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ST3GAL2 ST3 beta-galactoside alpha-2,3-sialyltransferase 2 [ Homo sapiens (human) ]

Gene ID: 6483, updated on 13-Mar-2020

Summary

Official Symbol
ST3GAL2provided by HGNC
Official Full Name
ST3 beta-galactoside alpha-2,3-sialyltransferase 2provided by HGNC
Primary source
HGNC:HGNC:10863
See related
Ensembl:ENSG00000157350 MIM:607188
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SIAT4B; ST3GALII; Gal-NAc6S; ST3GalA.2
Summary
The protein encoded by this gene is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The encoded protein is normally found in the Golgi but can be proteolytically processed to a soluble form. This protein, which is a member of glycosyltransferase family 29, can use the same acceptor substrates as does sialyltransferase 4A. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in appendix (RPKM 6.9), spleen (RPKM 6.8) and 24 other tissues See more
Orthologs

Genomic context

See ST3GAL2 in Genome Data Viewer
Location:
16q22.1
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (70375977..70439100, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (70413338..70472991, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene DEAD-box helicase 19B Neighboring gene uncharacterized LOC100506083 Neighboring gene DEAD-box helicase 19A Neighboring gene ribosomal protein S27 pseudogene 26 Neighboring gene RNA, U6 small nuclear 23, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env Oligosaccharide side-chains of HIV-1 gp160 are processed by glycosidase I and II, mannosidase I and II, acetylglucosaminyl transferase I and II, and fucosyl, galactosyl and sialyl transferases in both the endoplasmic reticulum and golgi apparatus PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
O-glycan processing TAS
Traceable Author Statement
more info
 
glycolipid biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
glycoprotein biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
keratan sulfate biosynthetic process TAS
Traceable Author Statement
more info
 
lipid glycosylation IDA
Inferred from Direct Assay
more info
PubMed 
oligosaccharide biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
protein glycosylation IDA
Inferred from Direct Assay
more info
PubMed 
protein sialylation IDA
Inferred from Direct Assay
more info
PubMed 
sialylation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
Golgi cisterna membrane IEA
Inferred from Electronic Annotation
more info
 
Golgi membrane TAS
Traceable Author Statement
more info
 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2
Names
Gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferase
SIAT4-B
ST3Gal II
alpha 2,3-ST 2
beta-galactoside alpha-2,3-sialyltransferase 2
sialyltransferase 4B (beta-galactosidase alpha-2,3-sialytransferase)
NP_008858.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_046942.1 RefSeqGene

    Range
    5001..64654
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_006927.4NP_008858.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2

    See identical proteins and their annotated locations for NP_008858.1

    Status: REVIEWED

    Source sequence(s)
    AC012184, AK127322, BC036777
    Consensus CDS
    CCDS10890.1
    UniProtKB/Swiss-Prot
    Q16842
    UniProtKB/TrEMBL
    A0A024QZA4, B3KXG9
    Related
    ENSP00000345477.2, ENST00000342907.3
    Conserved Domains (1) summary
    pfam00777
    Location:95348
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    70375977..70439100 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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