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CRTC3 CREB regulated transcription coactivator 3 [ Homo sapiens (human) ]

Gene ID: 64784, updated on 21-Dec-2019

Summary

Official Symbol
CRTC3provided by HGNC
Official Full Name
CREB regulated transcription coactivator 3provided by HGNC
Primary source
HGNC:HGNC:26148
See related
Ensembl:ENSG00000140577 MIM:608986
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TORC3; TORC-3
Summary
This gene is a member of the CREB regulated transcription coactivator gene family. This family regulates CREB-dependent gene transcription in a phosphorylation-independent manner and may be selective for cAMP-responsive genes. The protein encoded by this gene may induce mitochondrial biogenesis and attenuate catecholamine signaling in adipose tissue. A translocation event between this gene and Notch coactivator mastermind-like gene 2, which results in a fusion protein, has been reported in mucoepidermoid carcinomas. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]
Expression
Ubiquitous expression in ovary (RPKM 20.6), fat (RPKM 11.8) and 25 other tissues See more
Orthologs

Genomic context

See CRTC3 in Genome Data Viewer
Location:
15q26.1
Exon count:
17
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (90529915..90645345)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (91073118..91188577)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene NADH:ubiquinone oxidoreductase subunit A3 pseudogene 4 Neighboring gene IQ motif containing GTPase activating protein 1 Neighboring gene uncharacterized LOC112268163 Neighboring gene CRTC3 antisense RNA 1 Neighboring gene heat shock protein family E (Hsp10) member 1 pseudogene 3 Neighboring gene long intergenic non-protein coding RNA 1585 Neighboring gene BLM RecQ like helicase

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
NHGRI GWA Catalog
Whole genome association scan for genetic polymorphisms influencing information processing speed.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of CREB regulated transcription coactivator 3 (CRTC3) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ21868

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cAMP response element binding protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
energy homeostasis IEA
Inferred from Electronic Annotation
more info
 
macrophage activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cAMP-mediated signaling IEA
Inferred from Electronic Annotation
more info
 
negative regulation of lipid catabolic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of CREB transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein homotetramerization IEA
Inferred from Electronic Annotation
more info
 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
CREB-regulated transcription coactivator 3
Names
transducer of regulated CREB protein 3
transducer of regulated cAMP response element-binding protein (CREB) 3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047180.1 RefSeqGene

    Range
    5038..120460
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001042574.3NP_001036039.1  CREB-regulated transcription coactivator 3 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' terminal exon compared to variant 1. It encodes isoform b which is shorter than isoform a.
    Source sequence(s)
    AI969212, AK025521, AK074170, AL360259, AY360173, BP238198, BP365179, DB288138, HY057135, HY109267
    Consensus CDS
    CCDS45348.1
    UniProtKB/Swiss-Prot
    Q6UUV7
    UniProtKB/TrEMBL
    Q8TEF4
    Related
    ENSP00000416573.2, ENST00000420329.6
    Conserved Domains (3) summary
    pfam12884
    Location:1164
    TORC_N; Transducer of regulated CREB activity, N terminus
    pfam12885
    Location:159319
    TORC_M; Transducer of regulated CREB activity middle domain
    pfam12886
    Location:545618
    TORC_C; Transducer of regulated CREB activity, C terminus
  2. NM_022769.5NP_073606.3  CREB-regulated transcription coactivator 3 isoform a

    See identical proteins and their annotated locations for NP_073606.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AC021422, AI969212, AK074170, AL360259, AY360173, BP238198, BP365179, CN298837, DB288138, HY057135, HY109267
    Consensus CDS
    CCDS32331.1
    UniProtKB/Swiss-Prot
    Q6UUV7
    UniProtKB/TrEMBL
    Q8TEF4
    Related
    ENSP00000268184.6, ENST00000268184.11
    Conserved Domains (3) summary
    pfam12884
    Location:1164
    TORC_N; Transducer of regulated CREB activity, N terminus
    pfam12885
    Location:159319
    TORC_M; Transducer of regulated CREB activity middle domain
    pfam12886
    Location:545619
    TORC_C; Transducer of regulated CREB activity, C terminus

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    90529915..90645345
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005254968.2XP_005255025.1  CREB-regulated transcription coactivator 3 isoform X1

    Conserved Domains (3) summary
    pfam12884
    Location:1164
    TORC_N; Transducer of regulated CREB activity, N terminus
    pfam12885
    Location:159318
    TORC_M; Transducer of regulated CREB activity middle domain
    pfam12886
    Location:544618
    TORC_C; Transducer of regulated CREB activity, C terminus
  2. XM_011521906.2XP_011520208.1  CREB-regulated transcription coactivator 3 isoform X2

    Conserved Domains (3) summary
    pfam12884
    Location:1159
    TORC_N; Transducer of regulated CREB activity, N terminus
    pfam12885
    Location:126286
    TORC_M; Transducer of regulated CREB activity middle domain
    pfam12886
    Location:512586
    TORC_C; Transducer of regulated CREB activity, C terminus
  3. XM_024450019.1XP_024305787.1  CREB-regulated transcription coactivator 3 isoform X3

    Conserved Domains (3) summary
    pfam12885
    Location:6128
    TORC_M; Transducer of regulated CREB activity middle domain
    pfam12886
    Location:354428
    TORC_C; Transducer of regulated CREB activity, C terminus
    cl27975
    Location:155346
    EBV-NA3; Epstein-Barr virus nuclear antigen 3 (EBNA-3)
  4. XM_024450018.1XP_024305786.1  CREB-regulated transcription coactivator 3 isoform X3

    Conserved Domains (3) summary
    pfam12885
    Location:6128
    TORC_M; Transducer of regulated CREB activity middle domain
    pfam12886
    Location:354428
    TORC_C; Transducer of regulated CREB activity, C terminus
    cl27975
    Location:155346
    EBV-NA3; Epstein-Barr virus nuclear antigen 3 (EBNA-3)
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