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P2RY12 purinergic receptor P2Y12 [ Homo sapiens (human) ]

Gene ID: 64805, updated on 5-Dec-2019

Summary

Official Symbol
P2RY12provided by HGNC
Official Full Name
purinergic receptor P2Y12provided by HGNC
Primary source
HGNC:HGNC:18124
See related
Ensembl:ENSG00000169313 MIM:600515
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HORK3; P2Y12; ADPG-R; BDPLT8; SP1999; P2T(AC); P2Y(AC); P2Y(12)R; P2Y(ADP); P2Y(cyc)
Summary
The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is involved in platelet aggregation, and is a potential target for the treatment of thromboembolisms and other clotting disorders. Mutations in this gene are implicated in bleeding disorder, platelet type 8 (BDPLT8). Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]
Expression
Biased expression in brain (RPKM 25.8), fat (RPKM 4.8) and 4 other tissues See more
Orthologs

Genomic context

See P2RY12 in Genome Data Viewer
Location:
3q25.1
Exon count:
3
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (151336843..151384812, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (151054631..151102600, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene mediator complex subunit 12L Neighboring gene G protein-coupled receptor 87 Neighboring gene purinergic receptor P2Y13 Neighboring gene immunoglobulin superfamily member 10 Neighboring gene mitochondrial ribosomal protein L42 pseudogene 6 Neighboring gene microRNA 5186

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

  • ADP signalling through P2Y purinoceptor 12, organism-specific biosystem (from REACTOME)
    ADP signalling through P2Y purinoceptor 12, organism-specific biosystemCo-activation of P2Y1 and P2Y12 is necessary for complete platelet activation. P2Y1 is coupled to Gq and helps trigger the release of calcium from internal stores, leading to weak and reversible plat...
  • Class A/1 (Rhodopsin-like receptors), organism-specific biosystem (from REACTOME)
    Class A/1 (Rhodopsin-like receptors), organism-specific biosystemRhodopsin-like receptors (class A/1) are the largest group of GPCRs and are the best studied group from a functional and structural point of view. They show great diversity at the sequence level and ...
  • G alpha (i) signalling events, organism-specific biosystem (from REACTOME)
    G alpha (i) signalling events, organism-specific biosystemThe classical signalling mechanism for G alpha (i) is inhibition of the cAMP dependent pathway through inhibition of adenylate cyclase. Decreased production of cAMP from ATP results in decreased act...
  • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
    GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
  • GPCR ligand binding, organism-specific biosystem (from REACTOME)
    GPCR ligand binding, organism-specific biosystemThere are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all...
  • GPCRs, Class A Rhodopsin-like, organism-specific biosystem (from WikiPathways)
    GPCRs, Class A Rhodopsin-like, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.gpcr.org/7tm/ (originally at http://www.cmbi.kun.nl/7tm/). The groupings are based on the GPCR phylogenetic tree available fr...
  • Hemostasis, organism-specific biosystem (from REACTOME)
    Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
  • Nucleotide-like (purinergic) receptors, organism-specific biosystem (from REACTOME)
    Nucleotide-like (purinergic) receptors, organism-specific biosystemPurinergic receptors (Burnstock G, 2006; Abbracchio MP et al, 2009) are a family of newly characterized plasma membrane molecules involved in several cellular functions such as vascular reactivity, a...
  • P2Y receptors, organism-specific biosystem (from REACTOME)
    P2Y receptors, organism-specific biosystemP2Y receptors are a family of purinergic receptors, G protein-coupled receptors stimulated by nucleotides such as ATP, ADP, UTP, UDP and UDP-glucose. To date, 12 P2Y receptors have been cloned in hum...
  • Platelet activation, organism-specific biosystem (from KEGG)
    Platelet activation, organism-specific biosystemPlatelets play a key and beneficial role for primary hemostasis on the disruption of the integrity of vessel wall. Platelet adhesion and activation at sites of vascular wall injury is initiated by ad...
  • Platelet activation, signaling and aggregation, organism-specific biosystem (from REACTOME)
    Platelet activation, signaling and aggregation, organism-specific biosystemPlatelet activation begins with the initial binding of adhesive ligands and of the excitatory platelet agonists (released or generated at the sites of vascular trauma) to cognate receptors on the pla...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signal amplification, organism-specific biosystem (from REACTOME)
    Signal amplification, organism-specific biosystemIn the initial response to injury, platelets adhere to damaged blood vessels, responding to the exposure of collagen from the vascular epithelium. Once adhered they degranulate, releasing stored seco...
  • Signaling by GPCR, organism-specific biosystem (from REACTOME)
    Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ADP receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
ADP receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
G protein-coupled adenosine receptor activity IEA
Inferred from Electronic Annotation
more info
 
G protein-coupled purinergic nucleotide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
guanyl-nucleotide exchange factor activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
G protein-coupled purinergic nucleotide receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
activation of phospholipase C activity TAS
Traceable Author Statement
more info
PubMed 
adenosine receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
calcium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
calcium-mediated signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
calcium-mediated signaling using extracellular calcium source ISS
Inferred from Sequence or Structural Similarity
more info
 
cell projection organization ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to ATP ISS
Inferred from Sequence or Structural Similarity
more info
 
cytosolic calcium signaling involved in initiation of cell movement in glial-mediated radial cell migration ISS
Inferred from Sequence or Structural Similarity
more info
 
hemostasis NAS
Non-traceable Author Statement
more info
PubMed 
lamellipodium assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
microglial cell migration TAS
Traceable Author Statement
more info
PubMed 
negative regulation of cell differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of norepinephrine secretion IEA
Inferred from Electronic Annotation
more info
 
phospholipase C-activating G protein-coupled receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
platelet aggregation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell adhesion mediated by integrin ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of chemotaxis ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of integrin activation by cell surface receptor linked signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of ion transport IEA
Inferred from Electronic Annotation
more info
 
positive regulation of microglial cell migration ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of microglial cell migration TAS
Traceable Author Statement
more info
PubMed 
positive regulation of phosphatidylinositol 3-kinase activity TAS
Traceable Author Statement
more info
PubMed 
positive regulation of protein kinase B signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of ruffle assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of ruffle assembly TAS
Traceable Author Statement
more info
PubMed 
potassium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
protein kinase B signaling IEA
Inferred from Electronic Annotation
more info
 
regulation of calcium ion transport IEA
Inferred from Electronic Annotation
more info
 
regulation of chemotaxis ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of chemotaxis TAS
Traceable Author Statement
more info
PubMed 
regulation of microglial cell migration ISS
Inferred from Sequence or Structural Similarity
more info
 
response to axon injury ISS
Inferred from Sequence or Structural Similarity
more info
 
substrate-dependent cell migration, cell extension ISS
Inferred from Sequence or Structural Similarity
more info
 
visual system development IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
basal plasma membrane IEA
Inferred from Electronic Annotation
more info
 
caveola IEA
Inferred from Electronic Annotation
more info
 
cell TAS
Traceable Author Statement
more info
PubMed 
cell body membrane IEA
Inferred from Electronic Annotation
more info
 
cell projection membrane IEA
Inferred from Electronic Annotation
more info
 
cell surface HDA PubMed 
external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
intrinsic component of membrane IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IEA
Inferred from Electronic Annotation
more info
 
plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
P2Y purinoceptor 12
Names
ADP-glucose receptor
G-protein coupled receptor SP1999
Gi-coupled ADP receptor HORK3
P2Y12 platelet ADP receptor
purinergic receptor P2RY12
purinergic receptor P2Y, G-protein coupled, 12
putative G-protein coupled receptor

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016019.1 RefSeqGene

    Range
    4945..52914
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_569

mRNA and Protein(s)

  1. NM_022788.5NP_073625.1  P2Y purinoceptor 12

    See identical proteins and their annotated locations for NP_073625.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AA810452, AF313449, AK292096, AW015793, AW976204, DB306976, DC313627
    Consensus CDS
    CCDS3159.1
    UniProtKB/Swiss-Prot
    Q9H244
    UniProtKB/TrEMBL
    A8K7T1
    Related
    ENSP00000307259.3, ENST00000302632.3
    Conserved Domains (1) summary
    cd15150
    Location:26309
    7tmA_P2Y12; P2Y purinoceptor 12, member of the class A family of seven-transmembrane G protein-coupled receptors
  2. NM_176876.3NP_795345.1  P2Y purinoceptor 12

    See identical proteins and their annotated locations for NP_795345.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AA810452, AF313449, AJ320495, AK292096, AW015793, AW976204, DA267276, DA343254, DB306976
    Consensus CDS
    CCDS3159.1
    UniProtKB/Swiss-Prot
    Q9H244
    UniProtKB/TrEMBL
    A8K7T1
    Conserved Domains (1) summary
    cd15150
    Location:26309
    7tmA_P2Y12; P2Y purinoceptor 12, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    151336843..151384812 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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