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MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1 [ Homo sapiens (human) ]

Gene ID: 64780, updated on 19-Jan-2019

Summary

Official Symbol
MICAL1provided by HGNC
Official Full Name
microtubule associated monooxygenase, calponin and LIM domain containing 1provided by HGNC
Primary source
HGNC:HGNC:20619
See related
Ensembl:ENSG00000135596 MIM:607129
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MICAL; NICAL; MICAL-1
Summary
This gene encodes an enzyme that oxidizes methionine residues on actin, thereby promoting depolymerization of actin filaments. This protein interacts with and regulates signalling by NEDD9/CAS-L (neural precursor cell expressed, developmentally down-regulated 9). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]
Expression
Ubiquitous expression in bone marrow (RPKM 31.4), lymph node (RPKM 25.8) and 23 other tissues See more
Orthologs

Genomic context

See MICAL1 in Genome Data Viewer
Location:
6q21
Exon count:
26
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 6 NC_000006.12 (109444062..109465968, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (109765265..109787171, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene CD164 molecule Neighboring gene peptidylprolyl isomerase like 6 Neighboring gene uncharacterized LOC105377935 Neighboring gene sphingomyelin phosphodiesterase 2 Neighboring gene zinc finger and BTB domain containing 24 Neighboring gene adenylate kinase 9 Neighboring gene FIG4 phosphoinositide 5-phosphatase

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Epilepsy, lateral temporal lobe, autosomal dominant not available

NHGRI GWAS Catalog

Description
Hundreds of variants clustered in genomic loci and biological pathways affect human height.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Clone Names

  • FLJ11937, FLJ21739, DKFZp434B1517

Gene Ontology Provided by GOA

Function Evidence Code Pubs
FAD binding IDA
Inferred from Direct Assay
more info
PubMed 
NAD(P)H oxidase activity IDA
Inferred from Direct Assay
more info
PubMed 
Rab GTPase binding IEA
Inferred from Electronic Annotation
more info
 
SH3 domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
actin binding IDA
Inferred from Direct Assay
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
monooxygenase activity TAS
Traceable Author Statement
more info
 
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
actin filament depolymerization IDA
Inferred from Direct Assay
more info
PubMed 
blood coagulation TAS
Traceable Author Statement
more info
 
cytoskeleton organization NAS
Non-traceable Author Statement
more info
PubMed 
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
oxidation-reduction process IDA
Inferred from Direct Assay
more info
PubMed 
regulation of regulated secretory pathway IEA
Inferred from Electronic Annotation
more info
 
signal transduction NAS
Non-traceable Author Statement
more info
PubMed 
sulfur oxidation ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
hippocampal mossy fiber expansion IEA
Inferred from Electronic Annotation
more info
 
intercellular bridge IDA
Inferred from Direct Assay
more info
PubMed 
intermediate filament NAS
Non-traceable Author Statement
more info
PubMed 
midbody IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
[F-actin]-monooxygenase MICAL1
Names
NEDD9-interacting protein with calponin homology and LIM domains
[F-actin]-methionine sulfoxide oxidase MICAL1
molecule interacting with CasL protein 1
protein-methionine sulfoxide oxidase MICAL1
NP_001152763.1
NP_001273542.1
NP_073602.3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_042833.1 RefSeqGene

    Range
    5001..26907
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001159291.1NP_001152763.1  [F-actin]-monooxygenase MICAL1 isoform 2

    See identical proteins and their annotated locations for NP_001152763.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' exon and thus differs in its 5' UTR and initiates translation at a downstream in-frame start codon, and it lacks an alternate in-frame exon in the central coding region, compared to variant 3. The encoded isoform (2, also known as MICAL-1b) is shorter at the N-terminus, compared to isoform 3.
    Source sequence(s)
    AB048948, BC009972, BC042144
    Consensus CDS
    CCDS55047.1
    UniProtKB/Swiss-Prot
    Q8TDZ2
    Related
    ENSP00000351385.3, ENST00000358577.7
    Conserved Domains (5) summary
    cd09358
    Location:611664
    LIM_Mical_like; The LIM domain of Mical (molecule interacting with CasL) like family
    pfam00307
    Location:425521
    CH; Calponin homology (CH) domain
    pfam12130
    Location:841974
    DUF3585; Protein of unknown function (DUF3585)
    pfam13450
    Location:89116
    NAD_binding_8; NAD(P)-binding Rossmann-like domain
    pfam16602
    Location:527607
    USP19_linker; Linker region of USP19 deubiquitinase
  2. NM_001286613.1NP_001273542.1  [F-actin]-monooxygenase MICAL1 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) represents the longest transrcript and encodes the longest isoform (3).
    Source sequence(s)
    AK296284, AL109947, BC042144
    Consensus CDS
    CCDS69170.1
    UniProtKB/Swiss-Prot
    Q8TDZ2
    Related
    ENSP00000486901.1, ENST00000630715.2
    Conserved Domains (5) summary
    cd09358
    Location:716769
    LIM_Mical_like; The LIM domain of Mical (molecule interacting with CasL) like family
    pfam00307
    Location:530626
    CH; Calponin homology (CH) domain
    pfam12130
    Location:9461079
    DUF3585; Protein of unknown function (DUF3585)
    pfam13450
    Location:108135
    NAD_binding_8; NAD(P)-binding Rossmann-like domain
    pfam16602
    Location:632712
    USP19_linker; Linker region of USP19 deubiquitinase
  3. NM_022765.4NP_073602.3  [F-actin]-monooxygenase MICAL1 isoform 1

    See identical proteins and their annotated locations for NP_073602.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) contains an alternate 5' exon and thus differs in its 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 3. The encoded isoform (1, also known as MICAL-1a) is shorter at the N-terminus, compared to isoform 3.
    Source sequence(s)
    BC042144
    Consensus CDS
    CCDS5076.1
    UniProtKB/Swiss-Prot
    Q8TDZ2
    Related
    ENSP00000351664.3, ENST00000358807.7
    Conserved Domains (5) summary
    cd09358
    Location:697750
    LIM_Mical_like; The LIM domain of Mical (molecule interacting with CasL) like family
    pfam00307
    Location:511607
    CH; Calponin homology (CH) domain
    pfam12130
    Location:9271060
    DUF3585; Protein of unknown function (DUF3585)
    pfam13450
    Location:89116
    NAD_binding_8; NAD(P)-binding Rossmann-like domain
    pfam16602
    Location:613693
    USP19_linker; Linker region of USP19 deubiquitinase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p12 Primary Assembly

    Range
    109444062..109465968 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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