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GINS3 GINS complex subunit 3 [ Homo sapiens (human) ]

Gene ID: 64785, updated on 7-Aug-2021

Summary

Official Symbol
GINS3provided by HGNC
Official Full Name
GINS complex subunit 3provided by HGNC
Primary source
HGNC:HGNC:25851
See related
Ensembl:ENSG00000181938 MIM:610610
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PSF3
Summary
This gene encodes a protein subunit of the GINS heterotetrameric complex, which is essential for the initiation of DNA replication and replisome progression in eukaryotes. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in lymph node (RPKM 4.0), testis (RPKM 3.9) and 25 other tissues See more
Orthologs
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Genomic context

See GINS3 in Genome Data Viewer
Location:
16q21
Exon count:
4
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (58392471..58406147)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (58426375..58440051)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 269, pseudogene Neighboring gene RNA, U6 small nuclear 1110, pseudogene Neighboring gene long intergenic non-protein coding RNA 2137 Neighboring gene Sharpr-MPRA regulatory region 12894 Neighboring gene NDRG family member 4 Neighboring gene RNA, U6 small nuclear 103, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Common variants at ten loci influence QT interval duration in the QTGEN Study.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ13912

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in mitotic DNA replication initiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
part_of CMG complex ISS
Inferred from Sequence or Structural Similarity
more info
 
part_of GINS complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
DNA replication complex GINS protein PSF3
Names
GINS complex subunit 3 (Psf3 homolog)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001126129.2NP_001119601.1  DNA replication complex GINS protein PSF3 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AC009118, BC005879, BP374281, DA550725
    Consensus CDS
    CCDS45498.1
    UniProtKB/Swiss-Prot
    Q9BRX5
    UniProtKB/TrEMBL
    A0A0S2Z5P2
    Related
    ENSP00000401018.2, ENST00000426538.6
    Conserved Domains (1) summary
    cd11713
    Location:122231
    GINS_A_psf3; Alpha-helical domain of GINS complex protein Psf3 (partner of Sld5 3)
  2. NM_001126130.2NP_001119602.1  DNA replication complex GINS protein PSF3 isoform c

    See identical proteins and their annotated locations for NP_001119602.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks two alternate in-frame exons, compared to variant 1, resulting in a shorter protein (isoform c), compared to isoform a.
    Source sequence(s)
    AC009118, BC005879, DA550725
    Consensus CDS
    CCDS45499.1
    UniProtKB/Swiss-Prot
    Q9BRX5
    UniProtKB/TrEMBL
    A0A0S2Z5L4
    Related
    ENSP00000327449.7, ENST00000328514.11
    Conserved Domains (2) summary
    cd11713
    Location:42114
    GINS_A_psf3; Alpha-helical domain of GINS complex protein Psf3 (partner of Sld5 3)
    cl41778
    Location:1962
    GINS_B; beta-strand (B) domain of GINS complex proteins: Sld5, Psf1, Psf2, Psf3, Gins51 and Gins23
  3. NM_022770.4NP_073607.2  DNA replication complex GINS protein PSF3 isoform b

    See identical proteins and their annotated locations for NP_073607.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1, resulting in a shorter protein (isoform b), compared to isoform a.
    Source sequence(s)
    AC009118, BC005879, DA550725
    Consensus CDS
    CCDS10796.1
    UniProtKB/Swiss-Prot
    Q9BRX5
    UniProtKB/TrEMBL
    A0A0S2Z5L0
    Related
    ENSP00000318196.6, ENST00000318129.6
    Conserved Domains (2) summary
    cd11713
    Location:83192
    GINS_A_psf3; Alpha-helical domain of GINS complex protein Psf3 (partner of Sld5 3)
    cd21693
    Location:1989
    GINS_B_Psf3; beta-strand (B) domain of GINS complex protein Psf3

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    58392471..58406147
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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