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RMND5A required for meiotic nuclear division 5 homolog A [ Homo sapiens (human) ]

Gene ID: 64795, updated on 7-Jun-2020

Summary

Official Symbol
RMND5Aprovided by HGNC
Official Full Name
required for meiotic nuclear division 5 homolog Aprovided by HGNC
Primary source
HGNC:HGNC:25850
See related
Ensembl:ENSG00000153561
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CTLH; GID2; RMD5; GID2A; p44CTLH
Expression
Ubiquitous expression in esophagus (RPKM 17.5), heart (RPKM 16.4) and 25 other tissues See more
Orthologs

Genomic context

See RMND5A in Genome Data Viewer
Location:
2p11.2
Exon count:
9
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (86720291..86778041)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (86947414..87005164)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene RNF103-CHMP3 readthrough Neighboring gene charged multivesicular body protein 3 Neighboring gene uncharacterized LOC105374845 Neighboring gene Sharpr-MPRA regulatory region 1991 Neighboring gene ring finger protein 103 Neighboring gene CD8A intronic regulatory region Neighboring gene uncharacterized LOC105374846 Neighboring gene CD8a molecule Neighboring gene CD8b molecule

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ12753, FLJ13910, FLJ21795, MGC78451

Gene Ontology Provided by GOA

Function Evidence Code Pubs
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin-protein transferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein polyubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
 
ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
GID complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin ligase complex ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
E3 ubiquitin-protein transferase RMND5A
Names
44-kD protein coding for CTLH motif
C-terminal to LisH motif, 44 kDa
GID complex subunit 2 homolog A
protein RMD5 homolog A
NP_073617.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022780.4NP_073617.1  E3 ubiquitin-protein transferase RMND5A

    See identical proteins and their annotated locations for NP_073617.1

    Status: VALIDATED

    Source sequence(s)
    AC064848, AK023972, BC012165, BC047668, BU620245
    Consensus CDS
    CCDS1991.1
    UniProtKB/Swiss-Prot
    Q9H871
    Related
    ENSP00000283632.4, ENST00000283632.5
    Conserved Domains (2) summary
    COG5109
    Location:17391
    COG5109; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    pfam10607
    Location:153297
    CLTH; CTLH/CRA C-terminal to LisH motif domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    86720291..86778041
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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