI GWA Catalog
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.
NHGRI GWA Catalog
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env Oligosaccharide side-chains of HIV-1 gp160 are processed by glycosidase I and II, mannosidase I and II, acetylglucosaminyl transferase I and II, and fucosyl, galactosyl and sialyl transferases in both the endoplasmic reticulum and golgi apparatus PubMed

Go to the HIV-1, Human Interaction Database

  • Asparagine N-linked glycosylation, organism-specific biosystem (from REACTOME)
    Asparagine N-linked glycosylation, organism-specific biosystemN-linked glycosylation is the most important form of post-translational modification for proteins synthesized and folded in the Endoplasmic Reticulum (Stanley et al. 2009). An early study in 1999 rev...
  • Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein, organism-specific biosystem (from REACTOME)
    Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein, organism-specific biosystemN-linked glycosylation commences with the 14-step synthesis of a dolichol lipid-linked oligosaccharide (LLO) consisting of 14 sugars (2 core GlcNAcs, 9 mannoses and 3 terminal GlcNAcs). This pathway ...
  • Glycosaminoglycan metabolism, organism-specific biosystem (from REACTOME)
    Glycosaminoglycan metabolism, organism-specific biosystemGlycosaminoglycans (GAGs) are long, unbranched polysaccharides containing a repeating disaccharide unit composed of a hexosamine (either N-acetylgalactosamine (GalNAc) or N-acetylglucosamine (GlcNAc)...
  • Glycosphingolipid biosynthesis - lacto and neolacto series, organism-specific biosystem (from KEGG)
    Glycosphingolipid biosynthesis - lacto and neolacto series, organism-specific biosystem
    Glycosphingolipid biosynthesis - lacto and neolacto series
  • Glycosphingolipid biosynthesis - lacto and neolacto series, conserved biosystem (from KEGG)
    Glycosphingolipid biosynthesis - lacto and neolacto series, conserved biosystem
    Glycosphingolipid biosynthesis - lacto and neolacto series
  • Keratan sulfate biosynthesis, organism-specific biosystem (from REACTOME)
    Keratan sulfate biosynthesis, organism-specific biosystemKeratan sulfate (KSI) is the best characterised keratan sulfate. It is 10 times more abundant in cornea than cartilage. KSI is attached to an asparagine (Asn) residue on the core protein via an N-lin...
  • Keratan sulfate/keratin metabolism, organism-specific biosystem (from REACTOME)
    Keratan sulfate/keratin metabolism, organism-specific biosystemKeratan sulfate (KS) (a glycosaminoglycan, GAG) is a linear polysaccharide that consists of the repeating disaccharide unit GlcNAc-Gal (N-acetylglucosamine-galactose). KS can perform a structural fun...
  • Metabolic pathways, organism-specific biosystem (from KEGG)
    Metabolic pathways, organism-specific biosystem
    Metabolic pathways
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Metabolism of carbohydrates, organism-specific biosystem (from REACTOME)
    Metabolism of carbohydrates, organism-specific biosystemThese pathways together are responsible for: 1) the extraction of energy and carbon skeletons for biosyntheses from dietary sugars and related molecules; 2) the short-term storage of glucose in the b...
  • Metabolism of proteins, organism-specific biosystem (from REACTOME)
    Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
  • N-Glycan antennae elongation, organism-specific biosystem (from REACTOME)
    N-Glycan antennae elongation, organism-specific biosystemN-glycans are further modified after the commitment to Complex or Hybrid N-glycans. The exact structure of the network of metabolic reactions involved is complex and not yet validated experimentally....
  • N-glycan antennae elongation in the medial/trans-Golgi, organism-specific biosystem (from REACTOME)
    N-glycan antennae elongation in the medial/trans-Golgi, organism-specific biosystemIn the latter compartments of the distal Golgi the N-Glycan is further modified, leading to the wide range of N-Glycans observed in multicellular organisms. The first step of N-Glycan elongation in t...
  • O-linked glycosylation, organism-specific biosystem (from REACTOME)
    O-linked glycosylation, organism-specific biosystemO-glycosylation is an important post-translational modification (PTM) required for correct functioning of many proteins (Van den Steen et al. 1998, Moremen et al. 2012). The O-glycosylation of protei...
  • O-linked glycosylation of mucins, organism-specific biosystem (from REACTOME)
    O-linked glycosylation of mucins, organism-specific biosystemMucins are a family of high molecular weight, heavily glycosylated proteins (glycoconjugates) produced by epithelial tissues in most metazoa. Mucins' key characteristic is their ability to form gels...
  • Post-translational protein modification, organism-specific biosystem (from REACTOME)
    Post-translational protein modification, organism-specific biosystemAfter translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the...
  • Pre-NOTCH Expression and Processing, organism-specific biosystem (from REACTOME)
    Pre-NOTCH Expression and Processing, organism-specific biosystemIn humans and other mammals the NOTCH gene family has four members, NOTCH1, NOTCH2, NOTCH3 and NOTCH4, encoded on four different chromosomes. Their transcription is developmentally regulated and tiss...
  • Pre-NOTCH Processing in Golgi, organism-specific biosystem (from REACTOME)
    Pre-NOTCH Processing in Golgi, organism-specific biosystemNOTCH undergoes final posttranslational processing in the Golgi apparatus (Lardelli et al. 1994, Blaumueller et al. 1997, Weinmaster et al. 1991, Weinmaster et al. 1992, Uyttendaele et al. 1996). Mov...
  • Sialic acid metabolism, organism-specific biosystem (from REACTOME)
    Sialic acid metabolism, organism-specific biosystemSialic acids are a family of 9 carbon alpha-keto acids that are usually present in the non reducing terminal of glycoconjuates on the cell surface of eukaryotic cells. These sialylated conjugates pla...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by NOTCH, organism-specific biosystem (from REACTOME)
    Signaling by NOTCH, organism-specific biosystemThe Notch Signaling Pathway (NSP) is a highly conserved pathway for cell-cell communication. NSP is involved in the regulation of cellular differentiation, proliferation, and specification. For exam...
  • Synthesis of substrates in N-glycan biosythesis, organism-specific biosystem (from REACTOME)
    Synthesis of substrates in N-glycan biosythesis, organism-specific biosystemReactions for the synthesis of the small nucleotide-linked sugar substrates that are used in the synthesis of the N-glycan precursor and in the later steps of glycosylation are annotated here.All the...
  • Termination of O-glycan biosynthesis, organism-specific biosystem (from REACTOME)
    Termination of O-glycan biosynthesis, organism-specific biosystemO-glycan biosynthesis can be terminated (or modified) by the addition of sialic acid residues on Core 1 and 2 glycoproteins by sialyltransferases (Varki et al. 2009).
  • Transport to the Golgi and subsequent modification, organism-specific biosystem (from REACTOME)
    Transport to the Golgi and subsequent modification, organism-specific biosystemAt least two mechanisms of transport of proteins from the ER to the Golgi have been described. One is a general flow requiring no export signals (Wieland et al, 1987; Martinez-Menarguez et al, 1999)....
  • mucin core 1 and core 2 O-glycosylation, organism-specific biosystem (from BIOCYC)
    mucin core 1 and core 2 O-glycosylation, organism-specific biosystemGeneral Background Glycosylation is one of the major types of post-translational modification of proteins, and is an essential process in all eukaryotes. Protein glycosylation is known to be involve...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ11867, FLJ46764

Gene Ontology Provided by GOA

Process Evidence Code Pubs
O-glycan processing TAS
Traceable Author Statement
more info
 
cognition IMP
Inferred from Mutant Phenotype
more info
PubMed 
glycolipid biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
glycoprotein biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
keratan sulfate biosynthetic process TAS
Traceable Author Statement
more info
 
lipid glycosylation IDA
Inferred from Direct Assay
more info
PubMed 
oligosaccharide biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
protein glycosylation IDA
Inferred from Direct Assay
more info
PubMed 
protein sialylation IDA
Inferred from Direct Assay
more info
PubMed 
sialylation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
Golgi cisterna membrane IEA
Inferred from Electronic Annotation
more info
 
Golgi membrane TAS
Traceable Author Statement
more info
 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane HDA PubMed 
Preferred Names
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4
Names
alpha 2,3-ST 4
alpha 2,3-sialyltransferase IV
alpha-3-N-acetylneuraminyltransferase
beta-galactoside alpha-2,3-sialyltransferase 4
gal-beta-1,4-GalNAc-alpha-2,3-sialyltransferase
sialyltransferase 4C (beta-galactosidase alpha-2,3-sialytransferase)
sialyltransferase 4C (beta-galactoside alpha-2,3-sialytransferase)
NP_001241686.1
NP_001241687.1
NP_001241688.1
NP_001335325.1
NP_001335326.1
NP_001335327.1
NP_001335328.1
NP_001335329.1
NP_006269.1
XP_024304426.1
XP_024304427.1
XP_024304428.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_053025.1 RefSeqGene

    Range
    5001..63997
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001254757.1NP_001241686.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 isoform 2

    See identical proteins and their annotated locations for NP_001241686.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2), as well as variants 3 and 8, encodes isoform 2.
    Source sequence(s)
    AL520639, AL529887, AP000806, BI259855, BP320415, DA210431
    Consensus CDS
    CCDS58193.1
    UniProtKB/Swiss-Prot
    Q11206
    Related
    ENSP00000394354.2, OTTHUMP00000231117, ENST00000444328.6, OTTHUMT00000386461
    Conserved Domains (1) summary
    pfam00777
    Location:87331
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  2. NM_001254758.1NP_001241687.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 isoform 2

    See identical proteins and their annotated locations for NP_001241687.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3), as well as variants 2 and 8, encodes isoform 2.
    Source sequence(s)
    AP000806, BC010645
    Consensus CDS
    CCDS58193.1
    UniProtKB/Swiss-Prot
    Q11206
    Related
    ENSP00000376437.2, OTTHUMP00000231123, ENST00000392669.6, OTTHUMT00000386468
    Conserved Domains (1) summary
    pfam00777
    Location:87331
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  3. NM_001254759.1NP_001241688.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 isoform 3 precursor

    See identical proteins and their annotated locations for NP_001241688.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) encodes isoform 3.
    Source sequence(s)
    AP000806, DA841563, L23767
    Consensus CDS
    CCDS58194.1
    UniProtKB/Swiss-Prot
    Q11206
    Related
    ENSP00000434349.1, OTTHUMP00000231126, ENST00000532243.5, OTTHUMT00000386473
    Conserved Domains (1) summary
    pfam00777
    Location:83330
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  4. NM_001348396.1NP_001335325.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5), as well as variant 6, encodes isoform 4.
    Source sequence(s)
    AP000806, AP001318
    Conserved Domains (1) summary
    pfam00777
    Location:108352
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  5. NM_001348397.1NP_001335326.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) represents the longest transcript and encodes the longest isoform (4). Variants 5 and 6 both encode the same isoform (4).
    Source sequence(s)
    AP000806, AP001318
    Conserved Domains (1) summary
    pfam00777
    Location:108352
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  6. NM_001348398.1NP_001335327.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 isoform 5 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) encodes isoform 5.
    Source sequence(s)
    AP000806, AP001318
    Conserved Domains (1) summary
    pfam00777
    Location:83233
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  7. NM_001348399.1NP_001335328.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8), as well as variants 2, and 3, encodes isoform 2.
    Source sequence(s)
    AP000806, AP001318
    Consensus CDS
    CCDS58193.1
    UniProtKB/Swiss-Prot
    Q11206
    Related
    ENSP00000433318.1, ENST00000534083.5
    Conserved Domains (1) summary
    pfam00777
    Location:87331
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  8. NM_001348400.1NP_001335329.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 isoform 1 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9), along with variant 1, encodes isoform 1.
    Source sequence(s)
    AP000806, AP001318
    Consensus CDS
    CCDS8474.1
    UniProtKB/Swiss-Prot
    Q11206
    UniProtKB/TrEMBL
    Q6IBE6
    Related
    ENSP00000227495.6, ENST00000227495.10
    Conserved Domains (1) summary
    pfam00777
    Location:83327
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  9. NM_006278.2NP_006269.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 isoform 1 precursor

    See identical proteins and their annotated locations for NP_006269.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1), as well as variant 9, encodes isoform 1.
    Source sequence(s)
    AP000806, AP001318, X74570
    Consensus CDS
    CCDS8474.1
    UniProtKB/Swiss-Prot
    Q11206
    UniProtKB/TrEMBL
    Q6IBE6
    Related
    ENSP00000433989.1, OTTHUMP00000231118, ENST00000530591.5, OTTHUMT00000386462
    Conserved Domains (1) summary
    pfam00777
    Location:83327
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

RNA

  1. NR_145671.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) does not encode a protein.
    Source sequence(s)
    AP000806, AP001318
    Related
    ENST00000531217.5

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p12 Primary Assembly

    Range
    126355645..126414641
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024448659.1XP_024304427.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 isoform X1

    Conserved Domains (1) summary
    pfam00777
    Location:87331
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  2. XM_024448658.1XP_024304426.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 isoform X1

    Conserved Domains (1) summary
    pfam00777
    Location:87331
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  3. XM_024448660.1XP_024304428.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 isoform X1

    Conserved Domains (1) summary
    pfam00777
    Location:87331
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
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