Format

Send to:

Choose Destination

EXO5 exonuclease 5 [ Homo sapiens (human) ]

Gene ID: 64789, updated on 23-Nov-2021

Summary

Official Symbol
EXO5provided by HGNC
Official Full Name
exonuclease 5provided by HGNC
Primary source
HGNC:HGNC:26115
See related
Ensembl:ENSG00000164002 MIM:618601
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DEM1; Exo V; hExo5; C1orf176
Summary
The protein encoded by this gene is a single-stranded DNA (ssDNA)-specific exonuclease that can slide along the DNA before cutting it. However, human replication protein A binds ssDNA and restricts sliding of the encoded protein, providing a 5'-directionality to the enzyme. This protein localizes to nuclear repair loci after DNA damage. [provided by RefSeq, Nov 2016]
Expression
Ubiquitous expression in lymph node (RPKM 2.5), appendix (RPKM 2.1) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See EXO5 in Genome Data Viewer
Location:
1p34.2
Exon count:
4
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (40508741..40516050)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (40974439..40981710)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ZFP69 zinc finger protein B Neighboring gene ZFP69 zinc finger protein Neighboring gene EXO5 divergent transcript Neighboring gene Sharpr-MPRA regulatory region 98 Neighboring gene zinc finger protein 684 Neighboring gene eukaryotic translation initiation factor 2 subunit gamma pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Copy number response

Description
Copy number response
Triplosensitivity

No evidence available (Last evaluated 2021-02-02)

ClinGen Genome Curation Page
Haploinsufficency

Dosage sensitivity unlikely (Last evaluated 2021-02-02)

ClinGen Genome Curation PagePubMed

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ11445, FLJ13183, FLJ21144

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 4 iron, 4 sulfur cluster binding IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables single-stranded DNA 3'-5' exodeoxyribonuclease activity TAS
Traceable Author Statement
more info
PubMed 
enables single-stranded DNA 5'-3' exodeoxyribonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables single-stranded DNA 5'-3' exodeoxyribonuclease activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in interstrand cross-link repair IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in interstrand cross-link repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in nucleic acid phosphodiester bond hydrolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
exonuclease V
Names
defects in morphology 1 homolog
defects in morphology protein 1 homolog
probable exonuclease V

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001346946.2NP_001333875.1  exonuclease V

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All variants encode the same protein.
    Source sequence(s)
    AK024797, BP376962, CA419097, DA705199
    Consensus CDS
    CCDS453.1
    UniProtKB/Swiss-Prot
    Q9H790
  2. NM_001346947.2NP_001333876.1  exonuclease V

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All variants encode the same protein.
    Source sequence(s)
    AK024797, CA419097, DA070927
    Consensus CDS
    CCDS453.1
    UniProtKB/Swiss-Prot
    Q9H790
    Related
    ENSP00000508270.1, ENST00000682383.1
  3. NM_001346948.2NP_001333877.1  exonuclease V

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. All variants encode the same protein.
    Source sequence(s)
    AK024797, CA419097, DA630059
    Consensus CDS
    CCDS453.1
    UniProtKB/Swiss-Prot
    Q9H790
    Related
    ENSP00000391240.2, ENST00000418186.2
  4. NM_001346949.2NP_001333878.1  exonuclease V

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. All variants encode the same protein.
    Source sequence(s)
    AL603839, BC021969, CA419097, DA705199
    Consensus CDS
    CCDS453.1
    UniProtKB/Swiss-Prot
    Q9H790
    Related
    ENSP00000351328.2, ENST00000358527.6
  5. NM_001346950.2NP_001333879.1  exonuclease V

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. All variants encode the same protein.
    Source sequence(s)
    AK024797, AL603839, CA419097, DA270855, DA705199
    Consensus CDS
    CCDS453.1
    UniProtKB/Swiss-Prot
    Q9H790
    Related
    ENSP00000416857.2, ENST00000432259.6
  6. NM_001346951.2NP_001333880.1  exonuclease V

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 1. All variants encode the same protein.
    Source sequence(s)
    AL603839
    Consensus CDS
    CCDS453.1
    UniProtKB/Swiss-Prot
    Q9H790
    Related
    ENSP00000409715.2, ENST00000443729.6
  7. NM_001346952.2NP_001333881.1  exonuclease V

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR compared to variant 1. All variants encode the same protein.
    Source sequence(s)
    AL603839
    Consensus CDS
    CCDS453.1
    UniProtKB/Swiss-Prot
    Q9H790
  8. NM_001346953.2NP_001333882.1  exonuclease V

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) differs in the 5' UTR compared to variant 1. All variants encode the same protein.
    Source sequence(s)
    AL603839
    Consensus CDS
    CCDS453.1
    UniProtKB/Swiss-Prot
    Q9H790
    Related
    ENSP00000413565.2, ENST00000415550.6
  9. NM_001346954.2NP_001333883.1  exonuclease V

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) differs in the 5' UTR compared to variant 1. All variants encode the same protein.
    Source sequence(s)
    AL603839
    Consensus CDS
    CCDS453.1
    UniProtKB/Swiss-Prot
    Q9H790
    Related
    ENSP00000398437.2, ENST00000420209.2
  10. NM_001346955.2NP_001333884.1  exonuclease V

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11) differs in the 5' UTR compared to variant 1. All variants encode the same protein.
    Source sequence(s)
    AL603839
    Consensus CDS
    CCDS453.1
    UniProtKB/Swiss-Prot
    Q9H790
  11. NM_001346956.2NP_001333885.1  exonuclease V

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12) differs in the 5' UTR compared to variant 1. All variants encode the same protein.
    Source sequence(s)
    AL603839
    Consensus CDS
    CCDS453.1
    UniProtKB/Swiss-Prot
    Q9H790
    Related
    ENSP00000392115.2, ENST00000419161.2
  12. NM_022774.3NP_073611.1  exonuclease V

    See identical proteins and their annotated locations for NP_073611.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All variants encode the same protein.
    Source sequence(s)
    AK024797, CA419097
    Consensus CDS
    CCDS453.1
    UniProtKB/Swiss-Prot
    Q9H790
    Related
    ENSP00000296380.4, ENST00000296380.9
    Conserved Domains (1) summary
    pfam09810
    Location:72355
    Exo5; Exonuclease V - a 5' deoxyribonuclease

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    40508741..40516050
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017002099.2XP_016857588.1  exonuclease V isoform X1

    UniProtKB/Swiss-Prot
    Q9H790
    Conserved Domains (1) summary
    pfam09810
    Location:72355
    Exo5; Exonuclease V - a 5' deoxyribonuclease
  2. XM_017002102.2XP_016857591.1  exonuclease V isoform X1

    UniProtKB/Swiss-Prot
    Q9H790
    Related
    ENSP00000361788.1, ENST00000372703.1
    Conserved Domains (1) summary
    pfam09810
    Location:72355
    Exo5; Exonuclease V - a 5' deoxyribonuclease
Support Center