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ST3GAL4 ST3 beta-galactoside alpha-2,3-sialyltransferase 4 [ Homo sapiens (human) ]

Gene ID: 6484, updated on 12-Jul-2020

Summary

Official Symbol
ST3GAL4provided by HGNC
Official Full Name
ST3 beta-galactoside alpha-2,3-sialyltransferase 4provided by HGNC
Primary source
HGNC:HGNC:10864
See related
Ensembl:ENSG00000110080 MIM:104240
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
STZ; SAT3; ST-4; CGS23; SIAT4; NANTA3; SIAT4C; ST3GalIV; ST3GalA.2; gal-NAc6S
Summary
This gene encodes a member of the glycosyltransferase 29 family, a group of enzymes involved in protein glycosylation. The encoded protein is targeted to Golgi membranes but may be proteolytically processed and secreted. The gene product may also be involved in the increased expression of sialyl Lewis X antigen seen in inflammatory responses. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Expression
Broad expression in adrenal (RPKM 20.2), ovary (RPKM 18.9) and 23 other tissues See more
Orthologs

Genomic context

See ST3GAL4 in Genome Data Viewer
Location:
11q24.2
Exon count:
17
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (126355686..126414641)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (126225540..126284536)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized HP11014 Neighboring gene TIR domain containing adaptor protein Neighboring gene decapping enzyme, scavenger Neighboring gene Sharpr-MPRA regulatory region 5906 Neighboring gene G-quadruplex forming sequence containing lncRNA Neighboring gene kirre like nephrin family adhesion molecule 3 Neighboring gene uncharacterized LOC101929427

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Biological, clinical and population relevance of 95 loci for blood lipids.
NHGRI GWA Catalog
Discovery and refinement of loci associated with lipid levels.
NHGRI GWA Catalog
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.
NHGRI GWA Catalog
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env Oligosaccharide side-chains of HIV-1 gp160 are processed by glycosidase I and II, mannosidase I and II, acetylglucosaminyl transferase I and II, and fucosyl, galactosyl and sialyl transferases in both the endoplasmic reticulum and golgi apparatus PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ11867, FLJ46764

Gene Ontology Provided by GOA

Process Evidence Code Pubs
O-glycan processing TAS
Traceable Author Statement
more info
 
cognition IMP
Inferred from Mutant Phenotype
more info
PubMed 
glycolipid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glycolipid biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
glycoprotein biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
keratan sulfate biosynthetic process TAS
Traceable Author Statement
more info
 
lipid glycosylation IDA
Inferred from Direct Assay
more info
PubMed 
oligosaccharide biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
protein glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein glycosylation IDA
Inferred from Direct Assay
more info
PubMed 
protein sialylation IDA
Inferred from Direct Assay
more info
PubMed 
sialylation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
Golgi cisterna membrane IEA
Inferred from Electronic Annotation
more info
 
Golgi membrane TAS
Traceable Author Statement
more info
 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane HDA PubMed 

General protein information

Preferred Names
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4
Names
alpha 2,3-ST 4
alpha 2,3-sialyltransferase IV
alpha-3-N-acetylneuraminyltransferase
beta-galactoside alpha-2,3-sialyltransferase 4
gal-beta-1,4-GalNAc-alpha-2,3-sialyltransferase
sialyltransferase 4C (beta-galactosidase alpha-2,3-sialytransferase)
sialyltransferase 4C (beta-galactoside alpha-2,3-sialytransferase)
NP_001241686.1
NP_001241687.1
NP_001241688.1
NP_001335325.1
NP_001335326.1
NP_001335327.1
NP_001335328.1
NP_001335329.1
NP_006269.1
XP_024304426.1
XP_024304427.1
XP_024304428.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_053025.1 RefSeqGene

    Range
    5042..63994
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001254757.2NP_001241686.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 isoform 2

    See identical proteins and their annotated locations for NP_001241686.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2), as well as variants 3 and 8, encodes isoform 2.
    Source sequence(s)
    AL520639, AL529887, AP000806, BI259855, BP320415
    Consensus CDS
    CCDS58193.1
    UniProtKB/Swiss-Prot
    Q11206
    Related
    ENSP00000394354.2, ENST00000444328.6
    Conserved Domains (1) summary
    pfam00777
    Location:87331
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  2. NM_001254758.1NP_001241687.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 isoform 2

    See identical proteins and their annotated locations for NP_001241687.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3), as well as variants 2 and 8, encodes isoform 2.
    Source sequence(s)
    AP000806, BC010645
    Consensus CDS
    CCDS58193.1
    UniProtKB/Swiss-Prot
    Q11206
    Related
    ENSP00000376437.2, ENST00000392669.6
    Conserved Domains (1) summary
    pfam00777
    Location:87331
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  3. NM_001254759.2NP_001241688.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 isoform 3 precursor

    See identical proteins and their annotated locations for NP_001241688.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) encodes isoform 3.
    Source sequence(s)
    AP000806, DA841563, L23767
    Consensus CDS
    CCDS58194.1
    UniProtKB/Swiss-Prot
    Q11206
    Related
    ENSP00000434349.1, ENST00000532243.5
    Conserved Domains (1) summary
    pfam00777
    Location:83330
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  4. NM_001348396.2NP_001335325.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5), as well as variant 6, encodes isoform 4.
    Source sequence(s)
    AP000806, AP001318
    Conserved Domains (1) summary
    pfam00777
    Location:108352
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  5. NM_001348397.2NP_001335326.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) represents the longest transcript and encodes the longest isoform (4). Variants 5 and 6 both encode the same isoform (4).
    Source sequence(s)
    AP000806, AP001318
    Conserved Domains (1) summary
    pfam00777
    Location:108352
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  6. NM_001348398.2NP_001335327.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 isoform 5 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) encodes isoform 5.
    Source sequence(s)
    AP000806, AP001318
    Conserved Domains (1) summary
    pfam00777
    Location:83233
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  7. NM_001348399.2NP_001335328.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8), as well as variants 2, and 3, encodes isoform 2.
    Source sequence(s)
    AP000806, AP001318
    Consensus CDS
    CCDS58193.1
    UniProtKB/Swiss-Prot
    Q11206
    Related
    ENSP00000433318.1, ENST00000534083.5
    Conserved Domains (1) summary
    pfam00777
    Location:87331
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  8. NM_001348400.2NP_001335329.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 isoform 1 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9), along with variant 1, encodes isoform 1.
    Source sequence(s)
    AP000806, AP001318
    Consensus CDS
    CCDS8474.1
    UniProtKB/Swiss-Prot
    Q11206
    UniProtKB/TrEMBL
    Q6IBE6
    Related
    ENSP00000227495.6, ENST00000227495.10
    Conserved Domains (1) summary
    pfam00777
    Location:83327
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  9. NM_006278.3NP_006269.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 isoform 1 precursor

    See identical proteins and their annotated locations for NP_006269.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1), as well as variant 9, encodes isoform 1.
    Source sequence(s)
    AP000806, AP001318, X74570
    Consensus CDS
    CCDS8474.1
    UniProtKB/Swiss-Prot
    Q11206
    UniProtKB/TrEMBL
    Q6IBE6
    Related
    ENSP00000433989.1, ENST00000530591.5
    Conserved Domains (1) summary
    pfam00777
    Location:83327
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

RNA

  1. NR_145671.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) does not encode a protein.
    Source sequence(s)
    AP000806, AP001318
    Related
    ENST00000531217.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    126355686..126414641
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024448659.1XP_024304427.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 isoform X1

    Conserved Domains (1) summary
    pfam00777
    Location:87331
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  2. XM_024448658.1XP_024304426.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 isoform X1

    Conserved Domains (1) summary
    pfam00777
    Location:87331
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  3. XM_024448660.1XP_024304428.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4 isoform X1

    Conserved Domains (1) summary
    pfam00777
    Location:87331
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
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