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ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 [ Homo sapiens (human) ]

Gene ID: 6482, updated on 1-Jun-2020

Summary

Official Symbol
ST3GAL1provided by HGNC
Official Full Name
ST3 beta-galactoside alpha-2,3-sialyltransferase 1provided by HGNC
Primary source
HGNC:HGNC:10862
See related
Ensembl:ENSG00000008513 MIM:607187
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ST3O; SIAT4A; SIATFL; ST3GalA; ST3GalIA; Gal-NAc6S; ST3GalA.1; ST3GalIA,1
Summary
The protein encoded by this gene is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The encoded protein is normally found in the Golgi but can be proteolytically processed to a soluble form. Correct glycosylation of the encoded protein may be critical to its sialyltransferase activity. This protein, which is a member of glycosyltransferase family 29, can use the same acceptor substrates as does sialyltransferase 4B. Two transcript variants encoding the same protein have been found for this gene. Other transcript variants may exist, but have not been fully characterized yet. [provided by RefSeq, Jul 2008]
Expression
Broad expression in thyroid (RPKM 30.7), kidney (RPKM 13.0) and 22 other tissues See more
Orthologs

Genomic context

See ST3GAL1 in Genome Data Viewer
Location:
8q24.22
Exon count:
11
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (133454848..133572534, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (134467091..134584697, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375771 Neighboring gene uncharacterized LOC105375772 Neighboring gene ST13, Hsp70 interacting protein pseudogene 6 Neighboring gene uncharacterized LOC105375773 Neighboring gene MT-ND2 pseudogene 7

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genetic predictors of risk and resilience in psychiatric disorders: a cross-disorder genome-wide association study of functional impairment in major depressive disorder, bipolar disorder, and schizophrenia.
NHGRI GWA Catalog
Genome-wide association study and meta-analysis of intraocular pressure.
NHGRI GWA Catalog
Genome-wide association study of the five-factor model of personality in young Korean women.
NHGRI GWA Catalog
Genome-wide association study to characterize serum bilirubin elevations in patients with HCV treated with GS-9256, an HCV NS3 serine protease inhibitor.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env Oligosaccharide side-chains of HIV-1 gp160 are processed by glycosidase I and II, mannosidase I and II, acetylglucosaminyl transferase I and II, and fucosyl, galactosyl and sialyl transferases in both the endoplasmic reticulum and golgi apparatus PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC9183, FLJ36548, DKFZp666E036, DKFZp779K2051

Gene Ontology Provided by GOA

Function Evidence Code Pubs
beta-galactoside (CMP) alpha-2,3-sialyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
beta-galactoside (CMP) alpha-2,3-sialyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
beta-galactoside (CMP) alpha-2,3-sialyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
N-acetylneuraminate metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
O-glycan processing TAS
Traceable Author Statement
more info
 
cellular protein modification process TAS
Traceable Author Statement
more info
PubMed 
keratan sulfate biosynthetic process TAS
Traceable Author Statement
more info
 
protein N-linked glycosylation ISS
Inferred from Sequence or Structural Similarity
more info
 
protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
sialylation ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
Golgi cisterna membrane IEA
Inferred from Electronic Annotation
more info
 
Golgi membrane TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane HDA PubMed 

General protein information

Preferred Names
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1
Names
Gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferase
SIAT4-A
ST3GalI
alpha 2,3-ST 1
beta-galactoside alpha-2,3-sialyltransferase 1
sialyltransferase 4A (beta-galactosidase alpha-2,3-sialytransferase)
sialyltransferase 4A (beta-galactoside alpha-2,3-sialyltransferase)
sialyltransferase 4A (beta-galactoside alpha-2,3-sialytransferase)
NP_003024.1
NP_775479.1
XP_005251082.1
XP_006716680.1
XP_011515527.1
XP_016869225.1
XP_024303001.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003033.4NP_003024.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1

    See identical proteins and their annotated locations for NP_003024.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AF186191, BC018357, BX648001
    Consensus CDS
    CCDS6373.1
    UniProtKB/Swiss-Prot
    Q11201
    UniProtKB/TrEMBL
    A0A024R9L6
    Related
    ENSP00000428540.1, ENST00000521180.5
    Conserved Domains (1) summary
    pfam00777
    Location:83338
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  2. NM_173344.3NP_775479.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1

    See identical proteins and their annotated locations for NP_775479.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AF059321, AF186191, BC018357, BX648001, CN359425
    Consensus CDS
    CCDS6373.1
    UniProtKB/Swiss-Prot
    Q11201
    UniProtKB/TrEMBL
    A0A024R9L6
    Related
    ENSP00000430515.1, ENST00000522652.6
    Conserved Domains (1) summary
    pfam00777
    Location:83338
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    133454848..133572534 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006716617.2XP_006716680.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 isoform X1

    See identical proteins and their annotated locations for XP_006716680.1

    UniProtKB/Swiss-Prot
    Q11201
    UniProtKB/TrEMBL
    A0A024R9L6
    Related
    ENSP00000497381.1, ENST00000648219.1
    Conserved Domains (1) summary
    pfam00777
    Location:83338
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  2. XM_011517225.2XP_011515527.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 isoform X1

    See identical proteins and their annotated locations for XP_011515527.1

    UniProtKB/Swiss-Prot
    Q11201
    UniProtKB/TrEMBL
    A0A024R9L6
    Conserved Domains (1) summary
    pfam00777
    Location:83338
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  3. XM_017013736.2XP_016869225.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 isoform X1

    UniProtKB/Swiss-Prot
    Q11201
    UniProtKB/TrEMBL
    A0A024R9L6
    Related
    ENSP00000414073.1, ENST00000399640.3
    Conserved Domains (1) summary
    pfam00777
    Location:83338
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  4. XM_024447233.1XP_024303001.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 isoform X1

    Conserved Domains (1) summary
    pfam00777
    Location:83338
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
  5. XM_005251025.5XP_005251082.1  CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 isoform X1

    See identical proteins and their annotated locations for XP_005251082.1

    UniProtKB/Swiss-Prot
    Q11201
    UniProtKB/TrEMBL
    A0A024R9L6
    Conserved Domains (1) summary
    pfam00777
    Location:83338
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
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