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DDX31 DEAD-box helicase 31 [ Homo sapiens (human) ]

Gene ID: 64794, updated on 4-Jun-2020

Summary

Official Symbol
DDX31provided by HGNC
Official Full Name
DEAD-box helicase 31provided by HGNC
Primary source
HGNC:HGNC:16715
See related
Ensembl:ENSG00000125485 MIM:616533
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PPP1R25
Summary
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a member of this family. The function of this member has not been determined. Alternative splicing of this gene generates multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2016]
Expression
Ubiquitous expression in thyroid (RPKM 4.3), ovary (RPKM 2.4) and 25 other tissues See more
Orthologs

Genomic context

See DDX31 in Genome Data Viewer
Location:
9q34.13
Exon count:
26
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (132592997..132670401, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (135468384..135545788, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene RNA, U5D small nuclear 2, pseudogene Neighboring gene cilia and flagella associated protein 77 Neighboring gene BarH like homeobox 1 Neighboring gene general transcription factor IIIC subunit 4 Neighboring gene Sharpr-MPRA regulatory region 7884 Neighboring gene adenylate kinase 8 Neighboring gene sperm acrosome associated 9

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ13633, FLJ14578, FLJ23349

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
RNA binding HDA PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
ribosome biogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ribosome biogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
probable ATP-dependent RNA helicase DDX31
Names
DEAD (Asp-Glu-Ala-Asp) box polypeptide 31
DEAD box protein 31
DEAD/DEXH helicase DDX31
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 31
G2 helicase
helicain
protein phosphatase 1, regulatory subunit 25
NP_001309269.1
NP_001309270.1
NP_001309271.1
NP_001309272.1
NP_001309273.1
NP_073616.6
NP_619526.1
XP_005272264.1
XP_006717299.1
XP_011517223.1
XP_011517224.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001322340.1NP_001309269.1  probable ATP-dependent RNA helicase DDX31 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AL160165, AL354735
    UniProtKB/Swiss-Prot
    Q9H8H2
    Conserved Domains (4) summary
    smart00487
    Location:254451
    DEXDc; DEAD-like helicases superfamily
    cd00268
    Location:232444
    DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
    pfam00271
    Location:501602
    Helicase_C; Helicase conserved C-terminal domain
    pfam13959
    Location:643681
    DUF4217; Domain of unknown function (DUF4217)
  2. NM_001322341.2NP_001309270.1  probable ATP-dependent RNA helicase DDX31 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AL160165, AL354735
    Conserved Domains (4) summary
    PRK01297
    Location:37570
    PRK01297; ATP-dependent RNA helicase RhlB; Provisional
    cd00268
    Location:136348
    DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
    pfam00271
    Location:405527
    Helicase_C; Helicase conserved C-terminal domain
    pfam13959
    Location:597658
    DUF4217; Domain of unknown function (DUF4217)
  3. NM_001322342.1NP_001309271.1  probable ATP-dependent RNA helicase DDX31 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AL160165, AL354735
    Conserved Domains (4) summary
    smart00487
    Location:77274
    DEXDc; DEAD-like helicases superfamily
    cd00268
    Location:55267
    DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
    pfam00271
    Location:324446
    Helicase_C; Helicase conserved C-terminal domain
    pfam13959
    Location:516577
    DUF4217; Domain of unknown function (DUF4217)
  4. NM_001322343.1NP_001309272.1  probable ATP-dependent RNA helicase DDX31 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AL160165, AL354735
    Conserved Domains (4) summary
    PRK01297
    Location:1537
    PRK01297; ATP-dependent RNA helicase RhlB; Provisional
    cd00268
    Location:103315
    DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
    pfam00271
    Location:372494
    Helicase_C; Helicase conserved C-terminal domain
    pfam13959
    Location:564625
    DUF4217; Domain of unknown function (DUF4217)
  5. NM_001322344.1NP_001309273.1  probable ATP-dependent RNA helicase DDX31 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AF335567, AL160165
    Consensus CDS
    CCDS83433.1
    UniProtKB/Swiss-Prot
    Q9H8H2
    Related
    ENSP00000479697.1, ENST00000480876.2
    Conserved Domains (2) summary
    COG0513
    Location:228305
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
    cl21455
    Location:232306
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  6. NM_022779.8NP_073616.6  probable ATP-dependent RNA helicase DDX31 isoform 1

    See identical proteins and their annotated locations for NP_073616.6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AF427339, AL354735
    Consensus CDS
    CCDS6951.1
    UniProtKB/Swiss-Prot
    Q9H8H2
    Related
    ENSP00000361232.3, ENST00000372159.7
    Conserved Domains (4) summary
    PRK01297
    Location:126666
    PRK01297; ATP-dependent RNA helicase RhlB; Provisional
    cd00079
    Location:481631
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    cd00268
    Location:232444
    DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
    pfam13959
    Location:693754
    DUF4217; Domain of unknown function (DUF4217)
  7. NM_138620.1NP_619526.1  probable ATP-dependent RNA helicase DDX31 isoform 2

    See identical proteins and their annotated locations for NP_619526.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has a shorter and alternate 3' region, as compared to variant 1. Since the first 3 nt of the alternate region is just an in-frame translation stop codon, this variant encodes a C-terminal truncated isoform (2) compared to isoform 1.
    Source sequence(s)
    AK027484
    Consensus CDS
    CCDS6952.1
    UniProtKB/Swiss-Prot
    Q9H8H2
    Related
    ENSP00000310539.1, ENST00000310532.6
    Conserved Domains (3) summary
    smart00487
    Location:254451
    DEXDc; DEAD-like helicases superfamily
    cd00268
    Location:232444
    DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
    pfam00271
    Location:501585
    Helicase_C; Helicase conserved C-terminal domain

RNA

  1. NR_136309.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL160165, AL354735

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    132592997..132670401 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006717236.4XP_006717299.1  probable ATP-dependent RNA helicase DDX31 isoform X3

    See identical proteins and their annotated locations for XP_006717299.1

    Conserved Domains (3) summary
    PRK01297
    Location:126640
    PRK01297; ATP-dependent RNA helicase RhlB; Provisional
    cd00268
    Location:232444
    DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
    pfam00271
    Location:501623
    Helicase_C; Helicase conserved C-terminal domain
  2. XM_005272207.4XP_005272264.1  probable ATP-dependent RNA helicase DDX31 isoform X2

    Conserved Domains (4) summary
    PRK01297
    Location:37570
    PRK01297; ATP-dependent RNA helicase RhlB; Provisional
    cd00268
    Location:136348
    DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
    pfam00271
    Location:405527
    Helicase_C; Helicase conserved C-terminal domain
    pfam13959
    Location:597658
    DUF4217; Domain of unknown function (DUF4217)
  3. XM_011518922.3XP_011517224.1  probable ATP-dependent RNA helicase DDX31 isoform X3

    See identical proteins and their annotated locations for XP_011517224.1

    Conserved Domains (3) summary
    PRK01297
    Location:126640
    PRK01297; ATP-dependent RNA helicase RhlB; Provisional
    cd00268
    Location:232444
    DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
    pfam00271
    Location:501623
    Helicase_C; Helicase conserved C-terminal domain
  4. XM_011518921.3XP_011517223.1  probable ATP-dependent RNA helicase DDX31 isoform X1

    Conserved Domains (4) summary
    PRK01297
    Location:126666
    PRK01297; ATP-dependent RNA helicase RhlB; Provisional
    cd00079
    Location:481631
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    cd00268
    Location:232444
    DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
    pfam13959
    Location:693754
    DUF4217; Domain of unknown function (DUF4217)

RNA

  1. XR_001746366.2 RNA Sequence

  2. XR_246600.5 RNA Sequence

  3. XR_929836.3 RNA Sequence

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