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LMF1 lipase maturation factor 1 [ Homo sapiens (human) ]

Gene ID: 64788, updated on 24-Nov-2020

Summary

Official Symbol
LMF1provided by HGNC
Official Full Name
lipase maturation factor 1provided by HGNC
Primary source
HGNC:HGNC:14154
See related
Ensembl:ENSG00000103227 MIM:611761
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
JFP11; TMEM112; C16orf26; HMFN1876; TMEM112A
Expression
Broad expression in brain (RPKM 6.7), salivary gland (RPKM 2.6) and 25 other tissues See more
Orthologs

Genomic context

See LMF1 in Genome Data Viewer
Location:
16p13.3
Exon count:
15
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (853634..981613, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (903634..1031318, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene chromosome transmission fidelity factor 18 Neighboring gene G protein subunit gamma 13 Neighboring gene proline rich 25 Neighboring gene uncharacterized LOC107984876 Neighboring gene LMF1 antisense RNA 1 Neighboring gene uncharacterized LOC107984898 Neighboring gene cytoplasmic endogenous regulator of oxidative phosphorylation 1 Neighboring gene SRY-box transcription factor 8

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association analysis of red blood cell traits in African Americans: the COGENT Network.
GeneReviews: Not available
Lipase deficiency, combined
MedGen: C1855498 OMIM: 246650 GeneReviews: Not available
Compare labs

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: CEROX1

Homology

Clone Names

  • FLJ12681, FLJ22302

Gene Ontology Provided by GOA

Process Evidence Code Pubs
chylomicron remnant clearance IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum to Golgi vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
 
positive regulation of lipoprotein lipase activity IEA
Inferred from Electronic Annotation
more info
 
protein glycosylation in Golgi IEA
Inferred from Electronic Annotation
more info
 
protein maturation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein secretion IEA
Inferred from Electronic Annotation
more info
 
regulation of cholesterol metabolic process IEA
Inferred from Electronic Annotation
more info
 
regulation of lipoprotein lipase activity TAS
Traceable Author Statement
more info
 
regulation of triglyceride metabolic process IEA
Inferred from Electronic Annotation
more info
 
triglyceride metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
lipase maturation factor 1
Names
transmembrane protein 112

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_021286.2 RefSeqGene

    Range
    15617..132982
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001352017.2NP_001338946.1  lipase maturation factor 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC009041, AK093050, AK125201, AK225065, CA427159
    Consensus CDS
    CCDS86488.1
    Conserved Domains (1) summary
    pfam06762
    Location:1330
    LMF1; Lipase maturation factor
  2. NM_001352018.2NP_001338947.1  lipase maturation factor 1 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC009041, AL008727, AL031008, AL031716, CA427159, Z93041
    Conserved Domains (1) summary
    pfam06762
    Location:41414
    LMF1; Lipase maturation factor
  3. NM_001352019.2NP_001338948.1  lipase maturation factor 1 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC009041, AL008727, AL031008, AL031716, CA427159, Z93041
    Conserved Domains (1) summary
    pfam06762
    Location:65438
    LMF1; Lipase maturation factor
  4. NM_001352020.1NP_001338949.1  lipase maturation factor 1 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC009041, AL008727, AL031008, AL031716, CA427159, Z93041
    Conserved Domains (1) summary
    pfam06762
    Location:174465
    LMF1; Lipase maturation factor
  5. NM_001352021.2NP_001338950.1  lipase maturation factor 1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC009041, AL008727, AL031008, AL031716, CA427159, Z93041
    Consensus CDS
    CCDS86488.1
    Related
    ENSP00000458135.1, ENST00000568897.5
    Conserved Domains (1) summary
    pfam06762
    Location:1330
    LMF1; Lipase maturation factor
  6. NM_022773.4NP_073610.2  lipase maturation factor 1 isoform 1

    See identical proteins and their annotated locations for NP_073610.2

    Status: REVIEWED

    Source sequence(s)
    AC009041, AL008727, AL031008, AL031716, Z93041
    Consensus CDS
    CCDS45373.1
    UniProtKB/Swiss-Prot
    Q96S06
    Related
    ENSP00000262301.11, ENST00000262301.15
    Conserved Domains (1) summary
    pfam06762
    Location:174547
    LMF1; Lipase maturation factor

RNA

  1. NR_147885.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC009041, AL008727, AL031008, AL031716, CA427159, Z93041

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    853634..981613 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NR_033646.1: Suppressed sequence

    Description
    NR_033646.1: This RefSeq was removed because currently there is insufficient support for the transcript.
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