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RBM15 RNA binding motif protein 15 [ Homo sapiens (human) ]

Gene ID: 64783, updated on 13-Mar-2020

Summary

Official Symbol
RBM15provided by HGNC
Official Full Name
RNA binding motif protein 15provided by HGNC
Primary source
HGNC:HGNC:14959
See related
Ensembl:ENSG00000162775 MIM:606077
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OTT; OTT1; SPEN
Summary
Members of the SPEN (Split-end) family of proteins, including RBM15, have repressor function in several signaling pathways and may bind to RNA through interaction with spliceosome components (Hiriart et al., 2005 [PubMed 16129689]).[supplied by OMIM, Feb 2009]
Expression
Broad expression in bone marrow (RPKM 6.3), testis (RPKM 2.8) and 24 other tissues See more
Orthologs

Genomic context

See RBM15 in Genome Data Viewer
Location:
1p13.3
Exon count:
3
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (110339323..110346681)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (110881945..110889303)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene potassium voltage-gated channel subfamily C member 4 Neighboring gene RBM15 antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 11911 Neighboring gene solute carrier family 16 member 4 Neighboring gene LAMTOR5 antisense RNA 1 Neighboring gene late endosomal/lysosomal adaptor, MAPK and MTOR activator 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag NXF1 upregulates the RBM15-mediated Gag expression from pNLgag-RTE, suggesting cooperation between RBM15 and NXF1 PubMed
Rev rev HIV-1 Rev interacting protein, RNA binding motif protein 15 (RBM15), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells. The interaction of Rev with RBM15 is increased by RRE PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ12479, FLJ21943, MGC119584

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
mRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
RNA methylation IDA
Inferred from Direct Assay
more info
PubMed 
branching involved in blood vessel morphogenesis IEA
Inferred from Electronic Annotation
more info
 
dosage compensation by inactivation of X chromosome IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of myeloid cell differentiation IEA
Inferred from Electronic Annotation
more info
 
NOT negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
placenta blood vessel development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription of Notch receptor target IEA
Inferred from Electronic Annotation
more info
 
regulation of alternative mRNA splicing, via spliceosome IDA
Inferred from Direct Assay
more info
PubMed 
regulation of megakaryocyte differentiation IDA
Inferred from Direct Assay
more info
PubMed 
spleen development IEA
Inferred from Electronic Annotation
more info
 
thrombopoietin-mediated signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
ventricular septum morphogenesis IEA
Inferred from Electronic Annotation
more info
 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
RNA N6-methyladenosine methyltransferase complex IDA
Inferred from Direct Assay
more info
PubMed 
nuclear membrane IEA
Inferred from Electronic Annotation
more info
 
nuclear speck IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
RNA-binding protein 15
Names
one twenty two protein
one twenty-two
one-twenty two protein 1
putative RNA-binding protein 15

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001201545.1NP_001188474.1  RNA-binding protein 15 isoform 2

    See identical proteins and their annotated locations for NP_001188474.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 3' coding region, compared to variant 1. The resulting protein (isoform 2) has a shorter and distinct C-terminus when it is compared to isoform 1.
    Source sequence(s)
    AF368062, AI863760, BC006397, BC098140
    Consensus CDS
    CCDS59198.1
    UniProtKB/Swiss-Prot
    Q96T37
    Related
    ENSP00000473552.3, ENST00000487146.8
    Conserved Domains (5) summary
    cd12553
    Location:169251
    RRM1_RBM15; RNA recognition motif 1 in vertebrate RNA binding motif protein 15 (RBM15)
    cd12555
    Location:367453
    RRM2_RBM15; RNA recognition motif 2 in vertebrate RNA binding motif protein 15 (RBM15)
    cd12557
    Location:456528
    RRM3_RBM15; RNA recognition motif 3 in vertebrate RNA binding motif protein 15 (RBM15)
    pfam07744
    Location:781954
    SPOC; SPOC domain
    cl25887
    Location:624736
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
  2. NM_022768.4NP_073605.4  RNA-binding protein 15 isoform 1

    See identical proteins and their annotated locations for NP_073605.4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer protein (isoform 1).
    Source sequence(s)
    AW173262, BC042587, BC047479, BC062316
    Consensus CDS
    CCDS822.1
    UniProtKB/Swiss-Prot
    Q96T37
    Related
    ENSP00000483133.1, ENST00000618772.4
    Conserved Domains (5) summary
    cd12553
    Location:169251
    RRM1_RBM15; RNA recognition motif 1 in vertebrate RNA binding motif protein 15 (RBM15)
    cd12555
    Location:367453
    RRM2_RBM15; RNA recognition motif 2 in vertebrate RNA binding motif protein 15 (RBM15)
    cd12557
    Location:456528
    RRM3_RBM15; RNA recognition motif 3 in vertebrate RNA binding motif protein 15 (RBM15)
    pfam07744
    Location:781954
    SPOC; SPOC domain
    cl25887
    Location:624736
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    110339323..110346681
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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