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IFT22 intraflagellar transport 22 [ Homo sapiens (human) ]

Gene ID: 64792, updated on 8-Jul-2019

Summary

Official Symbol
IFT22provided by HGNC
Official Full Name
intraflagellar transport 22provided by HGNC
Primary source
HGNC:HGNC:21895
See related
Ensembl:ENSG00000128581
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RABL5
Expression
Broad expression in testis (RPKM 22.2), thyroid (RPKM 11.1) and 21 other tissues See more
Orthologs

Genomic context

See IFT22 in Genome Data Viewer
Location:
7q22.1
Exon count:
6
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (101310914..101321823, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (100956648..100965093, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene AZGP1 pseudogene 2 Neighboring gene uncharacterized LOC101927746 Neighboring gene lncRNA p53 regulated and ESC associated 1 Neighboring gene collagen type XXVI alpha 1 chain Neighboring gene uncharacterized LOC105379743 Neighboring gene long intergenic non-protein coding RNA 1007

Genomic regions, transcripts, and products

Pathways from BioSystems

  • Cilium Assembly, organism-specific biosystem (from REACTOME)
    Cilium Assembly, organism-specific biosystemCilia are membrane covered organelles that extend from the surface of eukaryotic cells. Cilia may be motile, such as respiratory cilia) or non-motile (such as the primary cilium) and are distinguishe...
  • Intraflagellar transport, organism-specific biosystem (from REACTOME)
    Intraflagellar transport, organism-specific biosystemIntraflagellar transport (IFT) is a motor-based process that controls the anterograde and retrograde transport of large protein complexes, ciliary cargo and structural components along the ciliary ax...
  • Organelle biogenesis and maintenance, organism-specific biosystem (from REACTOME)
    Organelle biogenesis and maintenance, organism-specific biosystemThis module describes the biogenesis of organelles. Organelles are subcellular structures of distinctive morphology and function. The organelles of human cells include: mitochondria, endoplasmic reti...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ13225, FLJ14117, DKFZp761N0823

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTP binding IEA
Inferred from Electronic Annotation
more info
 
GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
Rab protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intraciliary transport involved in cilium assembly TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
centrosome IEA
Inferred from Electronic Annotation
more info
 
ciliary tip TAS
Traceable Author Statement
more info
 
cilium TAS
Traceable Author Statement
more info
 
intraciliary transport particle B ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
intraflagellar transport protein 22 homolog
Names
RAB, member RAS oncogene family-like 5
RAB, member of RAS oncogene family-like 5
intraflagellar transport 22 homolog
rab-like protein 5

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130820.3NP_001124292.1  intraflagellar transport protein 22 homolog isoform b

    See identical proteins and their annotated locations for NP_001124292.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. It encodes isoform b, which is shorter than isoform a.
    Source sequence(s)
    AC006329, BC004522, CA841889, DA709553
    Consensus CDS
    CCDS47670.1
    UniProtKB/Swiss-Prot
    Q9H7X7
    Related
    ENSP00000390770.2, ENST00000437644.2
    Conserved Domains (1) summary
    cl21455
    Location:591
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  2. NM_001130821.3NP_001124293.1  intraflagellar transport protein 22 homolog isoform c

    See identical proteins and their annotated locations for NP_001124293.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. Variants 3 through 6 encode the same isoform (c), which is shorter at the N-terminus, compared to isoform a.
    Source sequence(s)
    AC006329, BC004522, CA841889, DA709553, DN993868
    Consensus CDS
    CCDS47671.1
    UniProtKB/Swiss-Prot
    Q9H7X7
    UniProtKB/TrEMBL
    A0A024QYT8
  3. NM_001130822.3NP_001124294.1  intraflagellar transport protein 22 homolog isoform c

    See identical proteins and their annotated locations for NP_001124294.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. Variants 3 through 6 encode the same isoform (c), which is shorter at the N-terminus, compared to isoform a.
    Source sequence(s)
    AC006329, AK298888, CA841889, DA709553
    Consensus CDS
    CCDS47671.1
    UniProtKB/Swiss-Prot
    Q9H7X7
    UniProtKB/TrEMBL
    A0A024QYT8
    Related
    ENSP00000429648.1, ENST00000498704.6
  4. NM_001287525.2NP_001274454.1  intraflagellar transport protein 22 homolog isoform c

    See identical proteins and their annotated locations for NP_001274454.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. Variants 3 through 6 encode the same isoform (c), which is shorter at the N-terminus, compared to isoform a.
    Source sequence(s)
    AC006329, AU133515, BC009823, CA841889, DA709553
    Consensus CDS
    CCDS47671.1
    UniProtKB/Swiss-Prot
    Q9H7X7
    UniProtKB/TrEMBL
    A0A024QYT8
    Related
    ENSP00000429202.1, ENST00000517481.5
  5. NM_001287526.1NP_001274455.1  intraflagellar transport protein 22 homolog isoform c

    See identical proteins and their annotated locations for NP_001274455.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. Variants 3 through 6 encode the same isoform (c), which is shorter at the N-terminus, compared to isoform a.
    Source sequence(s)
    AC006329, CA841889, DA700693, DA709553
    Consensus CDS
    CCDS47671.1
    UniProtKB/Swiss-Prot
    Q9H7X7
    UniProtKB/TrEMBL
    A0A024QYT8
    Related
    ENSP00000478948.1, ENST00000621899.4
  6. NM_022777.4NP_073614.1  intraflagellar transport protein 22 homolog isoform a

    See identical proteins and their annotated locations for NP_073614.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AC006329, BC009823, CA841889, DA709553
    Consensus CDS
    CCDS5719.1
    UniProtKB/Swiss-Prot
    Q9H7X7
    UniProtKB/TrEMBL
    A0A024QYV3
    Related
    ENSP00000320359.4, ENST00000315322.9
    Conserved Domains (1) summary
    COG1100
    Location:1104
    Gem1; GTPase SAR1 family domain [General function prediction only]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    101310914..101321823 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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