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FNDC4 fibronectin type III domain containing 4 [ Homo sapiens (human) ]

Gene ID: 64838, updated on 11-Jun-2021

Summary

Official Symbol
FNDC4provided by HGNC
Official Full Name
fibronectin type III domain containing 4provided by HGNC
Primary source
HGNC:HGNC:20239
See related
Ensembl:ENSG00000115226 MIM:611905
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FRCP1
Expression
Biased expression in adrenal (RPKM 35.7), brain (RPKM 13.1) and 11 other tissues See more
Orthologs
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Genomic context

See FNDC4 in Genome Data Viewer
Location:
2p23.3
Exon count:
7
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (27491883..27495502, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (27714750..27718067, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene keratinocyte associated protein 3 Neighboring gene intraflagellar transport 172 Neighboring gene RNA, U6 small nuclear 986, pseudogene Neighboring gene glucokinase regulator Neighboring gene Sharpr-MPRA regulatory region 4379

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Common variants in the calcium-sensing receptor gene are associated with total serum calcium levels.
GeneReviews: Not available
Discovery and fine mapping of serum protein loci through transethnic meta-analysis.
GeneReviews: Not available
Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption.
GeneReviews: Not available
Genomic study in Mexicans identifies a new locus for triglycerides and refines European lipid loci.
GeneReviews: Not available
Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways.
GeneReviews: Not available
New loci associated with kidney function and chronic kidney disease.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ22362

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in negative regulation of inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of inflammatory response ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in response to transforming growth factor beta IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in extracellular region IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
fibronectin type III domain-containing protein 4
Names
fibronectin type III repeat-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022823.3NP_073734.1  fibronectin type III domain-containing protein 4 precursor

    See identical proteins and their annotated locations for NP_073734.1

    Status: VALIDATED

    Source sequence(s)
    BC032725, DB452792
    Consensus CDS
    CCDS1756.1
    UniProtKB/Swiss-Prot
    Q9H6D8
    Related
    ENSP00000264703.3, ENST00000264703.4
    Conserved Domains (1) summary
    cd00063
    Location:47137
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    27491883..27495502 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005264499.4XP_005264556.1  fibronectin type III domain-containing protein 4 isoform X1

    Conserved Domains (1) summary
    cd00063
    Location:47137
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
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